2023 ICD-10-CM Diagnosis Code I51.81

Takotsubo syndrome

    2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  • I51.81 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2023 edition of ICD-10-CM I51.81 became effective on October 1, 2022.
  • This is the American ICD-10-CM version of I51.81 - other international versions of ICD-10 I51.81 may differ.
Applicable To
  • Reversible left ventricular dysfunction following sudden emotional stress
  • Stress induced cardiomyopathy
  • Takotsubo cardiomyopathy
  • Transient left ventricular apical ballooning syndrome
The following code(s) above I51.81 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to I51.81:
  • I00-I99
    2023 ICD-10-CM Range I00-I99

    Diseases of the circulatory system

    Type 2 Excludes
    • certain conditions originating in the perinatal period (P04-P96)
    • certain infectious and parasitic diseases (A00-B99)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    • systemic connective tissue disorders (M30-M36)
    • transient cerebral ischemic attacks and related syndromes (G45.-)
    Diseases of the circulatory system
  • I51
    ICD-10-CM Diagnosis Code I51

    Complications and ill-defined descriptions of heart disease

      2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
    Type 1 Excludes
    Complications and ill-defined descriptions of heart disease
Approximate Synonyms
  • Takotsubo cardiomyopathy
Clinical Information
  • A rare disorder characterized by transient left ventricular wall systolic dysfunction, resulting in apical ballooning appearance, chest pain, and st segment elevation.
  • A transient left ventricular apical dysfunction or ballooning accompanied by electrocardiographic (ecg) t wave inversions. This abnormality is associated with high levels of catecholamines, either administered or endogenously secreted from a tumor or during extreme stress.
ICD-10-CM I51.81 is grouped within Diagnostic Related Group(s) (MS-DRG v40.0):
  • 314 Other circulatory system diagnoses with mcc
  • 315 Other circulatory system diagnoses with cc
  • 316 Other circulatory system diagnoses without cc/mcc

Convert I51.81 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
Code annotations containing back-references to I51.81:
  • Code First: I5A
    ICD-10-CM Diagnosis Code I5A

    Non-ischemic myocardial injury (non-traumatic)

      2022 - New Code 2023 Billable/Specific Code
    Applicable To
    • Acute (non-ischemic) myocardial injury
    • Chronic (non-ischemic) myocardial injury
    • Unspecified (non-ischemic) myocardial injury
    Code First
    • the underlying cause, if known and applicable, such as:
    • acute kidney failure (N17.-)
    • acute myocarditis (I40.-)
    • cardiomyopathy (I42.-)
    • chronic kidney disease (CKD) (N18.-)
    • heart failure (I50.-)
    • hypertensive urgency (I16.0)
    • nonrheumatic aortic valve disorders (I35.-)
    • paroxysmal tachycardia (I47.-)
    • pulmonary embolism (I26.-)
    • pulmonary hypertension (I27.0, I27.2-)
    • sepsis (A41.-)
    • takotsubo syndrome (I51.81)
    Type 1 Excludes
    • acute myocardial infarction (I21.-)
    • injury of heart (S26.-)
    Type 2 Excludes
    • other acute ischemic heart diseases (I24.-)

Diagnosis Index entries containing back-references to I51.81:
  • Cardiomyopathy (familial) (idiopathic) I42.9
    ICD-10-CM Diagnosis Code I42.9

    Cardiomyopathy, unspecified

      2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
    Applicable To
    • Cardiomyopathy (primary) (secondary) NOS
    • stress induced I51.81
    • takotsubo I51.81
  • Dysfunction
    • ventricular I51.9
      ICD-10-CM Diagnosis Code I51.9

      Heart disease, unspecified

        2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
      • left, reversible, following sudden emotional stress I51.81
    • left ventricular, following sudden emotional stress I51.81
  • Syndrome - see also Disease
    • apical ballooning I51.81 (transient left ventricular)
    • takotsubo I51.81
    • transient left ventricular apical ballooning I51.81

ICD-10-CM Codes Adjacent To I51.81
I50.9 Heart failure, unspecified
I51 Complications and ill-defined descriptions of heart disease
I51.0 Cardiac septal defect, acquired
I51.1 Rupture of chordae tendineae, not elsewhere classified
I51.2 Rupture of papillary muscle, not elsewhere classified
I51.3 Intracardiac thrombosis, not elsewhere classified
I51.4 Myocarditis, unspecified
I51.5 Myocardial degeneration
I51.7 Cardiomegaly
I51.8 Other ill-defined heart diseases
I51.81 Takotsubo syndrome
I51.89 Other ill-defined heart diseases
I51.9 Heart disease, unspecified
I52 Other heart disorders in diseases classified elsewhere
I5A Non-ischemic myocardial injury (non-traumatic)
I60 Nontraumatic subarachnoid hemorrhage
I60.0 Nontraumatic subarachnoid hemorrhage from carotid siphon and bifurcation
I60.00 Nontraumatic subarachnoid hemorrhage from unspecified carotid siphon and bifurcation
I60.01 Nontraumatic subarachnoid hemorrhage from right carotid siphon and bifurcation
I60.02 Nontraumatic subarachnoid hemorrhage from left carotid siphon and bifurcation
I60.1 Nontraumatic subarachnoid hemorrhage from middle cerebral artery

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.