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ICD-10-CM Codes
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2023 ICD-10-CM Diagnosis Code M35.81
2023 ICD-10-CM Diagnosis Code M35.81
Multisystem inflammatory syndrome
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
- M35.81 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
- The 2023 edition of ICD-10-CM M35.81 became effective on October 1, 2022.
- This is the American ICD-10-CM version of M35.81 - other international versions of ICD-10 M35.81 may differ.
Applicable To- MIS-A
- MIS-C
- Multisystem inflammatory syndrome in adults
- Multisystem inflammatory syndrome in children
- Pediatric inflammatory multisystem syndrome
- PIMS
Use AdditionalUse Additional Help
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
- code, if applicable, for:
- exposure to COVID-19 or SARS-CoV-2 infection (
ICD-10-CM Diagnosis Code Z20.822
Contact with and (suspected) exposure to COVID-19
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
Applicable To- Contact with and (suspected) exposure to SARS-CoV-2
Z20.822) - personal history of COVID-19 (
ICD-10-CM Diagnosis Code Z86.16
Personal history of COVID-19
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code POA Exempt
Type 1 Excludes- post COVID-19 condition (U09.9)
Z86.16) - post COVID-19 condition (
ICD-10-CM Diagnosis Code U09.9
Post COVID-19 condition, unspecified
2022 - New Code 2023 Billable/Specific Code
Code First- the specific condition related to COVID-19 if known, such as:
- chronic respiratory failure (J96.1-)
- loss of smell (R43.8)
- loss of taste (R43.8)
- multisystem inflammatory syndrome (M35.81)
- pulmonary embolism (I26.-)
- pulmonary fibrosis (J84.10)
Note- This code enables establishment of a link with COVID-19.
- This code is not to be used in cases that are still presenting with active COVID-19. However, an exception is made in cases of re-infection with COVID-19, occurring with a condition related to prior COVID-19.
- Post-acute sequela of COVID-19
U09.9)
Code FirstCode First Help
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
Code AlsoCode Also Help
A code also note instructs that 2 codes may be required to fully describe a condition but the sequencing of the two codes is discretionary, depending on the severity of the conditions and the reason for the encounter.
- any associated complications such as:
- acute hepatic failure (
ICD-10-CM Diagnosis Code K72.0
Acute and subacute hepatic failure
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
Applicable To- Acute non-viral hepatitis NOS
K72.0-) - acute kidney failure (
ICD-10-CM Diagnosis Code N17
- N17 Acute kidney failure
- N17.0 Acute kidney failure with tubular necrosis
- N17.1 Acute kidney failure with acute cortical necr...
- N17.2 Acute kidney failure with medullary necrosis
- N17.8 Other acute kidney failure
- N17.9 Acute kidney failure, unspecified
N17.-) - acute myocarditis (
ICD-10-CM Diagnosis Code I40
- I40 Acute myocarditis
- I40.0 Infective myocarditis
- I40.1 Isolated myocarditis
- I40.8 Other acute myocarditis
- I40.9 Acute myocarditis, unspecified
I40.-) - acute respiratory distress syndrome (
ICD-10-CM Diagnosis Code J80
Acute respiratory distress syndrome
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
Applicable To- Acute respiratory distress syndrome in adult or child
- Adult hyaline membrane disease
Type 1 Excludes- respiratory distress syndrome in newborn (perinatal) (P22.0)
J80) - cardiac arrhythmia (
ICD-10-CM Diagnosis Code I47
Paroxysmal tachycardia
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
Code First- tachycardia complicating:
- abortion or ectopic or molar pregnancy (O00-O07, O08.8)
- obstetric surgery and procedures (O75.4)
Type 1 Excludes- tachycardia NOS (R00.0)
- sinoauricular tachycardia NOS (R00.0)
- sinus [sinusal] tachycardia NOS (R00.0)
I47-ICD-10-CM Diagnosis Code I49
Other cardiac arrhythmias
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
Code First- cardiac arrhythmia complicating:
- abortion or ectopic or molar pregnancy (O00-O07, O08.8)
- obstetric surgery and procedures (O75.4)
Type 1 Excludes- neonatal dysrhythmia (P29.1-)
- sinoatrial bradycardia (R00.1)
- sinus bradycardia (R00.1)
- vagal bradycardia (R00.1)
I49.-) - pneumonia due to COVID-19 (
ICD-10-CM Diagnosis Code J12.82
Pneumonia due to coronavirus disease 2019
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
Applicable To- Pneumonia due to 2019 novel coronavirus (SARS-CoV-2)
- Pneumonia due to COVID-19
J12.82) - severe sepsis (
ICD-10-CM Diagnosis Code R65.2
Severe sepsis
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
Applicable To- Infection with associated acute organ dysfunction
- Sepsis with acute organ dysfunction
- Sepsis with multiple organ dysfunction
- Systemic inflammatory response syndrome due to infectious process with acute organ dysfunction
Code First- underlying infection, such as:
- infection following a procedure (T81.4-)
- infections following infusion, transfusion and therapeutic injection (T80.2-)
- puerperal sepsis (O85)
- sepsis following complete or unspecified spontaneous abortion (O03.87)
- sepsis following ectopic and molar pregnancy (O08.82)
- sepsis following incomplete spontaneous abortion (O03.37)
- sepsis following (induced) termination of pregnancy (O04.87)
- sepsis NOS (A41.9)
Use Additional- code to identify specific acute organ dysfunction, such as:
- acute kidney failure (N17.-)
- acute respiratory failure (J96.0-)
- critical illness myopathy (G72.81)
- critical illness polyneuropathy (G62.81)
- disseminated intravascular coagulopathy [DIC] (D65)
- encephalopathy (metabolic) (septic) (G93.41)
- hepatic failure (K72.0-)
R65.2-) - viral cardiomyopathy (
ICD-10-CM Diagnosis Code B33.24
Viral cardiomyopathy
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
B33.24) - viral pericarditis (
ICD-10-CM Diagnosis Code B33.23
Viral pericarditis
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
B33.23)
The following code(s) above
M35.81 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
- Applicable To annotations, or
- Code Also annotations, or
- Code First annotations, or
- Excludes1 annotations, or
- Excludes2 annotations, or
- Includes annotations, or
- Note annotations, or
- Use Additional annotations
that may be applicable to
M35.81:
- M00-M99
2023 ICD-10-CM Range M00-M99
Diseases of the musculoskeletal system and connective tissueNote- Use an external cause code following the code for the musculoskeletal condition, if applicable, to identify the cause of the musculoskeletal condition
Type 2 Excludes- arthropathic psoriasis (L40.5-)
- certain conditions originating in the perinatal period (P04-P96)
- certain infectious and parasitic diseases (A00-B99)
- compartment syndrome (traumatic) (T79.A-)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Diseases of the musculoskeletal system and connective tissue - M30-M36
2023 ICD-10-CM Range M30-M36
Systemic connective tissue disordersIncludes- autoimmune disease NOS
- collagen (vascular) disease NOS
- systemic autoimmune disease
- systemic collagen (vascular) disease
Type 1 Excludes- autoimmune disease, single organ or single cell-type -code to relevant condition category
Systemic connective tissue disorders - M35
ICD-10-CM Diagnosis Code M35
Other systemic involvement of connective tissue
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
Type 1 Excludes- reactive perforating collagenosis (L87.1)
Other systemic involvement of connective tissue
ICD-10-CM M35.81 is grouped within Diagnostic Related Group(s) (MS-DRG v40.0):
- 545 Connective tissue disorders with mcc
- 546 Connective tissue disorders with cc
- 547 Connective tissue disorders without cc/mcc
Convert M35.81 to ICD-9-CM
Code History
- 2016 (effective 10/1/2015): No change
- 2017 (effective 10/1/2016): No change
- 2018 (effective 10/1/2017): No change
- 2019 (effective 10/1/2018): No change
- 2020 (effective 10/1/2019): No change
- 2021 (effective 10/1/2020): No change
- 2022 (effective 10/1/2021): No change
- 2023 (effective 10/1/2022): No change
Code annotations containing back-references to M35.81:
- MIS-A M35.81
- MIS-C M35.81
- Multisystem inflammatory syndrome M35.81 (in adult) (in children)
- Pediatric inflammatory multisystem syndrome M35.81
- PIMS M35.81
- Syndrome - see also Disease
- multisystem inflammatory M35.81 (in adults) (in children)
- pediatric inflammatory multisystem M35.81
ICD-10-CM Codes Adjacent To M35.81
M35.0C …… with dental involvement
M35.09 …… with other organ involvement
M35.1 Other overlap syndromes
M35.3 Polymyalgia rheumatica
M35.4 Diffuse (eosinophilic) fasciitis
M35.5 Multifocal fibrosclerosis
M35.6 Relapsing panniculitis [Weber-Christian]
M35.7 Hypermobility syndrome
M35.8 Other specified systemic involvement of connective tissue
M35.81
Multisystem inflammatory syndrome
M35.89 Other specified systemic involvement of connective tissue
M35.9 Systemic involvement of connective tissue, unspecified
M36 Systemic disorders of connective tissue in diseases classified elsewhere
M36.0 Dermato(poly)myositis in neoplastic disease
M36.1 Arthropathy in neoplastic disease
M36.2 Hemophilic arthropathy
M36.3 Arthropathy in other blood disorders
M36.4 Arthropathy in hypersensitivity reactions classified elsewhere
M36.8 Systemic disorders of connective tissue in other diseases classified elsewhere
M40 Kyphosis and lordosis
Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.