ICD-10-CM Codes
E00-E89 Endocrine, nutritional and metabolic diseases
E70-E88 Metabolic disorders
E88- Other and unspecified metabolic disorders
2023 ICD-10-CM Diagnosis Code E88.02

2023 ICD-10-CM Diagnosis Code E88.02

Plasminogen deficiency

2019 - New Code

2020

2021

2022

2023

Billable/Specific Code

E88.02 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
The 2023 edition of ICD-10-CM E88.02 became effective on October 1, 2022.
This is the American ICD-10-CM version of E88.02 - other international versions of ICD-10 E88.02 may differ.

Applicable To

Dysplasminogenemia
Hypoplasminogenemia
Type 1 plasminogen deficiency
Type 2 plasminogen deficiency

Use Additional

Use Additional Help

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.

code for associated findings, such as:
hydrocephalus (
ICD-10-CM Diagnosis Code G91.4
Hydrocephalus in diseases classified elsewhere
Code First
- underlying condition, such as:
- congenital syphilis (A50.4-)
- neoplasm (C00-D49)
- plasminogen deficiency (E88.02)
Type 1 Excludes
- hydrocephalus due to congenital toxoplasmosis (P37.1)
G91.4
)
otitis media (
ICD-10-CM Diagnosis Code H67
- H67 Otitis media in diseases classified elsewhere...
  - H67.1 Otitis media in diseases classified elsewhere...
  - H67.2 Otitis media in diseases classified elsewhere...
  - H67.3 Otitis media in diseases classified elsewhere...
  - H67.9 Otitis media in diseases classified elsewhere...
H67.-
)
respiratory disorder related to plasminogen deficiency (
ICD-10-CM Diagnosis Code J99
Respiratory disorders in diseases classified elsewhere
Code First
- underlying disease, such as:
- amyloidosis (E85.-)
- ankylosing spondylitis (M45)
- congenital syphilis (A50.5)
- cryoglobulinemia (D89.1)
- early congenital syphilis (A50.0)
- plasminogen deficiency (E88.02)
- schistosomiasis (B65.0-B65.9)
Type 1 Excludes
- respiratory disorders in:
- amebiasis (A06.5)
- blastomycosis (B40.0-B40.2)
- candidiasis (B37.1)
- coccidioidomycosis (B38.0-B38.2)
- cystic fibrosis with pulmonary manifestations (E84.0)
- dermatomyositis (M33.01, M33.11)
- histoplasmosis (B39.0-B39.2)
- late syphilis (A52.72, A52.73)
- polymyositis (M33.21)
- Sjögren syndrome (M35.02)
- systemic lupus erythematosus (M32.13)
- systemic sclerosis (M34.81)
- Wegener's granulomatosis (M31.30-M31.31)
J99
)

Code Also

Code Also Help

A code also note instructs that 2 codes may be required to fully describe a condition but the sequencing of the two codes is discretionary, depending on the severity of the conditions and the reason for the encounter.

, if applicable, ligneous conjunctivitis (
ICD-10-CM Diagnosis Code H10.51
Ligneous conjunctivitis
Code Also
- underlying condition if known, such as:
- plasminogen deficiency (E88.02)
H10.51
)

The following code(s) above E88.02 contain annotation back-references

Annotation Back-References

In this context, annotation back-references refer to codes that contain:

Applicable To annotations, or
Code Also annotations, or
Code First annotations, or
Excludes1 annotations, or
Excludes2 annotations, or
Includes annotations, or
Note annotations, or
Use Additional annotations

that may be applicable to E88.02:

E00-E89
2023 ICD-10-CM Range E00-E89
Endocrine, nutritional and metabolic diseases
Note
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Type 1 Excludes
- transitory endocrine and metabolic disorders specific to newborn (P70-P74)
Endocrine, nutritional and metabolic diseases
E70-E88
2023 ICD-10-CM Range E70-E88
Metabolic disorders
Type 1 Excludes
- androgen insensitivity syndrome (E34.5-)
- congenital adrenal hyperplasia (E25.0)
- hemolytic anemias attributable to enzyme disorders (D55.-)
- Marfan's syndrome (Q87.4)
- 5-alpha-reductase deficiency (E29.1)
Type 2 Excludes
- Ehlers-Danlos syndromes (Q79.6-)
Metabolic disorders
E88
ICD-10-CM Diagnosis Code E88
Other and unspecified metabolic disorders
Type 1 Excludes
- histiocytosis X (chronic) (C96.6)
Use Additional
- codes for associated conditions
Other and unspecified metabolic disorders
E88.0
ICD-10-CM Diagnosis Code E88.0
Disorders of plasma-protein metabolism, not elsewhere classified
Type 1 Excludes
- monoclonal gammopathy (of undetermined significance) (D47.2)
- polyclonal hypergammaglobulinemia (D89.0)
- Waldenström macroglobulinemia (C88.0)
Type 2 Excludes
- disorder of lipoprotein metabolism (E78.-)
Disorders of plasma-protein metabolism, not elsewhere classified

ICD-10-CM E88.02 is grouped within Diagnostic Related Group(s) (MS-DRG v40.0):

826 Myeloproliferative disorders or poorly differentiated neoplasms with major o.r. Procedures with mcc
827 Myeloproliferative disorders or poorly differentiated neoplasms with major o.r. Procedures with cc
828 Myeloproliferative disorders or poorly differentiated neoplasms with major o.r. Procedures without cc/mcc
829 Myeloproliferative disorders or poorly differentiated neoplasms with other procedures with cc/mcc
830 Myeloproliferative disorders or poorly differentiated neoplasms with other procedures without cc/mcc
843 Other myeloproliferative disorders or poorly differentiated neoplastic diagnoses with mcc
844 Other myeloproliferative disorders or poorly differentiated neoplastic diagnoses with cc
845 Other myeloproliferative disorders or poorly differentiated neoplastic diagnoses without cc/mcc

Code History

2019 (effective 10/1/2018): New code
2020 (effective 10/1/2019): No change
2021 (effective 10/1/2020): No change
2022 (effective 10/1/2021): No change
2023 (effective 10/1/2022): No change

Code annotations containing back-references to E88.02:

Code Also: H10.51

ICD-10-CM Diagnosis Code H10.51
Ligneous conjunctivitis
Code Also
- underlying condition if known, such as:
- plasminogen deficiency (E88.02)
Code First: H67
, G91.4
, J99

ICD-10-CM Diagnosis Code H67
Otitis media in diseases classified elsewhere
Code First
- underlying disease, such as:
- plasminogen deficiency (E88.02)
- viral disease NEC (B00-B34)
Type 1 Excludes
- otitis media in:
- influenza (J09.X9, J10.83, J11.83)
- measles (B05.3)
- scarlet fever (A38.0)
- tuberculosis (A18.6)
Use Additional
- code for any associated perforated tympanic membrane (H72.-)
ICD-10-CM Diagnosis Code G91.4
Hydrocephalus in diseases classified elsewhere
Code First
- underlying condition, such as:
- congenital syphilis (A50.4-)
- neoplasm (C00-D49)
- plasminogen deficiency (E88.02)
Type 1 Excludes
- hydrocephalus due to congenital toxoplasmosis (P37.1)
ICD-10-CM Diagnosis Code J99
Respiratory disorders in diseases classified elsewhere
Code First
- underlying disease, such as:
- amyloidosis (E85.-)
- ankylosing spondylitis (M45)
- congenital syphilis (A50.5)
- cryoglobulinemia (D89.1)
- early congenital syphilis (A50.0)
- plasminogen deficiency (E88.02)
- schistosomiasis (B65.0-B65.9)
Type 1 Excludes
- respiratory disorders in:
- amebiasis (A06.5)
- blastomycosis (B40.0-B40.2)
- candidiasis (B37.1)
- coccidioidomycosis (B38.0-B38.2)
- cystic fibrosis with pulmonary manifestations (E84.0)
- dermatomyositis (M33.01, M33.11)
- histoplasmosis (B39.0-B39.2)
- late syphilis (A52.72, A52.73)
- polymyositis (M33.21)
- Sjögren syndrome (M35.02)
- systemic lupus erythematosus (M32.13)
- systemic sclerosis (M34.81)
- Wegener's granulomatosis (M31.30-M31.31)

Diagnosis Index entries containing back-references to E88.02:

Deficiency, deficient
- plasminogen E88.02 (type 1) (type 2)
Dysplasminogenemia E88.02
Hypoplasminogenemia E88.02

ICD-10-CM Codes Adjacent To E88.02

E87.5 Hyperkalemia

E87.6 Hypokalemia

E87.7 Fluid overload

E87.70 …… unspecified

E87.71 Transfusion associated circulatory overload

E87.79 Other fluid overload

E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified

E88 Other and unspecified metabolic disorders

E88.0 Disorders of plasma-protein metabolism, not elsewhere classified

E88.01 Alpha-1-antitrypsin deficiency

E88.02 Plasminogen deficiency

E88.09 Other disorders of plasma-protein metabolism, not elsewhere classified

E88.1 Lipodystrophy, not elsewhere classified

E88.2 Lipomatosis, not elsewhere classified

E88.3 Tumor lysis syndrome

E88.4 Mitochondrial metabolism disorders

E88.40 Mitochondrial metabolism disorder, unspecified

E88.41 MELAS syndrome

E88.42 MERRF syndrome

E88.49 Other mitochondrial metabolism disorders

E88.8 Other specified metabolic disorders

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

2023 ICD-10-CM Diagnosis Code E88.02

Plasminogen deficiency

Hydrocephalus in diseases classified elsewhere

Respiratory disorders in diseases classified elsewhere

Ligneous conjunctivitis

Endocrine, nutritional and metabolic diseases

Metabolic disorders

Other and unspecified metabolic disorders

Disorders of plasma-protein metabolism, not elsewhere classified

Ligneous conjunctivitis

Otitis media in diseases classified elsewhere

Hydrocephalus in diseases classified elsewhere

Respiratory disorders in diseases classified elsewhere