2020 ICD-10-CM Diagnosis Code E88.1

Lipodystrophy, not elsewhere classified

    2016 2017 2018 2019 2020 Billable/Specific Code
  • E88.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2020 edition of ICD-10-CM E88.1 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of E88.1 - other international versions of ICD-10 E88.1 may differ.
Applicable To
  • Lipodystrophy NOS
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as E88.1. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • Whipple's disease (
    ICD-10-CM Diagnosis Code K90.81

    Whipple's disease

      2016 2017 2018 2019 2020 Billable/Specific Code
    K90.81
    )
The following code(s) above E88.1 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to E88.1:
  • E00-E89
    2020 ICD-10-CM Range E00-E89

    Endocrine, nutritional and metabolic diseases

    Note
    • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Type 1 Excludes
    • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    Endocrine, nutritional and metabolic diseases
  • E70-E88
    2020 ICD-10-CM Range E70-E88

    Metabolic disorders

    Type 1 Excludes
    • androgen insensitivity syndrome (E34.5-)
    • congenital adrenal hyperplasia (E25.0)
    • Ehlers-Danlos syndrome (Q79.6-)
    • hemolytic anemias attributable to enzyme disorders (D55.-)
    • Marfan's syndrome (Q87.4)
    • 5-alpha-reductase deficiency (E29.1)
    Metabolic disorders
  • E88
    ICD-10-CM Diagnosis Code E88

    Other and unspecified metabolic disorders

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • histiocytosis X (chronic) (C96.6)
    Use Additional
    • codes for associated conditions
    Other and unspecified metabolic disorders
Approximate Synonyms
  • Congenital lipodystrophy
  • Familial partial lipodystrophy
  • Hiv lipoatrophy
  • Lipoatrophy due to hiv infection and treatment
  • Lipodystrophy
  • Lipodystrophy of face
  • Lipodystrophy, congenital
  • Lipodystrophy, facial
Clinical Information
  • A collection of heterogenous conditions resulting from defective lipid metabolism and characterized by adipose tissue atrophy. Often there is redistribution of body fat resulting in peripheral fat wasting and central adiposity. They include generalized, localized, congenital, and acquired lipodystrophy.
  • A congenital or acquired disorder characterized by abnormal loss or redistribution of the adipose tissue in the body.
  • Collection of rare conditions resulting from defective fat metabolism and characterized by atrophy of the subcutaneous fat; includes total, congenital or acquired, partial, abdominal infantile, and localized lipodystrophy.
ICD-10-CM E88.1 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0):
  • 642 Inborn and other disorders of metabolism

Convert E88.1 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change

Diagnosis Index entries containing back-references to E88.1:
  • Barraquer E88.1 (-Simons) disease or syndrome (progressive lipodystrophy)
  • Disease, diseased - see also Syndrome
    • Barraquer E88.1 (-Simons') (progressive lipodystrophy)
    • Simons' E88.1 (progressive lipodystrophy)
  • Lipodystrophia progressiva E88.1
  • Lipodystrophy (progressive) E88.1
    • insulin E88.1
  • Simons' disease or syndrome E88.1 (progressive lipodystrophy)
  • Syndrome - see also Disease
    • Hollander-Simons E88.1
    • Simons' E88.1

ICD-10-CM Codes Adjacent To E88.1
E87.7 Fluid overload
E87.70 …… unspecified
E87.71 Transfusion associated circulatory overload
E87.79 Other fluid overload
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
E88 Other and unspecified metabolic disorders
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
E88.01 Alpha-1-antitrypsin deficiency
E88.02 Plasminogen deficiency
E88.09 Other disorders of plasma-protein metabolism, not elsewhere classified
E88.1 Lipodystrophy, not elsewhere classified
E88.2 Lipomatosis, not elsewhere classified
E88.3 Tumor lysis syndrome
E88.4 Mitochondrial metabolism disorders
E88.40 Mitochondrial metabolism disorder, unspecified
E88.41 MELAS syndrome
E88.42 MERRF syndrome
E88.49 Other mitochondrial metabolism disorders
E88.8 Other specified metabolic disorders
E88.81 Metabolic syndrome
E88.89 Other specified metabolic disorders

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.