2022 ICD-10-CM Diagnosis Code M45

Ankylosing spondylitis

    2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
  • M45 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2022 edition of ICD-10-CM M45 became effective on October 1, 2021.
  • This is the American ICD-10-CM version of M45 - other international versions of ICD-10 M45 may differ.
Applicable To
  • Rheumatoid arthritis of spine
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as M45. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • arthropathy in Reiter's disease (
    ICD-10-CM Diagnosis Code M02.3

    Reiter's disease

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Applicable To
    • Reactive arthritis
    M02.3-
    )
  • juvenile (ankylosing) spondylitis (
    ICD-10-CM Diagnosis Code M08.1

    Juvenile ankylosing spondylitis

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Type 1 Excludes
    • ankylosing spondylitis in adults (M45.0-)
    M08.1
    )
Type 2 Excludes
Type 2 Excludes Help
A type 2 excludes note represents "not included here". A type 2 excludes note indicates that the condition excluded is not part of the condition it is excluded from but a patient may have both conditions at the same time. When a type 2 excludes note appears under a code it is acceptable to use both the code (M45) and the excluded code together.
  • Behçet's disease (
    ICD-10-CM Diagnosis Code M35.2

    Behçet's disease

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    M35.2
    )
The following code(s) above M45 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to M45:
  • M00-M99
    2022 ICD-10-CM Range M00-M99

    Diseases of the musculoskeletal system and connective tissue

    Note
    • Use an external cause code following the code for the musculoskeletal condition, if applicable, to identify the cause of the musculoskeletal condition
    Type 2 Excludes
    • arthropathic psoriasis (L40.5-)
    • certain conditions originating in the perinatal period (P04-P96)
    • certain infectious and parasitic diseases (A00-B99)
    • compartment syndrome (traumatic) (T79.A-)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the musculoskeletal system and connective tissue
Clinical Information
  • A chronic inflammatory condition affecting the axial joints, such as the sacroiliac joint and other intervertebral or costovertebral joints. It occurs predominantly in young males and is characterized by pain and stiffness of joints (ankylosis) with inflammation at tendon insertions.
  • An autoimmune chronic inflammatory disorder characterized by inflammation in the vertebral joints of the spine and sacroiliac joints. It predominantly affects young males. Patients present with stiffness and pain in the spine.
  • Ankylosing spondylitis is a type of arthritis of the spine. It causes swelling between your vertebrae, which are the disks that make up your spine, and in the joints between your spine and pelvis. Ankylosing spondylitis is an immune disease. The disease is more common and more severe in men. It often runs in families. Early symptoms include back pain and stiffness. These problems often start in late adolescence or early adulthood. Over time, ankylosing spondylitis can fuse your vertebrae together, limiting movement. Symptoms can worsen or improve or stop altogether. The disease has no cure, but medicines can relieve the pain, swelling and other symptoms. Exercise can also help. nih: national institute of arthritis and musculoskeletal and skin disease
  • Chronic inflammation of the spine and the low back bone joint
Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
Code annotations containing back-references to M45:
  • Code First: J99
    ICD-10-CM Diagnosis Code J99

    Respiratory disorders in diseases classified elsewhere

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code Manifestation Code
    Code First
    • underlying disease, such as:
    • amyloidosis (E85.-)
    • ankylosing spondylitis (M45)
    • congenital syphilis (A50.5)
    • cryoglobulinemia (D89.1)
    • early congenital syphilis (A50.0)
    • plasminogen deficiency (E88.02)
    • schistosomiasis (B65.0-B65.9)
    Type 1 Excludes
  • Type 1 Excludes: G55
    , M05
    ICD-10-CM Diagnosis Code G55

    Nerve root and plexus compressions in diseases classified elsewhere

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code Manifestation Code
    Code First
    • underlying disease, such as:
    • neoplasm (C00-D49)
    Type 1 Excludes
    • nerve root compression (due to) (in) ankylosing spondylitis (M45.-)
    • nerve root compression (due to) (in) dorsopathies (M53.-, M54.-)
    • nerve root compression (due to) (in) intervertebral disc disorders (M50.1.-, M51.1.-)
    • nerve root compression (due to) (in) spondylopathies (M46.-, M48.-)
    • nerve root compression (due to) (in) spondylosis (M47.0-, M47.2.-)
    ICD-10-CM Diagnosis Code M05

    Rheumatoid arthritis with rheumatoid factor

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • rheumatic fever (I00)
    • juvenile rheumatoid arthritis (M08.-)
    • rheumatoid arthritis of spine (M45.-)
ICD-10-CM Codes Adjacent To M45
M43.8X1 …… occipito-atlanto-axial region
M43.8X2 …… cervical region
M43.8X3 …… cervicothoracic region
M43.8X4 …… thoracic region
M43.8X5 …… thoracolumbar region
M43.8X6 …… lumbar region
M43.8X7 …… lumbosacral region
M43.8X8 …… sacral and sacrococcygeal region
M43.8X9 …… site unspecified
M43.9 Deforming dorsopathy, unspecified
M45 Ankylosing spondylitis
M45.0 Ankylosing spondylitis of multiple sites in spine
M45.1 Ankylosing spondylitis of occipito-atlanto-axial region
M45.2 Ankylosing spondylitis of cervical region
M45.3 Ankylosing spondylitis of cervicothoracic region
M45.4 Ankylosing spondylitis of thoracic region
M45.5 Ankylosing spondylitis of thoracolumbar region
M45.6 Ankylosing spondylitis lumbar region
M45.7 Ankylosing spondylitis of lumbosacral region
M45.8 Ankylosing spondylitis sacral and sacrococcygeal region
M45.9 Ankylosing spondylitis of unspecified sites in spine

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.