2020 ICD-10-CM Diagnosis Code M35.1

Other overlap syndromes

    2016 2017 2018 2019 2020 Billable/Specific Code
  • M35.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2020 edition of ICD-10-CM M35.1 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of M35.1 - other international versions of ICD-10 M35.1 may differ.
Applicable To
  • Mixed connective tissue disease
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as M35.1. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • polyangiitis overlap syndrome (
    ICD-10-CM Diagnosis Code M30.8

    Other conditions related to polyarteritis nodosa

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Polyangiitis overlap syndrome
    M30.8
    )
The following code(s) above M35.1 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to M35.1:
  • M00-M99
    2020 ICD-10-CM Range M00-M99

    Diseases of the musculoskeletal system and connective tissue

    Note
    • Use an external cause code following the code for the musculoskeletal condition, if applicable, to identify the cause of the musculoskeletal condition
    Type 2 Excludes
    • arthropathic psoriasis (L40.5-)
    • certain conditions originating in the perinatal period (P04-P96)
    • certain infectious and parasitic diseases (A00-B99)
    • compartment syndrome (traumatic) (T79.A-)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the musculoskeletal system and connective tissue
  • M30-M36
    2020 ICD-10-CM Range M30-M36

    Systemic connective tissue disorders

    Includes
    • autoimmune disease NOS
    • collagen (vascular) disease NOS
    • systemic autoimmune disease
    • systemic collagen (vascular) disease
    Type 1 Excludes
    • autoimmune disease, single organ or single cell-type -code to relevant condition category
    Systemic connective tissue disorders
  • M35
    ICD-10-CM Diagnosis Code M35

    Other systemic involvement of connective tissue

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • reactive perforating collagenosis (L87.1)
    Other systemic involvement of connective tissue
Approximate Synonyms
  • Mixed collagen vascular disease
  • Mixed connective tissue disease
Clinical Information
  • A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a "speckled" epidermal nuclear staining pattern on direct immunofluorescence.
  • An autoimmune overlap syndrome characterized by the presence of symptoms of systemic lupus erythematosus, systemic scleroderma, and polymyositis.
ICD-10-CM M35.1 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0):
  • 545 Connective tissue disorders with mcc
  • 546 Connective tissue disorders with cc
  • 547 Connective tissue disorders without cc/mcc

Convert M35.1 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change

Diagnosis Index entries containing back-references to M35.1:
  • Disease, diseased - see also Syndrome
    • mixed connective tissue M35.1
  • Syndrome - see also Disease
    • connective tissue M35.9
      ICD-10-CM Diagnosis Code M35.9

      Systemic involvement of connective tissue, unspecified

        2016 2017 2018 2019 2020 Billable/Specific Code
      Applicable To
      • Autoimmune disease (systemic) NOS
      • Collagen (vascular) disease NOS
      • overlap NEC M35.1

ICD-10-CM Codes Adjacent To M35.1
M34.89 Other systemic sclerosis
M34.9 Systemic sclerosis, unspecified
M35 Other systemic involvement of connective tissue
M35.0 Sicca syndrome [Sjögren]
M35.00 Sicca syndrome, unspecified
M35.01 Sicca syndrome with keratoconjunctivitis
M35.02 Sicca syndrome with lung involvement
M35.03 Sicca syndrome with myopathy
M35.04 Sicca syndrome with tubulo-interstitial nephropathy
M35.09 Sicca syndrome with other organ involvement
M35.1 Other overlap syndromes
M35.2 Behçet's disease
M35.3 Polymyalgia rheumatica
M35.4 Diffuse (eosinophilic) fasciitis
M35.5 Multifocal fibrosclerosis
M35.6 Relapsing panniculitis [Weber-Christian]
M35.7 Hypermobility syndrome
M35.8 Other specified systemic involvement of connective tissue
M35.9 Systemic involvement of connective tissue, unspecified
M36 Systemic disorders of connective tissue in diseases classified elsewhere
M36.0 Dermato(poly)myositis in neoplastic disease

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.