2019 ICD-10-CM Diagnosis Code E85

Amyloidosis

    2016 2017 2018 2019 Non-Billable/Non-Specific Code
  • E85 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2019 edition of ICD-10-CM E85 became effective on October 1, 2018.
  • This is the American ICD-10-CM version of E85 - other international versions of ICD-10 E85 may differ.
Type 2 Excludes
Type 2 Excludes Help
A type 2 excludes note represents "not included here". A type 2 excludes note indicates that the condition excluded is not part of the condition it is excluded from but a patient may have both conditions at the same time. When a type 2 excludes note appears under a code it is acceptable to use both the code (E85) and the excluded code together.
  • Alzheimer's disease (
    ICD-10-CM Diagnosis Code G30.0

    Alzheimer's disease with early onset

      2016 2017 2018 2019 Billable/Specific Code
    G30.0-
    )
The following code(s) above E85 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to E85:
  • E00-E89
    2019 ICD-10-CM Range E00-E89

    Endocrine, nutritional and metabolic diseases

    Note
    • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Type 1 Excludes
    • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    Endocrine, nutritional and metabolic diseases
  • E70-E88
    2019 ICD-10-CM Range E70-E88

    Metabolic disorders

    Type 1 Excludes
    • androgen insensitivity syndrome (E34.5-)
    • congenital adrenal hyperplasia (E25.0)
    • Ehlers-Danlos syndrome (Q79.6)
    • hemolytic anemias attributable to enzyme disorders (D55.-)
    • Marfan's syndrome (Q87.4)
    • 5-alpha-reductase deficiency (E29.1)
    Metabolic disorders
Clinical Information
  • A disorder characterized by the localized or diffuse accumulation of amyloid protein in various anatomic sites. It may be primary, due to clonal plasma cell proliferations; secondary, due to long standing infections, chronic inflammatory disorders, or malignancies; or familial. It may affect the nerves, skin, tongue, joints, heart, liver, spleen, kidneys and adrenal glands.
  • A group of diseases in which protein builds up in certain organs (localized amyloidosis) or throughout the body (systemic amyloidosis). Amyloidosis may be either primary (with no known cause), secondary (caused by another disease, including some types of cancer, such as multiple myeloma), or hereditary (passed down from parents to children). Many organs are affected by amyloidosis. The organs affected may depend on whether the amyloidosis is the primary, secondary, or hereditary form.
  • A group of diseases in which protein is deposited in specific organs (localized amyloidosis) or throughout the body (systemic amyloidosis). Amyloidosis may be either primary (plasma cell neoplasm) or secondary (caused by a long standing infection or another disease or some types of cancer). Generally, primary amyloidosis affects the nerves, skin, tongue, joints, heart, and liver; secondary amyloidosis often affects the spleen, kidneys, liver, and adrenal glands.
  • A group of diseases in which protein is deposited in specific organs or throughout the body.
  • A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of amyloid. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.
  • Amyloidosis occurs when abnormal proteins build up and form deposits. The deposits can collect in organs such as the kidney and heart. This can cause the organs to become stiff and unable to work the way they should. There are three main types of amyloidosis:
    • primary - with no known cause
    • secondary - caused by another disease, including some types of cancer
    • familial - passed down through genes
    treatment depends on the type of amyloidosis you have.
  • Any disease manifested by the pathogenic accumulation of amyloid in organs and tissues.
Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
Code annotations containing back-references to E85:
  • Code First: N08
    , N29
    , I79.8
    , J99
    , K77
    , D77
    , L99
    , M14.8
    , G32.8
    , G63
    , G99.0
    , G99.8
    , H42
    , I43
    , I68.0
    ICD-10-CM Diagnosis Code N08

    Glomerular disorders in diseases classified elsewhere

      2016 2017 2018 2019 Billable/Specific Code Manifestation Code
    Applicable To
    • Glomerulonephritis
    • Nephritis
    • Nephropathy
    Code First
    Type 1 Excludes
    • glomerulonephritis, nephritis and nephropathy (in):
    • antiglomerular basement membrane disease (M31.0)
    • diabetes (E08-E13 with .21)
    • gonococcal (A54.21)
    • Goodpasture's syndrome (M31.0)
    • hemolytic-uremic syndrome (D59.3)
    • lupus (M32.14)
    • mumps (B26.83)
    • syphilis (A52.75)
    • systemic lupus erythematosus (M32.14)
    • Wegener's granulomatosis (M31.31)
    • pyelonephritis in diseases classified elsewhere (N16)
    • renal tubulo-interstitial disorders classified elsewhere (N16)
    ICD-10-CM Diagnosis Code N29

    Other disorders of kidney and ureter in diseases classified elsewhere

      2016 2017 2018 2019 Billable/Specific Code Manifestation Code
    Code First
    Type 1 Excludes
    ICD-10-CM Diagnosis Code I79.8

    Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere

      2016 2017 2018 2019 Billable/Specific Code Manifestation Code
    Code First
    • underlying disease, such as:
    • amyloidosis (E85.-)
    Type 1 Excludes
    • diabetic (peripheral) angiopathy (E08-E13 with .51-.52)
    • syphilitic endarteritis (A52.09)
    • tuberculous endarteritis (A18.89)
    ICD-10-CM Diagnosis Code J99

    Respiratory disorders in diseases classified elsewhere

      2016 2017 2018 2019 Billable/Specific Code Manifestation Code
    Code First
    • underlying disease, such as:
    • amyloidosis (E85.-)
    • ankylosing spondylitis (M45)
    • congenital syphilis (A50.5)
    • cryoglobulinemia (D89.1)
    • early congenital syphilis (A50.0)
    • plasminogen deficiency (E88.02)
    • schistosomiasis (B65.0-B65.9)
    Type 1 Excludes
    ICD-10-CM Diagnosis Code K77

    Liver disorders in diseases classified elsewhere

      2016 2017 2018 2019 Billable/Specific Code Manifestation Code
    Code First
    Type 1 Excludes
    • alcoholic hepatitis (K70.1-)
    • alcoholic liver disease (K70.-)
    • cytomegaloviral hepatitis (B25.1)
    • herpesviral [herpes simplex] hepatitis (B00.81)
    • infectious mononucleosis with liver disease (B27.0-B27.9 with .9)
    • mumps hepatitis (B26.81)
    • sarcoidosis with liver disease (D86.89)
    • secondary syphilis with liver disease (A51.45)
    • syphilis (late) with liver disease (A52.74)
    • toxoplasmosis (acquired) hepatitis (B58.1)
    • tuberculosis with liver disease (A18.83)
    ICD-10-CM Diagnosis Code D77

    Other disorders of blood and blood-forming organs in diseases classified elsewhere

      2016 2017 2018 2019 Billable/Specific Code Manifestation Code
    Code First
    Type 1 Excludes
    • rupture of spleen due to Plasmodium vivax malaria (B51.0)
    • splenitis, splenomegaly in late syphilis (A52.79)
    • splenitis, splenomegaly in tuberculosis (A18.85)
    ICD-10-CM Diagnosis Code L99

    Other disorders of skin and subcutaneous tissue in diseases classified elsewhere

      2016 2017 2018 2019 Billable/Specific Code Manifestation Code
    Code First
    • underlying disease, such as:
    • amyloidosis (E85.-)
    Type 1 Excludes
    ICD-10-CM Diagnosis Code M14.8

    Arthropathies in other specified diseases classified elsewhere

      2016 2017 2018 2019 Non-Billable/Non-Specific Code
    Code First
    • underlying disease, such as:
    • amyloidosis (E85.-)
    • erythema multiforme (L51.-)
    • erythema nodosum (L52)
    • hemochromatosis (E83.11-)
    • hyperparathyroidism (E21.-)
    • hypothyroidism (E00-E03)
    • sickle-cell disorders (D57.-)
    • thyrotoxicosis [hyperthyroidism] (E05.-)
    • Whipple's disease (K90.81)
    ICD-10-CM Diagnosis Code G32.8

    Other specified degenerative disorders of nervous system in diseases classified elsewhere

      2016 2017 2018 2019 Non-Billable/Non-Specific Code
    Code First
    • underlying disease, such as:
    • amyloidosis cerebral degeneration (E85.-)
    • cerebral degeneration (due to) hypothyroidism (E00.0-E03.9)
    • cerebral degeneration (due to) neoplasm (C00-D49)
    • cerebral degeneration (due to) vitamin B deficiency, except thiamine (E52-E53.-)
    Type 1 Excludes
    • superior hemorrhagic polioencephalitis [Wernicke's encephalopathy] (E51.2)
    ICD-10-CM Diagnosis Code G63

    Polyneuropathy in diseases classified elsewhere

      2016 2017 2018 2019 Billable/Specific Code Manifestation Code
    Code First
    Type 1 Excludes
    ICD-10-CM Diagnosis Code G99.0

    Autonomic neuropathy in diseases classified elsewhere

      2016 2017 2018 2019 Billable/Specific Code Manifestation Code
    Code First
    Type 1 Excludes
    • diabetic autonomic neuropathy (E08-E13 with .43)
    ICD-10-CM Diagnosis Code G99.8

    Other specified disorders of nervous system in diseases classified elsewhere

      2016 2017 2018 2019 Billable/Specific Code Manifestation Code
    Code First
    • underlying disorder, such as:
    • amyloidosis (E85.-)
    • avitaminosis (E56.9)
    Type 1 Excludes
    ICD-10-CM Diagnosis Code H42

    Glaucoma in diseases classified elsewhere

      2016 2017 2018 2019 Billable/Specific Code Manifestation Code
    Code First
    Type 1 Excludes
    • glaucoma (in) onchocerciasis (B73.02)
    • glaucoma (in) syphilis (A52.71)
    • glaucoma (in) tuberculous (A18.59)
    ICD-10-CM Diagnosis Code I43

    Cardiomyopathy in diseases classified elsewhere

      2016 2017 2018 2019 Billable/Specific Code Manifestation Code
    Code First
    Type 1 Excludes
    ICD-10-CM Diagnosis Code I68.0

    Cerebral amyloid angiopathy

      2016 2017 2018 2019 Billable/Specific Code Manifestation Code
    Code First
    • underlying amyloidosis (E85.-)
  • Type 1 Excludes: E27.1
    ICD-10-CM Diagnosis Code E27.1

    Primary adrenocortical insufficiency

      2016 2017 2018 2019 Billable/Specific Code
    Applicable To
    • Addison's disease
    • Autoimmune adrenalitis
    Type 1 Excludes
    • Addison only phenotype adrenoleukodystrophy (E71.528)
    • amyloidosis (E85.-)
    • tuberculous Addison's disease (A18.7)
    • Waterhouse-Friderichsen syndrome (A39.1)
  • Type 2 Excludes: N07
    , N07
    , K76
    ICD-10-CM Diagnosis Code N07

    Hereditary nephropathy, not elsewhere classified

      2016 2017 2018 2019 Non-Billable/Non-Specific Code
    Type 2 Excludes
    • Alport's syndrome (Q87.81-)
    • hereditary amyloid nephropathy (E85.-)
    • nail patella syndrome (Q87.2)
    • non-neuropathic heredofamilial amyloidosis (E85.-)
    ICD-10-CM Diagnosis Code N07

    Hereditary nephropathy, not elsewhere classified

      2016 2017 2018 2019 Non-Billable/Non-Specific Code
    Type 2 Excludes
    • Alport's syndrome (Q87.81-)
    • hereditary amyloid nephropathy (E85.-)
    • nail patella syndrome (Q87.2)
    • non-neuropathic heredofamilial amyloidosis (E85.-)
    ICD-10-CM Diagnosis Code K76

    Other diseases of liver

      2016 2017 2018 2019 Non-Billable/Non-Specific Code
    Type 2 Excludes
    • alcoholic liver disease (K70.-)
    • amyloid degeneration of liver (E85.-)
    • cystic disease of liver (congenital) (Q44.6)
    • hepatic vein thrombosis (I82.0)
    • hepatomegaly NOS (R16.0)
    • pigmentary cirrhosis (of liver) (E83.110)
    • portal vein thrombosis (I81)
    • toxic liver disease (K71.-)
ICD-10-CM Codes Adjacent To E85
E83.81 Hungry bone syndrome
E83.89 Other disorders of mineral metabolism
E83.9 Disorder of mineral metabolism, unspecified
E84 Cystic fibrosis
E84.0 Cystic fibrosis with pulmonary manifestations
E84.1 Cystic fibrosis with intestinal manifestations
E84.11 Meconium ileus in cystic fibrosis
E84.19 Cystic fibrosis with other intestinal manifestations
E84.8 Cystic fibrosis with other manifestations
E84.9 Cystic fibrosis, unspecified
E85 Amyloidosis
E85.0 Non-neuropathic heredofamilial amyloidosis
E85.1 Neuropathic heredofamilial amyloidosis
E85.2 Heredofamilial amyloidosis, unspecified
E85.3 Secondary systemic amyloidosis
E85.4 Organ-limited amyloidosis
E85.8 Other amyloidosis
E85.81 Light chain (AL) amyloidosis
E85.82 Wild-type transthyretin-related (ATTR) amyloidosis
E85.89 Other amyloidosis
E85.9 Amyloidosis, unspecified

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.