2021 ICD-10-CM Diagnosis Code E85.0

Non-neuropathic heredofamilial amyloidosis

    2016 2017 2018 2019 2020 2021 Billable/Specific Code
  • E85.0 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2021 edition of ICD-10-CM E85.0 became effective on October 1, 2020.
  • This is the American ICD-10-CM version of E85.0 - other international versions of ICD-10 E85.0 may differ.
Applicable To
  • Hereditary amyloid nephropathy
Code Also
Code Also Help
A code also note instructs that 2 codes may be required to fully describe a condition but the sequencing of the two codes is discretionary, depending on the severity of the conditions and the reason for the encounter.
  • associated disorders, such as:
  • autoinflammatory syndromes (
    ICD-10-CM Diagnosis Code M04
    • M04 Autoinflammatory syndromes
      • M04.1 Periodic fever syndromes
      • M04.2 Cryopyrin-associated periodic syndromes
      • M04.8 Other autoinflammatory syndromes
      • M04.9 Autoinflammatory syndrome, unspecified
    M04.-
    )
Type 2 Excludes
Type 2 Excludes Help
A type 2 excludes note represents "not included here". A type 2 excludes note indicates that the condition excluded is not part of the condition it is excluded from but a patient may have both conditions at the same time. When a type 2 excludes note appears under a code it is acceptable to use both the code (E85.0) and the excluded code together.
  • Transthyretin-related (ATTR) familial amyloid cardiomyopathy (
    ICD-10-CM Diagnosis Code E85.4

    Organ-limited amyloidosis

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Localized amyloidosis
    • Transthyretin-related (ATTR) familial amyloid cardiomyopathy
    E85.4
    )
The following code(s) above E85.0 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to E85.0:
  • E00-E89
    2021 ICD-10-CM Range E00-E89

    Endocrine, nutritional and metabolic diseases

    Note
    • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Type 1 Excludes
    • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    Endocrine, nutritional and metabolic diseases
  • E70-E88
    2021 ICD-10-CM Range E70-E88

    Metabolic disorders

    Type 1 Excludes
    • androgen insensitivity syndrome (E34.5-)
    • congenital adrenal hyperplasia (E25.0)
    • Ehlers-Danlos syndromes (Q79.6-)
    • hemolytic anemias attributable to enzyme disorders (D55.-)
    • Marfan's syndrome (Q87.4)
    • 5-alpha-reductase deficiency (E29.1)
    Metabolic disorders
  • E85
    ICD-10-CM Diagnosis Code E85

    Amyloidosis

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 2 Excludes
    Amyloidosis
Approximate Synonyms
  • Familial mediterranean fever
  • Familial non-neuropathic amyloidosis
  • Nonneuropathic heredofamilial amyloidosis
Clinical Information
  • A group of hereditary autoinflammation diseases, characterized by recurrent fever, abdominal pain, headache, rash, pleurisy; and arthritis. Orchitis; benign meningitis; and amyloidosis may also occur. Homozygous or compound heterozygous mutations in marenostrin gene result in autosomal recessive transmission; simple heterozygous, autosomal dominant form of the disease.
  • A usually autosomal recessive inherited inflammatory disorder caused by mutations in the mefv gene. It is characterized by recurrent painful inflammatory attacks in the abdomen, joints, and chest. The inflammatory attacks are associated with fever.
ICD-10-CM E85.0 is grouped within Diagnostic Related Group(s) (MS-DRG v38.0):
  • 545 Connective tissue disorders with mcc
  • 546 Connective tissue disorders with cc
  • 547 Connective tissue disorders without cc/mcc

Convert E85.0 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
Code annotations containing back-references to E85.0:
  • Type 1 Excludes: K65
    , K65
    ICD-10-CM Diagnosis Code K65

    Peritonitis

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Code Also
    • if applicable diverticular disease of intestine (K57.-)
    Type 1 Excludes
    • acute appendicitis with generalized peritonitis (K35.2-)
    • aseptic peritonitis (T81.6)
    • benign paroxysmal peritonitis (E85.0)
    • chemical peritonitis (T81.6)
    • gonococcal peritonitis (A54.85)
    • neonatal peritonitis (P78.0-P78.1)
    • pelvic peritonitis, female (N73.3-N73.5)
    • periodic familial peritonitis (E85.0)
    • peritonitis due to talc or other foreign substance (T81.6)
    • peritonitis in chlamydia (A74.81)
    • peritonitis in diphtheria (A36.89)
    • peritonitis in syphilis (late) (A52.74)
    • peritonitis in tuberculosis (A18.31)
    • peritonitis with or following abortion or ectopic or molar pregnancy (O00-O07, O08.0)
    • peritonitis with or following appendicitis (K35.-)
    • puerperal peritonitis (O85)
    • retroperitoneal infections (K68.-)
    Use Additional
    • code (B95-B97), to identify infectious agent, if known
    ICD-10-CM Diagnosis Code K65

    Peritonitis

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Code Also
    • if applicable diverticular disease of intestine (K57.-)
    Type 1 Excludes
    • acute appendicitis with generalized peritonitis (K35.2-)
    • aseptic peritonitis (T81.6)
    • benign paroxysmal peritonitis (E85.0)
    • chemical peritonitis (T81.6)
    • gonococcal peritonitis (A54.85)
    • neonatal peritonitis (P78.0-P78.1)
    • pelvic peritonitis, female (N73.3-N73.5)
    • periodic familial peritonitis (E85.0)
    • peritonitis due to talc or other foreign substance (T81.6)
    • peritonitis in chlamydia (A74.81)
    • peritonitis in diphtheria (A36.89)
    • peritonitis in syphilis (late) (A52.74)
    • peritonitis in tuberculosis (A18.31)
    • peritonitis with or following abortion or ectopic or molar pregnancy (O00-O07, O08.0)
    • peritonitis with or following appendicitis (K35.-)
    • puerperal peritonitis (O85)
    • retroperitoneal infections (K68.-)
    Use Additional
    • code (B95-B97), to identify infectious agent, if known

Diagnosis Index entries containing back-references to E85.0:
  • Amyloidosis (generalized) (primary) E85.9
    ICD-10-CM Diagnosis Code E85.9

    Amyloidosis, unspecified

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    • non-neuropathic heredofamilial E85.0
  • Myopathy G72.9
    ICD-10-CM Diagnosis Code G72.9

    Myopathy, unspecified

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    • in (due to)
      • amyloidosis E85.0
  • Nephropathy N28.9
    - see also Nephritis
    ICD-10-CM Diagnosis Code N28.9

    Disorder of kidney and ureter, unspecified

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Nephropathy NOS
    • Renal disease (acute) NOS
    • Renal insufficiency (acute)
    Type 1 Excludes
    • chronic renal insufficiency (N18.9)
    • unspecified nephritic syndrome (N05.-)
    • amyloid, hereditary E85.0
  • Peritonitis (adhesive) (bacterial) (fibrinous) (hemorrhagic) (idiopathic) (localized) (perforative) (primary) (with adhesions) (with effusion) K65.9
    ICD-10-CM Diagnosis Code K65.9

    Peritonitis, unspecified

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Bacterial peritonitis NOS
  • Polyserositis
    • periodic, familial E85.0

ICD-10-CM Codes Adjacent To E85.0
E83.89 Other disorders of mineral metabolism
E83.9 Disorder of mineral metabolism, unspecified
E84 Cystic fibrosis
E84.0 Cystic fibrosis with pulmonary manifestations
E84.1 Cystic fibrosis with intestinal manifestations
E84.11 Meconium ileus in cystic fibrosis
E84.19 Cystic fibrosis with other intestinal manifestations
E84.8 Cystic fibrosis with other manifestations
E84.9 Cystic fibrosis, unspecified
E85 Amyloidosis
E85.0 Non-neuropathic heredofamilial amyloidosis
E85.1 Neuropathic heredofamilial amyloidosis
E85.2 Heredofamilial amyloidosis, unspecified
E85.3 Secondary systemic amyloidosis
E85.4 Organ-limited amyloidosis
E85.8 Other amyloidosis
E85.81 Light chain (AL) amyloidosis
E85.82 Wild-type transthyretin-related (ATTR) amyloidosis
E85.89 Other amyloidosis
E85.9 Amyloidosis, unspecified
E86 Volume depletion

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.