2022 ICD-10-CM Diagnosis Code K52.21

Food protein-induced enterocolitis syndrome

    2017 - New Code 2018 2019 2020 2021 2022 Billable/Specific Code
  • K52.21 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2022 edition of ICD-10-CM K52.21 became effective on October 1, 2021.
  • This is the American ICD-10-CM version of K52.21 - other international versions of ICD-10 K52.21 may differ.
Applicable To
  • FPIES
Use Additional
Use Additional Help
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
  • code for hypovolemic shock, if present (
    ICD-10-CM Diagnosis Code R57.1

    Hypovolemic shock

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    R57.1
    )
The following code(s) above K52.21 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to K52.21:
  • K00-K95
    2022 ICD-10-CM Range K00-K95

    Diseases of the digestive system

    Type 2 Excludes
    • certain conditions originating in the perinatal period (P04-P96)
    • certain infectious and parasitic diseases (A00-B99)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the digestive system
  • K50-K52
    2022 ICD-10-CM Range K50-K52

    Noninfective enteritis and colitis

    Includes
    • noninfective inflammatory bowel disease
    Type 1 Excludes
    Noninfective enteritis and colitis
  • K52.2
    ICD-10-CM Diagnosis Code K52.2

    Allergic and dietetic gastroenteritis and colitis

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Applicable To
    • Food hypersensitivity gastroenteritis or colitis
    Type 2 Excludes
    • allergic eosinophilic colitis (K52.82)
    • allergic eosinophilic esophagitis (K20.0)
    • allergic eosinophilic gastritis (K52.81)
    • allergic eosinophilic gastroenteritis (K52.81)
    Use Additional
    Allergic and dietetic gastroenteritis and colitis
ICD-10-CM K52.21 is grouped within Diagnostic Related Group(s) (MS-DRG v39.0):
  • 391 Esophagitis, gastroenteritis and miscellaneous digestive disorders with mcc
  • 392 Esophagitis, gastroenteritis and miscellaneous digestive disorders without mcc

Convert K52.21 to ICD-9-CM

Code History
  • 2017 (effective 10/1/2016): New code
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
Code annotations containing back-references to K52.21:
  • Type 1 Excludes: T61
    , T62
    , T78.4
    ICD-10-CM Diagnosis Code T61

    Toxic effect of noxious substances eaten as seafood

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • allergic reaction to food, such as:
    • anaphylactic reaction or shock due to adverse food reaction (T78.0-)
    • bacterial foodborne intoxications (A05.-)
    • dermatitis (L23.6, L25.4, L27.2)
    • food protein-induced enterocolitis syndrome (K52.21)
    • food protein-induced enteropathy (K52.22)
    • gastroenteritis (noninfective) (K52.29)
    • toxic effect of aflatoxin and other mycotoxins (T64)
    • toxic effect of cyanides (T65.0-)
    • toxic effect of harmful algae bloom (T65.82-)
    • toxic effect of hydrogen cyanide (T57.3-)
    • toxic effect of mercury (T56.1-)
    • toxic effect of red tide (T65.82-)
    ICD-10-CM Diagnosis Code T62

    Toxic effect of other noxious substances eaten as food

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • allergic reaction to food, such as:
    • anaphylactic shock (reaction) due to adverse food reaction (T78.0-)
    • bacterial food borne intoxications (A05.-)
    • dermatitis (L23.6, L25.4, L27.2)
    • food protein-induced enterocolitis syndrome (K52.21)
    • food protein-induced enteropathy (K52.22)
    • gastroenteritis (noninfective) (K52.29)
    • toxic effect of aflatoxin and other mycotoxins (T64)
    • toxic effect of cyanides (T65.0-)
    • toxic effect of hydrogen cyanide (T57.3-)
    • toxic effect of mercury (T56.1-)
    ICD-10-CM Diagnosis Code T78.4

    Other and unspecified allergy

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • specified types of allergic reaction such as:
    • allergic diarrhea (K52.29)
    • allergic gastroenteritis and colitis (K52.29)
    • dermatitis (L23-L25, L27.-)
    • food protein-induced enterocolitis syndrome (K52.21)
    • food protein-induced enteropathy (K52.22)
    • hay fever (J30.1)
  • Type 2 Excludes: T78.1
    , K52.82
    ICD-10-CM Diagnosis Code T78.1

    Other adverse food reactions, not elsewhere classified

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • anaphylactic reaction or shock due to adverse food reaction (T78.0-)
    • anaphylactic reaction due to food (T78.0-)
    • bacterial food borne intoxications (A05.-)
    Type 2 Excludes
    • allergic and dietetic gastroenteritis and colitis (K52.29)
    • allergic rhinitis due to food (J30.5)
    • dermatitis due to food in contact with skin (L23.6, L24.6, L25.4)
    • dermatitis due to ingested food (L27.2)
    • food protein-induced enterocolitis syndrome (K52.21)
    • food protein-induced enteropathy (K52.22)
    Use Additional
    • code to identify the type of reaction, if applicable
    ICD-10-CM Diagnosis Code K52.82

    Eosinophilic colitis

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Type 2 Excludes
    • allergic proctocolitis (K52.29)
    • food-induced eosinophilic proctocolitis (K52.29)
    • food protein-induced enterocolitis syndrome (FPIES) (K52.21)
    • food protein-induced proctocolitis (K52.29)
    • milk protein-induced proctocolitis (K52.29)

Diagnosis Index entries containing back-references to K52.21:
  • Allergy, allergic (reaction) (to) T78.40
    ICD-10-CM Diagnosis Code T78.40

    Allergy, unspecified

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Applicable To
    • Allergic reaction NOS
    • Hypersensitivity NOS
    • milk protein Z91.011
      - see also Allergy, food
      ICD-10-CM Diagnosis Code Z91.011

      Allergy to milk products

        2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code POA Exempt
      Type 1 Excludes
      • lactose intolerance (E73.-)
      • enterocolitis syndrome K52.21
  • Colitis (acute) (catarrhal) (chronic) (noninfective) (hemorrhagic) K52.9
    - see also Enteritis
    ICD-10-CM Diagnosis Code K52.9

    Noninfective gastroenteritis and colitis, unspecified

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Colitis NOS
    • Enteritis NOS
    • Gastroenteritis NOS
    • Ileitis NOS
    • Jejunitis NOS
    • Sigmoiditis NOS
    Type 1 Excludes
    • diarrhea NOS (R19.7)
    • functional diarrhea (K59.1)
    • infectious gastroenteritis and colitis NOS (A09)
    • neonatal diarrhea (noninfective) (P78.3)
    • psychogenic diarrhea (F45.8)
    • allergic K52.29
      ICD-10-CM Diagnosis Code K52.29

      Other allergic and dietetic gastroenteritis and colitis

        2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
      Applicable To
      • Allergic proctocolitis
      • Food hypersensitivity gastroenteritis or colitis
      • Food-induced eosinophilic proctocolitis
      • Food protein-induced proctocolitis
      • Immediate gastrointestinal hypersensitivity
      • Milk protein-induced proctocolitis
      • with
        • food protein-induced enterocolitis syndrome K52.21
  • Enteritis (acute) (diarrheal) (hemorrhagic) (noninfective) K52.9
    ICD-10-CM Diagnosis Code K52.9

    Noninfective gastroenteritis and colitis, unspecified

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Colitis NOS
    • Enteritis NOS
    • Gastroenteritis NOS
    • Ileitis NOS
    • Jejunitis NOS
    • Sigmoiditis NOS
    Type 1 Excludes
    • diarrhea NOS (R19.7)
    • functional diarrhea (K59.1)
    • infectious gastroenteritis and colitis NOS (A09)
    • neonatal diarrhea (noninfective) (P78.3)
    • psychogenic diarrhea (F45.8)
    • allergic K52.29
      ICD-10-CM Diagnosis Code K52.29

      Other allergic and dietetic gastroenteritis and colitis

        2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
      Applicable To
      • Allergic proctocolitis
      • Food hypersensitivity gastroenteritis or colitis
      • Food-induced eosinophilic proctocolitis
      • Food protein-induced proctocolitis
      • Immediate gastrointestinal hypersensitivity
      • Milk protein-induced proctocolitis
      • with
        • food protein-induced enterocolitis syndrome K52.21
        • FPIES K52.21
  • FPIES K52.21 (food protein-induced enterocolitis syndrome)
  • Gastroenteritis (acute) (chronic) (noninfectious) K52.9
    - see also Enteritis
    ICD-10-CM Diagnosis Code K52.9

    Noninfective gastroenteritis and colitis, unspecified

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Colitis NOS
    • Enteritis NOS
    • Gastroenteritis NOS
    • Ileitis NOS
    • Jejunitis NOS
    • Sigmoiditis NOS
    Type 1 Excludes
    • diarrhea NOS (R19.7)
    • functional diarrhea (K59.1)
    • infectious gastroenteritis and colitis NOS (A09)
    • neonatal diarrhea (noninfective) (P78.3)
    • psychogenic diarrhea (F45.8)
    • allergic K52.29
      ICD-10-CM Diagnosis Code K52.29

      Other allergic and dietetic gastroenteritis and colitis

        2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
      Applicable To
      • Allergic proctocolitis
      • Food hypersensitivity gastroenteritis or colitis
      • Food-induced eosinophilic proctocolitis
      • Food protein-induced proctocolitis
      • Immediate gastrointestinal hypersensitivity
      • Milk protein-induced proctocolitis
      • with
        • food protein-induced enterocolitis syndrome K52.21
  • Syndrome - see also Disease
    • food protein-induced enterocolitis K52.21 (FPIES)

ICD-10-CM Codes Adjacent To K52.21
K51.911 Ulcerative colitis, unspecified with rectal bleeding
K51.912 Ulcerative colitis, unspecified with intestinal obstruction
K51.913 Ulcerative colitis, unspecified with fistula
K51.914 Ulcerative colitis, unspecified with abscess
K51.918 Ulcerative colitis, unspecified with other complication
K51.919 Ulcerative colitis, unspecified with unspecified complications
K52 Other and unspecified noninfective gastroenteritis and colitis
K52.0 Gastroenteritis and colitis due to radiation
K52.1 Toxic gastroenteritis and colitis
K52.2 Allergic and dietetic gastroenteritis and colitis
K52.21 Food protein-induced enterocolitis syndrome
K52.22 Food protein-induced enteropathy
K52.29 Other allergic and dietetic gastroenteritis and colitis
K52.3 Indeterminate colitis
K52.8 Other specified noninfective gastroenteritis and colitis
K52.81 Eosinophilic gastritis or gastroenteritis
K52.82 Eosinophilic colitis
K52.83 Microscopic colitis
K52.831 Collagenous colitis
K52.832 Lymphocytic colitis
K52.838 Other microscopic colitis

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.