2022 ICD-10-CM Diagnosis Code K76.5

Hepatic veno-occlusive disease

    2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  • K76.5 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2022 edition of ICD-10-CM K76.5 became effective on October 1, 2021.
  • This is the American ICD-10-CM version of K76.5 - other international versions of ICD-10 K76.5 may differ.
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as K76.5. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • Budd-Chiari syndrome (
    ICD-10-CM Diagnosis Code I82.0

    Budd-Chiari syndrome

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Hepatic vein thrombosis
    I82.0
    )
The following code(s) above K76.5 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to K76.5:
  • K00-K95
    2022 ICD-10-CM Range K00-K95

    Diseases of the digestive system

    Type 2 Excludes
    • certain conditions originating in the perinatal period (P04-P96)
    • certain infectious and parasitic diseases (A00-B99)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the digestive system
  • K70-K77
    2022 ICD-10-CM Range K70-K77

    Diseases of liver

    Type 1 Excludes
    • jaundice NOS (R17)
    Type 2 Excludes
    Diseases of liver
  • K76
    ICD-10-CM Diagnosis Code K76

    Other diseases of liver

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Type 2 Excludes
    • alcoholic liver disease (K70.-)
    • amyloid degeneration of liver (E85.-)
    • cystic disease of liver (congenital) (Q44.6)
    • hepatic vein thrombosis (I82.0)
    • hepatomegaly NOS (R16.0)
    • pigmentary cirrhosis (of liver) (E83.110)
    • portal vein thrombosis (I81)
    • toxic liver disease (K71.-)
    Other diseases of liver
Approximate Synonyms
  • Veno-occlusive disease of the liver
Clinical Information
  • A condition in which some of the veins in the liver are blocked. It is sometimes a complication of high-dose chemotherapy given before a bone marrow transplant and is marked by increases in weight, liver size, and blood levels of bilirubin.
  • A disorder characterized by damage of the hepatic sinusoidal endothelial cells of the hepatic venules that leads to venular occlusion and hepatocellular necrosis. It is usually the side effect of high dose chemotherapy in preparation for stem cell transplantation. Less frequently it may be caused by ingestion of plant alkaloids. The clinical signs and symptoms include hyperbilirubinemia, hepatomegaly, and fluid retention.
  • Liver disease that is caused by injuries to the endothelial cells of the vessels and subendothelial edema, but not by thrombosis. Extracellular matrix, rich in fibronectins, is usually deposited around the hepatic veins leading to venous outflow occlusion and sinusoidal obstruction.
ICD-10-CM K76.5 is grouped within Diagnostic Related Group(s) (MS-DRG v39.0):
  • 441 Disorders of liver except malignancy, cirrhosis or alcoholic hepatitis with mcc
  • 442 Disorders of liver except malignancy, cirrhosis or alcoholic hepatitis with cc
  • 443 Disorders of liver except malignancy, cirrhosis or alcoholic hepatitis without cc/mcc

Convert K76.5 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
Code annotations containing back-references to K76.5:
  • Use Additional: M31.11
    , M31.11
    ICD-10-CM Diagnosis Code M31.11

    Hematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA]

      2022 - New Code Billable/Specific Code
    Applicable To
    • Transplant-associated thrombotic microangiopathy [TA-TMA]
    Code First
    • if applicable:
    • complications of bone marrow transplant (T86.0-)
    • complications of stem cell transplant (T86.5)
    Use Additional
    • code to identify specific organ dysfunction, such as:
    • acute kidney failure (N17.-)
    • acute respiratory distress syndrome (J80)
    • capillary leak syndrome (I78.8)
    • diffuse alveolar hemorrhage (R04.89)
    • encephalopathy (metabolic) (septic) (G93.41)
    • fluid overload, unspecified (E87.70)
    • graft versus host disease (D89.81-)
    • hemolytic uremic syndrome (D59.3)
    • hepatic failure (K72.-)
    • hepatic veno-occlusive disease (K76.5)
    • idiopathic interstitial pneumonia (J84.11-)
    • sinusoidal obstruction syndrome (K76.5)
    ICD-10-CM Diagnosis Code M31.11

    Hematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA]

      2022 - New Code Billable/Specific Code
    Applicable To
    • Transplant-associated thrombotic microangiopathy [TA-TMA]
    Code First
    • if applicable:
    • complications of bone marrow transplant (T86.0-)
    • complications of stem cell transplant (T86.5)
    Use Additional
    • code to identify specific organ dysfunction, such as:
    • acute kidney failure (N17.-)
    • acute respiratory distress syndrome (J80)
    • capillary leak syndrome (I78.8)
    • diffuse alveolar hemorrhage (R04.89)
    • encephalopathy (metabolic) (septic) (G93.41)
    • fluid overload, unspecified (E87.70)
    • graft versus host disease (D89.81-)
    • hemolytic uremic syndrome (D59.3)
    • hepatic failure (K72.-)
    • hepatic veno-occlusive disease (K76.5)
    • idiopathic interstitial pneumonia (J84.11-)
    • sinusoidal obstruction syndrome (K76.5)

Diagnosis Index entries containing back-references to K76.5:
  • Disease, diseased - see also Syndrome
    • liver (chronic) (organic) K76.9
      ICD-10-CM Diagnosis Code K76.9

      Liver disease, unspecified

        2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
      • veno-occlusive K76.5

ICD-10-CM Codes Adjacent To K76.5
K75.8 Other specified inflammatory liver diseases
K75.81 Nonalcoholic steatohepatitis (NASH)
K75.89 Other specified inflammatory liver diseases
K75.9 Inflammatory liver disease, unspecified
K76 Other diseases of liver
K76.0 Fatty (change of) liver, not elsewhere classified
K76.1 Chronic passive congestion of liver
K76.2 Central hemorrhagic necrosis of liver
K76.3 Infarction of liver
K76.4 Peliosis hepatis
K76.5 Hepatic veno-occlusive disease
K76.6 Portal hypertension
K76.7 Hepatorenal syndrome
K76.8 Other specified diseases of liver
K76.81 Hepatopulmonary syndrome
K76.89 Other specified diseases of liver
K76.9 Liver disease, unspecified
K77 Liver disorders in diseases classified elsewhere
K80 Cholelithiasis
K80.0 Calculus of gallbladder with acute cholecystitis
K80.00 …… without obstruction

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.