2019 ICD-10-CM Diagnosis Code E85.4

Organ-limited amyloidosis

    2016 2017 2018 2019 Billable/Specific Code
  • E85.4 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2019 edition of ICD-10-CM E85.4 became effective on October 1, 2018.
  • This is the American ICD-10-CM version of E85.4 - other international versions of ICD-10 E85.4 may differ.
Applicable To
  • Localized amyloidosis
  • Transthyretin-related (ATTR) familial amyloid cardiomyopathy
The following code(s) above E85.4 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to E85.4:
  • E00-E89
    2019 ICD-10-CM Range E00-E89

    Endocrine, nutritional and metabolic diseases

    Note
    • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Type 1 Excludes
    • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    Endocrine, nutritional and metabolic diseases
  • E70-E88
    2019 ICD-10-CM Range E70-E88

    Metabolic disorders

    Type 1 Excludes
    • androgen insensitivity syndrome (E34.5-)
    • congenital adrenal hyperplasia (E25.0)
    • Ehlers-Danlos syndrome (Q79.6)
    • hemolytic anemias attributable to enzyme disorders (D55.-)
    • Marfan's syndrome (Q87.4)
    • 5-alpha-reductase deficiency (E29.1)
    Metabolic disorders
  • E85
    ICD-10-CM Diagnosis Code E85

    Amyloidosis

      2016 2017 2018 2019 Non-Billable/Non-Specific Code
    Type 2 Excludes
    Amyloidosis
Approximate Synonyms
  • Cardiac amyloidosis
  • Cerebral amyloid angiopathy
  • Cutaneous amyloidosis
  • Lichen amyloidosis
  • Organ limited amyloidosis
  • Senile cardiac amyloidosis
ICD-10-CM E85.4 is grouped within Diagnostic Related Group(s) (MS-DRG v36.0):
  • 545 Connective tissue disorders with mcc
  • 546 Connective tissue disorders with cc
  • 547 Connective tissue disorders without cc/mcc

Convert E85.4 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
Code annotations containing back-references to E85.4:
  • Type 2 Excludes: E85.0
    ICD-10-CM Diagnosis Code E85.0

    Non-neuropathic heredofamilial amyloidosis

      2016 2017 2018 2019 Billable/Specific Code
    Applicable To
    • Hereditary amyloid nephropathy
    Code Also
    • associated disorders, such as:
    • autoinflammatory syndromes (M04.-)
    Type 2 Excludes
    • Transthyretin-related (ATTR) familial amyloid cardiomyopathy (E85.4)

Diagnosis Index entries containing back-references to E85.4:
  • Amyloid heart E85.4 (disease)
  • Amyloidosis (generalized) (primary) E85.9
    ICD-10-CM Diagnosis Code E85.9

    Amyloidosis, unspecified

      2016 2017 2018 2019 Billable/Specific Code
    • with lung involvement E85.4
    • heart E85.4
    • liver E85.4
    • localized E85.4
    • organ limited E85.4
    • pulmonary E85.4
    • skin E85.4 (lichen) (macular)
    • subglottic E85.4
  • Angiopathia, angiopathy I99.9
    ICD-10-CM Diagnosis Code I99.9

    Unspecified disorder of circulatory system

      2016 2017 2018 2019 Billable/Specific Code
    • cerebral I67.9
      ICD-10-CM Diagnosis Code I67.9

      Cerebrovascular disease, unspecified

        2016 2017 2018 2019 Billable/Specific Code
      • amyloid E85.4
  • Arthritis, arthritic (acute) (chronic) (nonpyogenic) (subacute) M19.90
    ICD-10-CM Diagnosis Code M19.90

    Unspecified osteoarthritis, unspecified site

      2016 2017 2018 2019 Billable/Specific Code
    Applicable To
    • Arthrosis NOS
    • Arthritis NOS
    • Osteoarthritis NOS
    • in (due to)
      • amyloidosis E85.4 - see also subcategory M14.8-
  • Arthropathy M12.9
    - see also Arthritis
    ICD-10-CM Diagnosis Code M12.9

    Arthropathy, unspecified

      2016 2017 2018 2019 Billable/Specific Code
    • in (due to)
      • amyloidosis E85.4
  • Cardiomyopathy (familial) (idiopathic) I42.9
    ICD-10-CM Diagnosis Code I42.9

    Cardiomyopathy, unspecified

      2016 2017 2018 2019 Billable/Specific Code
    Applicable To
    • Cardiomyopathy (primary) (secondary) NOS
    • amyloid E85.4
      • transthyretin-related E85.4 (ATTR)
    • transthyretin-related E85.4 (ATTR)
  • Degeneration, degenerative
    • artery, arterial (atheromatous) (calcareous) - see also Arteriosclerosis
      • cerebral, amyloid E85.4
    • cutis L98.8
      ICD-10-CM Diagnosis Code L98.8

      Other specified disorders of the skin and subcutaneous tissue

        2016 2017 2018 2019 Billable/Specific Code
      • amyloid E85.4
    • heart - see also Degeneration, myocardial
      • amyloid E85.4
    • kidney N28.89
      ICD-10-CM Diagnosis Code N28.89

      Other specified disorders of kidney and ureter

        2016 2017 2018 2019 Billable/Specific Code
      • amyloid E85.4
    • liver (diffuse) K76.89
      ICD-10-CM Diagnosis Code K76.89

      Other specified diseases of liver

        2016 2017 2018 2019 Billable/Specific Code
      Applicable To
      • Cyst (simple) of liver
      • Focal nodular hyperplasia of liver
      • Hepatoptosis
      • amyloid E85.4
    • nervous system G31.9
      ICD-10-CM Diagnosis Code G31.9

      Degenerative disease of nervous system, unspecified

        2016 2017 2018 2019 Billable/Specific Code
      • amyloid E85.4
    • skin L98.8
      ICD-10-CM Diagnosis Code L98.8

      Other specified disorders of the skin and subcutaneous tissue

        2016 2017 2018 2019 Billable/Specific Code
      • amyloid E85.4
    • spinal (cord) G31.89
      ICD-10-CM Diagnosis Code G31.89

      Other specified degenerative diseases of nervous system

        2016 2017 2018 2019 Billable/Specific Code
      • amyloid E85.4
    • spleen D73.0
      ICD-10-CM Diagnosis Code D73.0

      Hyposplenism

        2016 2017 2018 2019 Billable/Specific Code
      Applicable To
      • Atrophy of spleen
      Type 1 Excludes
      • asplenia (congenital) (Q89.01)
      • postsurgical absence of spleen (Z90.81)
      • amyloid E85.4
    • intestine, amyloid E85.4
  • Disease, diseased - see also Syndrome
    • gastrointestinal (tract) K92.9
      ICD-10-CM Diagnosis Code K92.9

      Disease of digestive system, unspecified

        2016 2017 2018 2019 Billable/Specific Code
      • amyloid E85.4
    • heart (organic) I51.9
      ICD-10-CM Diagnosis Code I51.9

      Heart disease, unspecified

        2016 2017 2018 2019 Billable/Specific Code
      • amyloid E85.4
    • lung J98.4
      ICD-10-CM Diagnosis Code J98.4

      Other disorders of lung

        2016 2017 2018 2019 Billable/Specific Code
      Applicable To
      • Calcification of lung
      • Cystic lung disease (acquired)
      • Lung disease NOS
      • Pulmolithiasis
      Type 1 Excludes
      • acute interstitial pneumonitis (J84.114)
      • pulmonary insufficiency following surgery (J95.1-J95.2)
      • in
        • amyloidosis E85.4
    • spleen D73.9
      ICD-10-CM Diagnosis Code D73.9

      Disease of spleen, unspecified

        2016 2017 2018 2019 Billable/Specific Code
      • amyloid E85.4
  • Disorder (of) - see also Disease
    • glomerular (in) N05.9
      ICD-10-CM Diagnosis Code N05.9

      Unspecified nephritic syndrome with unspecified morphologic changes

        2016 2017 2018 2019 Billable/Specific Code
      • amyloidosis E85.4
  • Glaucoma H40.9
    ICD-10-CM Diagnosis Code H40.9

    Unspecified glaucoma

      2016 2017 2018 2019 Billable/Specific Code
    • in (due to)
      • amyloidosis E85.4
  • Glomerulonephritis N05.9
    - see also Nephritis
    ICD-10-CM Diagnosis Code N05.9

    Unspecified nephritic syndrome with unspecified morphologic changes

      2016 2017 2018 2019 Billable/Specific Code
    • in (due to)
      • amyloidosis E85.4
  • Lichen L28.0
    ICD-10-CM Diagnosis Code L28.0

    Lichen simplex chronicus

      2016 2017 2018 2019 Billable/Specific Code
    Applicable To
    • Circumscribed neurodermatitis
    • Lichen NOS
    • amyloidosis E85.4
  • Nephritis, nephritic (albuminuric) (azotemic) (congenital) (disseminated) (epithelial) (familial) (focal) (granulomatous) (hemorrhagic) (infantile) (nonsuppurative, excretory) (uremic) N05.9
    ICD-10-CM Diagnosis Code N05.9

    Unspecified nephritic syndrome with unspecified morphologic changes

      2016 2017 2018 2019 Billable/Specific Code
    • amyloid E85.4
  • Nephrosis, nephrotic (Epstein's) (syndrome) (congenital) N04.9
    ICD-10-CM Diagnosis Code N04.9

    Nephrotic syndrome with unspecified morphologic changes

      2016 2017 2018 2019 Billable/Specific Code
    • in
      • amyloidosis E85.4
  • Neuritis (rheumatoid) M79.2
    ICD-10-CM Diagnosis Code M79.2

    Neuralgia and neuritis, unspecified

      2016 2017 2018 2019 Billable/Specific Code
    Type 1 Excludes
    • amyloid, any site E85.4
  • Neuropathy, neuropathic G62.9
    ICD-10-CM Diagnosis Code G62.9

    Polyneuropathy, unspecified

      2016 2017 2018 2019 Billable/Specific Code
    Applicable To
    • Neuropathy NOS
    • peripheral (nerve) G62.9
      - see also Polyneuropathy
      ICD-10-CM Diagnosis Code G62.9

      Polyneuropathy, unspecified

        2016 2017 2018 2019 Billable/Specific Code
      Applicable To
      • Neuropathy NOS
      • autonomic G90.9
        ICD-10-CM Diagnosis Code G90.9

        Disorder of the autonomic nervous system, unspecified

          2016 2017 2018 2019 Billable/Specific Code
        • in (due to)
          • amyloidosis E85.4

ICD-10-CM Codes Adjacent To E85.4
E84.1 Cystic fibrosis with intestinal manifestations
E84.11 Meconium ileus in cystic fibrosis
E84.19 Cystic fibrosis with other intestinal manifestations
E84.8 Cystic fibrosis with other manifestations
E84.9 Cystic fibrosis, unspecified
E85 Amyloidosis
E85.0 Non-neuropathic heredofamilial amyloidosis
E85.1 Neuropathic heredofamilial amyloidosis
E85.2 Heredofamilial amyloidosis, unspecified
E85.3 Secondary systemic amyloidosis
E85.4 Organ-limited amyloidosis
E85.8 Other amyloidosis
E85.81 Light chain (AL) amyloidosis
E85.82 Wild-type transthyretin-related (ATTR) amyloidosis
E85.89 Other amyloidosis
E85.9 Amyloidosis, unspecified
E86 Volume depletion
E86.0 Dehydration
E86.1 Hypovolemia
E86.9 Volume depletion, unspecified
E87 Other disorders of fluid, electrolyte and acid-base balance

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.