ICD-10-CM Codes
E00-E89
E70-E88
E85-
2023 ICD-10-CM Diagnosis Code E85.4

2023 ICD-10-CM Diagnosis Code E85.4

Organ-limited amyloidosis

2016

2017

2018

2019

2020

2021

2022

2023

Billable/Specific Code

E85.4 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
The 2023 edition of ICD-10-CM E85.4 became effective on October 1, 2022.
This is the American ICD-10-CM version of E85.4 - other international versions of ICD-10 E85.4 may differ.

Applicable To

Localized amyloidosis
Transthyretin-related (ATTR) familial amyloid cardiomyopathy

The following code(s) above E85.4 contain annotation back-references

Annotation Back-References

In this context, annotation back-references refer to codes that contain:

Applicable To annotations, or
Code Also annotations, or
Code First annotations, or
Excludes1 annotations, or
Excludes2 annotations, or
Includes annotations, or
Note annotations, or
Use Additional annotations

that may be applicable to E85.4:

E00-E89
2023 ICD-10-CM Range E00-E89
Endocrine, nutritional and metabolic diseases
Note
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Type 1 Excludes
- transitory endocrine and metabolic disorders specific to newborn (P70-P74)
Endocrine, nutritional and metabolic diseases
E70-E88
2023 ICD-10-CM Range E70-E88
Metabolic disorders
Type 1 Excludes
- androgen insensitivity syndrome (E34.5-)
- congenital adrenal hyperplasia (E25.0)
- hemolytic anemias attributable to enzyme disorders (D55.-)
- Marfan's syndrome (Q87.4)
- 5-alpha-reductase deficiency (E29.1)
Type 2 Excludes
- Ehlers-Danlos syndromes (Q79.6-)
Metabolic disorders
E85
ICD-10-CM Diagnosis Code E85
Amyloidosis
Type 2 Excludes
- Alzheimer's disease (G30.0-)
Amyloidosis

Approximate Synonyms

Cardiac amyloidosis
Cerebral amyloid angiopathy
Cutaneous amyloidosis
Lichen amyloidosis
Organ limited amyloidosis
Senile cardiac amyloidosis

ICD-10-CM E85.4 is grouped within Diagnostic Related Group(s) (MS-DRG v40.0):

545 Connective tissue disorders with mcc
546 Connective tissue disorders with cc
547 Connective tissue disorders without cc/mcc

Convert E85.4 to ICD-9-CM

Code History

2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
2017 (effective 10/1/2016): No change
2018 (effective 10/1/2017): No change
2019 (effective 10/1/2018): No change
2020 (effective 10/1/2019): No change
2021 (effective 10/1/2020): No change
2022 (effective 10/1/2021): No change
2023 (effective 10/1/2022): No change

Code annotations containing back-references to E85.4:

Type 2 Excludes: E85.0

ICD-10-CM Diagnosis Code E85.0
Non-neuropathic heredofamilial amyloidosis
Applicable To
- Hereditary amyloid nephropathy
Code Also
- associated disorders, such as:
- autoinflammatory syndromes (M04.-)
Type 2 Excludes
- Transthyretin-related (ATTR) familial amyloid cardiomyopathy (E85.4)

Diagnosis Index entries containing back-references to E85.4:

Amyloid heart E85.4 (disease)
Amyloidosis (generalized) (primary) E85.9
ICD-10-CM Diagnosis Code E85.9
Amyloidosis, unspecified
- with lung involvement E85.4
- heart E85.4
- liver E85.4
- localized E85.4
- organ limited E85.4
- pulmonary E85.4
- skin E85.4 (lichen) (macular)
- subglottic E85.4
Angiopathia, angiopathy I99.9
ICD-10-CM Diagnosis Code I99.9
Unspecified disorder of circulatory system
- cerebral I67.9
  ICD-10-CM Diagnosis Code I67.9
  Cerebrovascular disease, unspecified
  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  - amyloid E85.4
Arthritis, arthritic (acute) (chronic) (nonpyogenic) (subacute) M19.90
ICD-10-CM Diagnosis Code M19.90
Unspecified osteoarthritis, unspecified site
Applicable To
Arthrosis NOS
Arthritis NOS
Osteoarthritis NOS
- in (due to)
  - amyloidosis E85.4 - see also subcategory M14.8-
Arthropathy M12.9
- see also Arthritis
ICD-10-CM Diagnosis Code M12.9
Arthropathy, unspecified
- in (due to)
  - amyloidosis E85.4
Cardiomyopathy (familial) (idiopathic) I42.9
ICD-10-CM Diagnosis Code I42.9
Cardiomyopathy, unspecified
Applicable To
Cardiomyopathy (primary) (secondary) NOS
- amyloid E85.4
  - transthyretin-related E85.4 (ATTR)
- transthyretin-related E85.4 (ATTR)
Degeneration, degenerative
- artery, arterial (atheromatous) (calcareous) - see also Arteriosclerosis
  - cerebral, amyloid E85.4
- cutis L98.8
  ICD-10-CM Diagnosis Code L98.8
  Other specified disorders of the skin and subcutaneous tissue
  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  - amyloid E85.4
- heart - see also Degeneration, myocardial
  - amyloid E85.4
- kidney N28.89
  ICD-10-CM Diagnosis Code N28.89
  Other specified disorders of kidney and ureter
  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  - amyloid E85.4
- liver (diffuse) K76.89
  ICD-10-CM Diagnosis Code K76.89
  Other specified diseases of liver
  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  Applicable To
  Cyst (simple) of liver
  Focal nodular hyperplasia of liver
  Hepatoptosis
  - amyloid E85.4
- nervous system G31.9
  ICD-10-CM Diagnosis Code G31.9
  Degenerative disease of nervous system, unspecified
  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  - amyloid E85.4
- skin L98.8
  ICD-10-CM Diagnosis Code L98.8
  Other specified disorders of the skin and subcutaneous tissue
  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  - amyloid E85.4
- spinal (cord) G31.89
  ICD-10-CM Diagnosis Code G31.89
  Other specified degenerative diseases of nervous system
  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  - amyloid E85.4
- spleen D73.0
  ICD-10-CM Diagnosis Code D73.0
  Hyposplenism
  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  Applicable To
  Atrophy of spleen
  Type 1 Excludes
  asplenia (congenital) (Q89.01)
  postsurgical absence of spleen (Z90.81)
  - amyloid E85.4
- intestine, amyloid E85.4
Disease, diseased - see also Syndrome
- gastrointestinal (tract) K92.9
  ICD-10-CM Diagnosis Code K92.9
  Disease of digestive system, unspecified
  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  - amyloid E85.4
- heart (organic) I51.9
  ICD-10-CM Diagnosis Code I51.9
  Heart disease, unspecified
  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  - amyloid E85.4
- lung J98.4
  ICD-10-CM Diagnosis Code J98.4
  Other disorders of lung
  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  Applicable To
  Calcification of lung
  Cystic lung disease (acquired)
  Lung disease NOS
  Pulmolithiasis
  Type 1 Excludes
  acute interstitial pneumonitis (J84.114)
  pulmonary insufficiency following surgery (J95.1-J95.2)
  - in
    - amyloidosis E85.4
- spleen D73.9
  ICD-10-CM Diagnosis Code D73.9
  Disease of spleen, unspecified
  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  - amyloid E85.4
Disorder (of) - see also Disease
- glomerular (in) N05.9
  ICD-10-CM Diagnosis Code N05.9
  Unspecified nephritic syndrome with unspecified morphologic changes
  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  - amyloidosis E85.4
Glaucoma H40.9
ICD-10-CM Diagnosis Code H40.9
Unspecified glaucoma
- in (due to)
  - amyloidosis E85.4
Glomerulonephritis N05.9
- see also Nephritis
ICD-10-CM Diagnosis Code N05.9
Unspecified nephritic syndrome with unspecified morphologic changes
- in (due to)
  - amyloidosis E85.4
Lichen L28.0
ICD-10-CM Diagnosis Code L28.0
Lichen simplex chronicus
Applicable To
Circumscribed neurodermatitis
Lichen NOS
- amyloidosis E85.4
Nephritis, nephritic (albuminuric) (azotemic) (congenital) (disseminated) (epithelial) (familial) (focal) (granulomatous) (hemorrhagic) (infantile) (nonsuppurative, excretory) (uremic) N05.9
ICD-10-CM Diagnosis Code N05.9
Unspecified nephritic syndrome with unspecified morphologic changes
- amyloid E85.4
Nephrosis, nephrotic (Epstein's) (syndrome) (congenital) N04.9
ICD-10-CM Diagnosis Code N04.9
Nephrotic syndrome with unspecified morphologic changes
- in
  - amyloidosis E85.4
Neuritis (rheumatoid) M79.2
ICD-10-CM Diagnosis Code M79.2
Neuralgia and neuritis, unspecified
Type 1 Excludes
brachial radiculitis NOS (M54.1)
lumbosacral radiculitis NOS (M54.1)
mononeuropathies (G56-G58)
radiculitis NOS (M54.1)
sciatica (M54.3-M54.4)
- amyloid, any site E85.4
Neuropathy, neuropathic G62.9
ICD-10-CM Diagnosis Code G62.9
Polyneuropathy, unspecified
Applicable To
Neuropathy NOS
- peripheral (nerve) G62.9
  - see also Polyneuropathy
  ICD-10-CM Diagnosis Code G62.9
  Polyneuropathy, unspecified
  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  Applicable To
  Neuropathy NOS
  - autonomic G90.9
    ICD-10-CM Diagnosis Code G90.9
    Disorder of the autonomic nervous system, unspecified
    2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
    - in (due to)
      - amyloidosis E85.4

ICD-10-CM Codes Adjacent To E85.4

E84.1 Cystic fibrosis with intestinal manifestations

E84.11 Meconium ileus in cystic fibrosis

E84.19 Cystic fibrosis with other intestinal manifestations

E84.8 Cystic fibrosis with other manifestations

E84.9 Cystic fibrosis, unspecified

E85 Amyloidosis

E85.0 Non-neuropathic heredofamilial amyloidosis

E85.1 Neuropathic heredofamilial amyloidosis

E85.2 Heredofamilial amyloidosis, unspecified

E85.3 Secondary systemic amyloidosis

E85.4 Organ-limited amyloidosis

E85.8 Other amyloidosis

E85.81 Light chain (AL) amyloidosis

E85.82 Wild-type transthyretin-related (ATTR) amyloidosis

E85.89 Other amyloidosis

E85.9 Amyloidosis, unspecified

E86 Volume depletion

E86.0 Dehydration

E86.1 Hypovolemia

E86.9 Volume depletion, unspecified

E87 Other disorders of fluid, electrolyte and acid-base balance

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

2023 ICD-10-CM Diagnosis Code E85.4

Organ-limited amyloidosis

Endocrine, nutritional and metabolic diseases

Metabolic disorders

Amyloidosis

Non-neuropathic heredofamilial amyloidosis

Amyloidosis, unspecified

Unspecified disorder of circulatory system

Cerebrovascular disease, unspecified

Unspecified osteoarthritis, unspecified site

Arthropathy, unspecified

Cardiomyopathy, unspecified

Other specified disorders of the skin and subcutaneous tissue

Other specified disorders of kidney and ureter

Other specified diseases of liver

Degenerative disease of nervous system, unspecified

Other specified disorders of the skin and subcutaneous tissue

Other specified degenerative diseases of nervous system

Hyposplenism

Disease of digestive system, unspecified

Heart disease, unspecified

Other disorders of lung

Disease of spleen, unspecified

Unspecified nephritic syndrome with unspecified morphologic changes

Unspecified glaucoma

Unspecified nephritic syndrome with unspecified morphologic changes

Lichen simplex chronicus

Unspecified nephritic syndrome with unspecified morphologic changes

Nephrotic syndrome with unspecified morphologic changes

Neuralgia and neuritis, unspecified

Polyneuropathy, unspecified

Polyneuropathy, unspecified

Disorder of the autonomic nervous system, unspecified