ICD-10-CM Codes
N00-N99
N10-N16
N16-
2023 ICD-10-CM Diagnosis Code N16

2023 ICD-10-CM Diagnosis Code N16

Renal tubulo-interstitial disorders in diseases classified elsewhere

2016

2017

2018

2019

2020

2021

2022

2023

Billable/Specific Code

Manifestation Code

N16 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
Short description: Renal tubulo-interstitial disord in diseases classd elswhr
The 2023 edition of ICD-10-CM N16 became effective on October 1, 2022.
This is the American ICD-10-CM version of N16 - other international versions of ICD-10 N16 may differ.

ICD-10-CM Coding Rules

N16 describes the manifestation of an underlying disease, not the disease itself.

Applicable To

Pyelonephritis
Tubulo-interstitial nephritis

Code First

Code First Help

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.

underlying disease, such as:
brucellosis (
ICD-10-CM Diagnosis Code A23.0
Brucellosis due to Brucella melitensis
A23.0-
ICD-10-CM Diagnosis Code A23.9
Brucellosis, unspecified
A23.9
)
cryoglobulinemia (
ICD-10-CM Diagnosis Code D89.1
Cryoglobulinemia
Applicable To
- Cryoglobulinemic purpura
- Cryoglobulinemic vasculitis
- Essential cryoglobulinemia
- Idiopathic cryoglobulinemia
- Mixed cryoglobulinemia
- Primary cryoglobulinemia
- Secondary cryoglobulinemia
D89.1
)
glycogen storage disease (
ICD-10-CM Diagnosis Code E74.0
Glycogen storage disease
E74.0
)
leukemia (
ICD-10-CM Diagnosis Code C91
Lymphoid leukemia
Type 1 Excludes
- personal history of leukemia (Z85.6)
C91
-
ICD-10-CM Diagnosis Code C95
Leukemia of unspecified cell type
Type 1 Excludes
- personal history of leukemia (Z85.6)
C95
)
lymphoma (
ICD-10-CM Diagnosis Code C81.0
Nodular lymphocyte predominant Hodgkin lymphoma
C81.0-
ICD-10-CM Diagnosis Code C85.9
Non-Hodgkin lymphoma, unspecified
Applicable To
- Lymphoma NOS
- Malignant lymphoma NOS
- Non-Hodgkin lymphoma NOS
C85.9
,
ICD-10-CM Diagnosis Code C96.0
Multifocal and multisystemic (disseminated) Langerhans-cell histiocytosis
Applicable To
- Histiocytosis X, multisystemic
- Letterer-Siwe disease
Type 1 Excludes
- adult pulmonary Langerhans cell histiocytosis (J84.82)
- multifocal and unisystemic Langerhans-cell histiocytosis (C96.5)
- unifocal Langerhans-cell histiocytosis (C96.6)
C96.0-
ICD-10-CM Diagnosis Code C96.9
Malignant neoplasm of lymphoid, hematopoietic and related tissue, unspecified
C96.9
)
multiple myeloma (
ICD-10-CM Diagnosis Code C90.0
Multiple myeloma
Applicable To
- Kahler's disease
- Medullary plasmacytoma
- Myelomatosis
- Plasma cell myeloma
Type 1 Excludes
- solitary myeloma (C90.3-)
- solitary plasmactyoma (C90.3-)
C90.0-
)
sepsis (
ICD-10-CM Diagnosis Code A40.0
Sepsis due to streptococcus, group A
A40.0-
ICD-10-CM Diagnosis Code A41.9
Sepsis, unspecified organism
Applicable To
- Septicemia NOS
A41.9
)
Wilson's disease (
ICD-10-CM Diagnosis Code E83.0
Disorders of copper metabolism
E83.0
)

Type 1 Excludes

Type 1 Excludes Help

A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as N16. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.

diphtheritic pyelonephritis and tubulo-interstitial nephritis (
ICD-10-CM Diagnosis Code A36.84
Diphtheritic tubulo-interstitial nephropathy
A36.84
)
pyelonephritis and tubulo-interstitial nephritis in candidiasis (
ICD-10-CM Diagnosis Code B37.49
Other urogenital candidiasis
Applicable To
- Candidal pyelonephritis
B37.49
)
pyelonephritis and tubulo-interstitial nephritis in cystinosis (
ICD-10-CM Diagnosis Code E72.04
Cystinosis
Applicable To
- Fanconi (-de Toni) (-Debré) syndrome with cystinosis
Type 1 Excludes
- Fanconi (-de Toni) (-Debré) syndrome without cystinosis (E72.09)
E72.04
)
pyelonephritis and tubulo-interstitial nephritis in salmonella infection (
ICD-10-CM Diagnosis Code A02.25
Salmonella pyelonephritis
Applicable To
- Salmonella tubulo-interstitial nephropathy
A02.25
)
pyelonephritis and tubulo-interstitial nephritis in sarcoidosis (
ICD-10-CM Diagnosis Code D86.84
Sarcoid pyelonephritis
Applicable To
- Tubulo-interstitial nephropathy in sarcoidosis
D86.84
)
pyelonephritis and tubulo-interstitial nephritis in Sjogren syndrome (
ICD-10-CM Diagnosis Code M35.04
Sjögren syndrome with tubulo-interstitial nephropathy
Applicable To
- Renal tubular acidosis in sicca syndrome
M35.04
)
pyelonephritis and tubulo-interstitial nephritis in systemic lupus erythematosus (
ICD-10-CM Diagnosis Code M32.15
Tubulo-interstitial nephropathy in systemic lupus erythematosus
M32.15
)
pyelonephritis and tubulo-interstitial nephritis in toxoplasmosis (
ICD-10-CM Diagnosis Code B58.83
Toxoplasma tubulo-interstitial nephropathy
Applicable To
- Toxoplasma pyelonephritis
B58.83
)
renal tubular degeneration in diabetes (E08-E13
ICD-10-CM Range E08-E13
Diabetes mellitus
- E08 Diabetes mellitus due to underlying cond...
- E09 Drug or chemical induced diabetes mellit...
- E10 Type 1 diabetes mellitus
- E11 Type 2 diabetes mellitus
- E13 Other specified diabetes mellitus
with .29)
syphilitic pyelonephritis and tubulo-interstitial nephritis (
ICD-10-CM Diagnosis Code A52.75
Syphilis of kidney and ureter
Applicable To
- Syphilitic glomerular disease
A52.75
)

The following code(s) above N16 contain annotation back-references

Annotation Back-References

In this context, annotation back-references refer to codes that contain:

Applicable To annotations, or
Code Also annotations, or
Code First annotations, or
Excludes1 annotations, or
Excludes2 annotations, or
Includes annotations, or
Note annotations, or
Use Additional annotations

that may be applicable to N16:

N00-N99
2023 ICD-10-CM Range N00-N99
Diseases of the genitourinary system
Type 2 Excludes
- certain conditions originating in the perinatal period (P04-P96)
- certain infectious and parasitic diseases (A00-B99)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Diseases of the genitourinary system
N10-N16
2023 ICD-10-CM Range N10-N16
Renal tubulo-interstitial diseases
Includes
- pyelonephritis
Type 1 Excludes
- pyeloureteritis cystica (N28.85)
Renal tubulo-interstitial diseases

Approximate Synonyms

Pyelonephritis associated with another disorder
Pyelonephritis, secondary

Clinical Information

A disorder characterized by an infectious process involving the kidney.
An acute or chronic inflammatory process affecting the kidney. It is caused by bacteria and in most cases it is the result of a urinary tract infection. Signs and symptoms include fever, chills, flank pain, painful and frequent urination, cloudy or bloody urine, and confusion.
Inflammation of the kidney and its pelvis due to infection.
Inflammation of the kidney involving the renal parenchyma (the nephrons); kidney pelvis; and kidney calices. It is characterized by abdominal pain; fever; nausea; vomiting; and occasionally diarrhea.

ICD-10-CM N16 is grouped within Diagnostic Related Group(s) (MS-DRG v40.0):

698 Other kidney and urinary tract diagnoses with mcc
699 Other kidney and urinary tract diagnoses with cc
700 Other kidney and urinary tract diagnoses without cc/mcc

Convert N16 to ICD-9-CM

Code History

2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
2017 (effective 10/1/2016): No change
2018 (effective 10/1/2017): No change
2019 (effective 10/1/2018): No change
2020 (effective 10/1/2019): No change
2021 (effective 10/1/2020): No change
2022 (effective 10/1/2021): No change
2023 (effective 10/1/2022): No change

Code annotations containing back-references to N16:

Type 1 Excludes: N08
, N08

ICD-10-CM Diagnosis Code N08
Glomerular disorders in diseases classified elsewhere
Applicable To
- Glomerulonephritis
- Nephritis
- Nephropathy
Code First
- underlying disease, such as:
- amyloidosis (E85.-)
- congenital syphilis (A50.5)
- cryoglobulinemia (D89.1)
- disseminated intravascular coagulation (D65)
- gout (M1A.-, M10.-)
- microscopic polyangiitis (M31.7)
- multiple myeloma (C90.0-)
- sepsis (A40.0-A41.9)
- sickle-cell disease (D57.0-D57.8)
Type 1 Excludes
- glomerulonephritis, nephritis and nephropathy (in):
- antiglomerular basement membrane disease (M31.0)
- diabetes (E08-E13 with .21)
- gonococcal (A54.21)
- Goodpasture's syndrome (M31.0)
- hemolytic-uremic syndrome (D59.3-)
- lupus (M32.14)
- mumps (B26.83)
- syphilis (A52.75)
- systemic lupus erythematosus (M32.14)
- Wegener's granulomatosis (M31.31)
- pyelonephritis in diseases classified elsewhere (N16)
- renal tubulo-interstitial disorders classified elsewhere (N16)
ICD-10-CM Diagnosis Code N08
Glomerular disorders in diseases classified elsewhere
Applicable To
- Glomerulonephritis
- Nephritis
- Nephropathy
Code First
- underlying disease, such as:
- amyloidosis (E85.-)
- congenital syphilis (A50.5)
- cryoglobulinemia (D89.1)
- disseminated intravascular coagulation (D65)
- gout (M1A.-, M10.-)
- microscopic polyangiitis (M31.7)
- multiple myeloma (C90.0-)
- sepsis (A40.0-A41.9)
- sickle-cell disease (D57.0-D57.8)
Type 1 Excludes
- glomerulonephritis, nephritis and nephropathy (in):
- antiglomerular basement membrane disease (M31.0)
- diabetes (E08-E13 with .21)
- gonococcal (A54.21)
- Goodpasture's syndrome (M31.0)
- hemolytic-uremic syndrome (D59.3-)
- lupus (M32.14)
- mumps (B26.83)
- syphilis (A52.75)
- systemic lupus erythematosus (M32.14)
- Wegener's granulomatosis (M31.31)
- pyelonephritis in diseases classified elsewhere (N16)
- renal tubulo-interstitial disorders classified elsewhere (N16)

ICD-10-CM Codes Adjacent To N16

N14.11 Contrast-induced nephropathy

N14.19 Nephropathy induced by other drugs, medicaments and biological substances

N14.2 Nephropathy induced by unspecified drug, medicament or biological substance

N14.3 Nephropathy induced by heavy metals

N14.4 Toxic nephropathy, not elsewhere classified

N15 Other renal tubulo-interstitial diseases

N15.0 Balkan nephropathy

N15.1 Renal and perinephric abscess

N15.8 Other specified renal tubulo-interstitial diseases

N15.9 Renal tubulo-interstitial disease, unspecified

N16 Renal tubulo-interstitial disorders in diseases classified elsewhere

N17 Acute kidney failure

N17.0 Acute kidney failure with tubular necrosis

N17.1 Acute kidney failure with acute cortical necrosis

N17.2 Acute kidney failure with medullary necrosis

N17.8 Other acute kidney failure

N17.9 Acute kidney failure, unspecified

N18 Chronic kidney disease (CKD)

N18.1 Chronic kidney disease, stage 1

N18.2 Chronic kidney disease, stage 2 (mild)

N18.3 Chronic kidney disease, stage 3 (moderate)

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

2023 ICD-10-CM Diagnosis Code N16

Renal tubulo-interstitial disorders in diseases classified elsewhere

Brucellosis due to Brucella melitensis

Brucellosis, unspecified

Cryoglobulinemia

Glycogen storage disease

Lymphoid leukemia

Leukemia of unspecified cell type

Nodular lymphocyte predominant Hodgkin lymphoma

Non-Hodgkin lymphoma, unspecified

Multifocal and multisystemic (disseminated) Langerhans-cell histiocytosis

Malignant neoplasm of lymphoid, hematopoietic and related tissue, unspecified

Multiple myeloma

Sepsis due to streptococcus, group A

Sepsis, unspecified organism

Disorders of copper metabolism

Diphtheritic tubulo-interstitial nephropathy

Other urogenital candidiasis

Cystinosis

Salmonella pyelonephritis

Sarcoid pyelonephritis

Sjögren syndrome with tubulo-interstitial nephropathy

Tubulo-interstitial nephropathy in systemic lupus erythematosus

Toxoplasma tubulo-interstitial nephropathy

Diabetes mellitus

Syphilis of kidney and ureter

Diseases of the genitourinary system

Renal tubulo-interstitial diseases

Glomerular disorders in diseases classified elsewhere

Glomerular disorders in diseases classified elsewhere