ICD-10-CM Codes
K00-K95 Diseases of the digestive system
K20-K31 Diseases of esophagus, stomach and duodenum
K21- Gastro-esophageal reflux disease
2022 ICD-10-CM Diagnosis Code K21.01

2022 ICD-10-CM Diagnosis Code K21.01

Gastro-esophageal reflux disease with esophagitis, with bleeding

2021 - New Code

2022

Billable/Specific Code

K21.01 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
Short description: Gastro-esophageal reflux dis with esophagitis, with bleed
The 2022 edition of ICD-10-CM K21.01 became effective on October 1, 2021.
This is the American ICD-10-CM version of K21.01 - other international versions of ICD-10 K21.01 may differ.

The following code(s) above K21.01 contain annotation back-references

Annotation Back-References

In this context, annotation back-references refer to codes that contain:

Applicable To annotations, or
Code Also annotations, or
Code First annotations, or
Excludes1 annotations, or
Excludes2 annotations, or
Includes annotations, or
Note annotations, or
Use Additional annotations

that may be applicable to K21.01:

K00-K95
2022 ICD-10-CM Range K00-K95
Diseases of the digestive system
Type 2 Excludes
- certain conditions originating in the perinatal period (P04-P96)
- certain infectious and parasitic diseases (A00-B99)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Diseases of the digestive system
K20-K31
2022 ICD-10-CM Range K20-K31
Diseases of esophagus, stomach and duodenum
Type 2 Excludes
- hiatus hernia (K44.-)
Diseases of esophagus, stomach and duodenum
K21
ICD-10-CM Diagnosis Code K21
Gastro-esophageal reflux disease
Type 1 Excludes
- newborn esophageal reflux (P78.83)
Gastro-esophageal reflux disease

ICD-10-CM K21.01 is grouped within Diagnostic Related Group(s) (MS-DRG v39.0):

368 Major esophageal disorders with mcc
369 Major esophageal disorders with cc
370 Major esophageal disorders without cc/mcc

Code History

2021 (effective 10/1/2020): New code
2022 (effective 10/1/2021): No change

Diagnosis Index entries containing back-references to K21.01:

Allergy, allergic (reaction) (to) T78.40
ICD-10-CM Diagnosis Code T78.40
Allergy, unspecified
Applicable To
Allergic reaction NOS
Hypersensitivity NOS
- milk protein Z91.011
  - see also Allergy, food
  ICD-10-CM Diagnosis Code Z91.011
  Allergy to milk products
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code POA Exempt
  Type 1 Excludes
  lactose intolerance (E73.-)
  - gastroesophageal reflux K21.9
    - see also Reaction, adverse, food
    ICD-10-CM Diagnosis Code K21.9
    Gastro-esophageal reflux disease without esophagitis
    2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    Esophageal reflux NOS
    - with esophagitis (without bleeding) K21.00
      ICD-10-CM Diagnosis Code K21.00
      Gastro-esophageal reflux disease with esophagitis, without bleeding
      2021 - New Code 2022 Billable/Specific Code
      Applicable To
      Reflux esophagitis
      - with bleeding K21.01
Disease, diseased - see also Syndrome
- gastroesophageal reflux (GERD) K21.9
  ICD-10-CM Diagnosis Code K21.9
  Gastro-esophageal reflux disease without esophagitis
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  Applicable To
  Esophageal reflux NOS
  - with esophagitis (without bleeding) K21.00
    ICD-10-CM Diagnosis Code K21.00
    Gastro-esophageal reflux disease with esophagitis, without bleeding
    2021 - New Code 2022 Billable/Specific Code
    Applicable To
    Reflux esophagitis
    - with bleeding K21.01
Esophagitis (acute) (alkaline) (chemical) (chronic) (infectional) (necrotic) (peptic) (postoperative) (without bleeding) K20.90
ICD-10-CM Diagnosis Code K20.90
Esophagitis, unspecified without bleeding
Applicable To
Esophagitis NOS
- due to gastrointestinal reflux disease (without bleeding) K21.00
  ICD-10-CM Diagnosis Code K21.00
  Gastro-esophageal reflux disease with esophagitis, without bleeding
  2021 - New Code 2022 Billable/Specific Code
  Applicable To
  Reflux esophagitis
  - with bleeding K21.01
Reflux K21.9
ICD-10-CM Diagnosis Code K21.9
Gastro-esophageal reflux disease without esophagitis
Applicable To
Esophageal reflux NOS
- esophageal K21.9
  ICD-10-CM Diagnosis Code K21.9
  Gastro-esophageal reflux disease without esophagitis
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  Applicable To
  Esophageal reflux NOS
  - with esophagitis (without bleeding) K21.00
    ICD-10-CM Diagnosis Code K21.00
    Gastro-esophageal reflux disease with esophagitis, without bleeding
    2021 - New Code 2022 Billable/Specific Code
    Applicable To
    Reflux esophagitis
    - with bleeding K21.01
- gastroesophageal K21.9
  ICD-10-CM Diagnosis Code K21.9
  Gastro-esophageal reflux disease without esophagitis
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  Applicable To
  Esophageal reflux NOS
  - with esophagitis (without bleeding) K21.00
    ICD-10-CM Diagnosis Code K21.00
    Gastro-esophageal reflux disease with esophagitis, without bleeding
    2021 - New Code 2022 Billable/Specific Code
    Applicable To
    Reflux esophagitis
    - with bleeding K21.01
Ulcer, ulcerated, ulcerating, ulceration, ulcerative
- esophagus (peptic) K22.10
  ICD-10-CM Diagnosis Code K22.10
  Ulcer of esophagus without bleeding
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  Applicable To
  Ulcer of esophagus NOS
  - due to
    - gastrointestinal reflux disease (without bleeding) K21.00
      ICD-10-CM Diagnosis Code K21.00
      Gastro-esophageal reflux disease with esophagitis, without bleeding
      2021 - New Code 2022 Billable/Specific Code
      Applicable To
      Reflux esophagitis
      - with bleeding K21.01

ICD-10-CM Codes Adjacent To K21.01

K20.0 Eosinophilic esophagitis

K20.8 Other esophagitis

K20.80 …… without bleeding

K20.81 …… with bleeding

K20.9 Esophagitis, unspecified

K20.90 …… without bleeding

K20.91 …… with bleeding

K21 Gastro-esophageal reflux disease

K21.0 Gastro-esophageal reflux disease with esophagitis

K21.00 …… without bleeding

K21.01 …… with bleeding

K21.9 Gastro-esophageal reflux disease without esophagitis

K22 Other diseases of esophagus

K22.0 Achalasia of cardia

K22.1 Ulcer of esophagus

K22.10 …… without bleeding

K22.11 …… with bleeding

K22.2 Esophageal obstruction

K22.3 Perforation of esophagus

K22.4 Dyskinesia of esophagus

K22.5 Diverticulum of esophagus, acquired

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

2022 ICD-10-CM Diagnosis Code K21.01

Gastro-esophageal reflux disease with esophagitis, with bleeding

Diseases of the digestive system

Diseases of esophagus, stomach and duodenum

Gastro-esophageal reflux disease

Allergy, unspecified

Allergy to milk products

Gastro-esophageal reflux disease without esophagitis

Gastro-esophageal reflux disease with esophagitis, without bleeding

Gastro-esophageal reflux disease without esophagitis

Gastro-esophageal reflux disease with esophagitis, without bleeding

Esophagitis, unspecified without bleeding

Gastro-esophageal reflux disease with esophagitis, without bleeding

Gastro-esophageal reflux disease without esophagitis

Gastro-esophageal reflux disease without esophagitis

Gastro-esophageal reflux disease with esophagitis, without bleeding

Gastro-esophageal reflux disease without esophagitis

Gastro-esophageal reflux disease with esophagitis, without bleeding

Ulcer of esophagus without bleeding

Gastro-esophageal reflux disease with esophagitis, without bleeding