2021 ICD-10-CM Diagnosis Code M31.1

Thrombotic microangiopathy

    2016 2017 2018 2019 2020 2021 Billable/Specific Code
  • M31.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2021 edition of ICD-10-CM M31.1 became effective on October 1, 2020.
  • This is the American ICD-10-CM version of M31.1 - other international versions of ICD-10 M31.1 may differ.
Applicable To
  • Thrombotic thrombocytopenic purpura
The following code(s) above M31.1 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to M31.1:
  • M00-M99
    2021 ICD-10-CM Range M00-M99

    Diseases of the musculoskeletal system and connective tissue

    Note
    • Use an external cause code following the code for the musculoskeletal condition, if applicable, to identify the cause of the musculoskeletal condition
    Type 2 Excludes
    • arthropathic psoriasis (L40.5-)
    • certain conditions originating in the perinatal period (P04-P96)
    • certain infectious and parasitic diseases (A00-B99)
    • compartment syndrome (traumatic) (T79.A-)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the musculoskeletal system and connective tissue
  • M30-M36
    2021 ICD-10-CM Range M30-M36

    Systemic connective tissue disorders

    Includes
    • autoimmune disease NOS
    • collagen (vascular) disease NOS
    • systemic autoimmune disease
    • systemic collagen (vascular) disease
    Type 1 Excludes
    • autoimmune disease, single organ or single cell-type -code to relevant condition category
    Systemic connective tissue disorders
Approximate Synonyms
  • Thrombotic microangiopathic
  • Thrombotic thrombocytopenic purpura
Clinical Information
  • A disorder characterized by the presence of microangiopathic hemolytic anemia, thrombocytopenic purpura, fever, renal abnormalities and neurological abnormalities such as seizures, hemiplegia, and visual disturbances. It is an acute or subacute condition.
  • A kind of blood disorder that causes blood clots to form in blood vessels around the body
  • An acquired, congenital, or familial disorder caused by platelet aggregation with thrombosis in terminal arterioles and capillaries. Clinical features include thrombocytopenia; hemolytic anemia; azotemia; fever; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as renal failure.
  • An acute or subacute syndrome characterized by the presence of microangiopathic hemolytic anemia, thrombocytopenic purpura, fever, renal abnormalities and neurologic abnormalities such as seizures, hemiplegia, and visual disturbances. Drugs and bacteria have been implicated as etiologic factors. The introduction of plasma exchange has significantly lowered the mortality rate. If untreated, the mortality rate is high.
  • Diseases that result in thrombosis in microvasculature. The two most prominent diseases are purpura, thrombotic thrombocytopenic; and hemolytic-uremic syndrome. Multiple etiological factors include vascular endothelial cell damage due to shiga toxin; factor h deficiency; and aberrant von willebrand factor formation.
  • The syndromes of microangiopathic hemolytic anemia, thrombocytopenia, and variable signs of organ impairment, due to platelet aggregation in the microcirculation.
ICD-10-CM M31.1 is grouped within Diagnostic Related Group(s) (MS-DRG v38.0):
  • 545 Connective tissue disorders with mcc
  • 546 Connective tissue disorders with cc
  • 547 Connective tissue disorders without cc/mcc

Convert M31.1 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
Code annotations containing back-references to M31.1:
  • Type 1 Excludes: D68.5
    , D69
    ICD-10-CM Diagnosis Code D68.5

    Primary thrombophilia

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Applicable To
    • Primary hypercoagulable states
    Type 1 Excludes
    • antiphospholipid syndrome (D68.61)
    • lupus anticoagulant (D68.62)
    • secondary activated protein C resistance (D68.69)
    • secondary antiphospholipid antibody syndrome (D68.69)
    • secondary lupus anticoagulant with hypercoagulable state (D68.69)
    • secondary systemic lupus erythematosus [SLE] inhibitor with hypercoagulable state (D68.69)
    • systemic lupus erythematosus [SLE] inhibitor finding without diagnosis (R76.0)
    • systemic lupus erythematosus [SLE] inhibitor with hemorrhagic disorder (D68.312)
    • thrombotic thrombocytopenic purpura (M31.1)
    ICD-10-CM Diagnosis Code D69

    Purpura and other hemorrhagic conditions

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • benign hypergammaglobulinemic purpura (D89.0)
    • cryoglobulinemic purpura (D89.1)
    • essential (hemorrhagic) thrombocythemia (D47.3)
    • hemorrhagic thrombocythemia (D47.3)
    • purpura fulminans (D65)
    • thrombotic thrombocytopenic purpura (M31.1)
    • Waldenström hypergammaglobulinemic purpura (D89.0)

Diagnosis Index entries containing back-references to M31.1:
  • Disorder (of) - see also Disease
    • glomerular (in) N05.9
      ICD-10-CM Diagnosis Code N05.9

      Unspecified nephritic syndrome with unspecified morphologic changes

        2016 2017 2018 2019 2020 2021 Billable/Specific Code
      • thrombotic thrombocytopenic purpura M31.1
  • Glomerulonephritis N05.9
    - see also Nephritis
    ICD-10-CM Diagnosis Code N05.9

    Unspecified nephritic syndrome with unspecified morphologic changes

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    • in (due to)
      • thrombotic thrombocytopenic purpura M31.1
  • Microangiopathy (peripheral) I73.9
    ICD-10-CM Diagnosis Code I73.9

    Peripheral vascular disease, unspecified

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Intermittent claudication
    • Peripheral angiopathy NOS
    • Spasm of artery
    Type 1 Excludes
    • thrombotic M31.1
  • Moschowitz' disease M31.1
  • Purpura D69.2
    ICD-10-CM Diagnosis Code D69.2

    Other nonthrombocytopenic purpura

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Purpura NOS
    • Purpura simplex
    • Senile purpura
    • thrombocytopenic D69.49
      ICD-10-CM Diagnosis Code D69.49

      Other primary thrombocytopenia

        2016 2017 2018 2019 2020 2021 Billable/Specific Code
      Applicable To
      • Megakaryocytic hypoplasia
      • Primary thrombocytopenia NOS
      • thrombotic M31.1
    • thrombotic, thrombocytopenic M31.1

ICD-10-CM Codes Adjacent To M31.1
M27.8 Other specified diseases of jaws
M27.9 Disease of jaws, unspecified
M30 Polyarteritis nodosa and related conditions
M30.0 Polyarteritis nodosa
M30.1 Polyarteritis with lung involvement [Churg-Strauss]
M30.2 Juvenile polyarteritis
M30.3 Mucocutaneous lymph node syndrome [Kawasaki]
M30.8 Other conditions related to polyarteritis nodosa
M31 Other necrotizing vasculopathies
M31.0 Hypersensitivity angiitis
M31.1 Thrombotic microangiopathy
M31.2 Lethal midline granuloma
M31.3 Wegener's granulomatosis
M31.30 …… without renal involvement
M31.31 …… with renal involvement
M31.4 Aortic arch syndrome [Takayasu]
M31.5 Giant cell arteritis with polymyalgia rheumatica
M31.6 Other giant cell arteritis
M31.7 Microscopic polyangiitis
M31.8 Other specified necrotizing vasculopathies
M31.9 Necrotizing vasculopathy, unspecified

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.