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ICD-10-CM Codes
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M00-M99
Diseases of the musculoskeletal system and connective tissue
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M45-M49
Spondylopathies
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M45-
Ankylosing spondylitis
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2022 ICD-10-CM Diagnosis Code M45
2022 ICD-10-CM Diagnosis Code M45
Ankylosing spondylitis
2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
- M45 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
- The 2022 edition of ICD-10-CM M45 became effective on October 1, 2021.
- This is the American ICD-10-CM version of M45 - other international versions of ICD-10 M45 may differ.
Applicable To- Rheumatoid arthritis of spine
Type 1 ExcludesType 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as M45. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Type 2 ExcludesType 2 Excludes Help
A type 2 excludes note represents "not included here". A type 2 excludes note indicates that the condition excluded is not part of the condition it is excluded from but a patient may have both conditions at the same time. When a type 2 excludes note appears under a code it is acceptable to use both the code (M45) and the excluded code together.
The following code(s) above
M45 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
- Applicable To annotations, or
- Code Also annotations, or
- Code First annotations, or
- Excludes1 annotations, or
- Excludes2 annotations, or
- Includes annotations, or
- Note annotations, or
- Use Additional annotations
that may be applicable to
M45:
- A chronic inflammatory condition affecting the axial joints, such as the sacroiliac joint and other intervertebral or costovertebral joints. It occurs predominantly in young males and is characterized by pain and stiffness of joints (ankylosis) with inflammation at tendon insertions.
- An autoimmune chronic inflammatory disorder characterized by inflammation in the vertebral joints of the spine and sacroiliac joints. It predominantly affects young males. Patients present with stiffness and pain in the spine.
- Ankylosing spondylitis is a type of arthritis of the spine. It causes swelling between your vertebrae, which are the disks that make up your spine, and in the joints between your spine and pelvis. Ankylosing spondylitis is an immune disease. The disease is more common and more severe in men. It often runs in families. Early symptoms include back pain and stiffness. These problems often start in late adolescence or early adulthood. Over time, ankylosing spondylitis can fuse your vertebrae together, limiting movement. Symptoms can worsen or improve or stop altogether. The disease has no cure, but medicines can relieve the pain, swelling and other symptoms. Exercise can also help. nih: national institute of arthritis and musculoskeletal and skin disease
- Chronic inflammation of the spine and the low back bone joint
Code History
- 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
- 2017 (effective 10/1/2016): No change
- 2018 (effective 10/1/2017): No change
- 2019 (effective 10/1/2018): No change
- 2020 (effective 10/1/2019): No change
- 2021 (effective 10/1/2020): No change
- 2022 (effective 10/1/2021): No change
Code annotations containing back-references to M45:
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Code First: J99
ICD-10-CM Diagnosis Code J99
Respiratory disorders in diseases classified elsewhere
2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code Manifestation Code
Code First- underlying disease, such as:
- amyloidosis (E85.-)
- ankylosing spondylitis (M45)
- congenital syphilis (A50.5)
- cryoglobulinemia (D89.1)
- early congenital syphilis (A50.0)
- plasminogen deficiency (E88.02)
- schistosomiasis (B65.0-B65.9)
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Type 1 Excludes: M05, G55
ICD-10-CM Diagnosis Code M05
Rheumatoid arthritis with rheumatoid factor
2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
Type 1 Excludes- rheumatic fever (I00)
- juvenile rheumatoid arthritis (M08.-)
- rheumatoid arthritis of spine (M45.-)
ICD-10-CM Diagnosis Code G55
Nerve root and plexus compressions in diseases classified elsewhere
2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code Manifestation Code
Code First- underlying disease, such as:
- neoplasm (C00-D49)
Type 1 Excludes- nerve root compression (due to) (in) ankylosing spondylitis (M45.-)
- nerve root compression (due to) (in) dorsopathies (M53.-, M54.-)
- nerve root compression (due to) (in) intervertebral disc disorders (M50.1.-, M51.1.-)
- nerve root compression (due to) (in) spondylopathies (M46.-, M48.-)
- nerve root compression (due to) (in) spondylosis (M47.0-, M47.2.-)
ICD-10-CM Codes Adjacent To M45
M43.8X1 …… occipito-atlanto-axial region
M43.8X8 …… sacral and sacrococcygeal region
M43.9 Deforming dorsopathy, unspecified
M45
Ankylosing spondylitis
M45.0 Ankylosing spondylitis of multiple sites in spine
M45.1 Ankylosing spondylitis of occipito-atlanto-axial region
M45.2 Ankylosing spondylitis of cervical region
M45.3 Ankylosing spondylitis of cervicothoracic region
M45.4 Ankylosing spondylitis of thoracic region
M45.5 Ankylosing spondylitis of thoracolumbar region
M45.6 Ankylosing spondylitis lumbar region
M45.7 Ankylosing spondylitis of lumbosacral region
M45.8 Ankylosing spondylitis sacral and sacrococcygeal region
M45.9 Ankylosing spondylitis of unspecified sites in spine
Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.
