ICD-10-CM Codes
O00-O9A Pregnancy, childbirth and the puerperium
O20-O29 Other maternal disorders predominantly related to pregnancy
O21- Excessive vomiting in pregnancy
2022 ICD-10-CM Diagnosis Code O21.1

2022 ICD-10-CM Diagnosis Code O21.1

Hyperemesis gravidarum with metabolic disturbance

2016

2017

2018

2019

2020

2021

2022

Billable/Specific Code

Maternity Dx (12-55 years)

O21.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
The 2022 edition of ICD-10-CM O21.1 became effective on October 1, 2021.
This is the American ICD-10-CM version of O21.1 - other international versions of ICD-10 O21.1 may differ.

ICD-10-CM Coding Rules

O21.1 is applicable to maternity patients aged 12 - 55 years inclusive.

Applicable To

Hyperemesis gravidarum, starting before the end of the 20th week of gestation, with metabolic disturbance such as carbohydrate depletion
Hyperemesis gravidarum, starting before the end of the 20th week of gestation, with metabolic disturbance such as dehydration
Hyperemesis gravidarum, starting before the end of the 20th week of gestation, with metabolic disturbance such as electrolyte imbalance

The following code(s) above O21.1 contain annotation back-references

Annotation Back-References

In this context, annotation back-references refer to codes that contain:

Applicable To annotations, or
Code Also annotations, or
Code First annotations, or
Excludes1 annotations, or
Excludes2 annotations, or
Includes annotations, or
Note annotations, or
Use Additional annotations

that may be applicable to O21.1:

O00-O9A
2022 ICD-10-CM Range O00-O9A
Pregnancy, childbirth and the puerperium
Note
- CODES FROM THIS CHAPTER ARE FOR USE ONLY ON MATERNAL RECORDS, NEVER ON NEWBORN RECORDS
- Codes from this chapter are for use for conditions related to or aggravated by the pregnancy, childbirth, or by the puerperium (maternal causes or obstetric causes)
- Trimesters are counted from the first day of the last menstrual period. They are defined as follows:
- 1st trimester- less than 14 weeks 0 days
- 2nd trimester- 14 weeks 0 days to less than 28 weeks 0 days
- 3rd trimester- 28 weeks 0 days until delivery
Type 1 Excludes
- supervision of normal pregnancy (Z34.-)
Type 2 Excludes
- mental and behavioral disorders associated with the puerperium (F53.-)
- obstetrical tetanus (A34)
- postpartum necrosis of pituitary gland (E23.0)
- puerperal osteomalacia (M83.0)
Use Additional
- code from category Z3A, Weeks of gestation, to identify the specific week of the pregnancy, if known.
Pregnancy, childbirth and the puerperium
O20-O29
2022 ICD-10-CM Range O20-O29
Other maternal disorders predominantly related to pregnancy
Type 2 Excludes
- maternal care related to the fetus and amniotic cavity and possible delivery problems (O30-O48)
- maternal diseases classifiable elsewhere but complicating pregnancy, labor and delivery, and the puerperium (O98-O99)
Other maternal disorders predominantly related to pregnancy

Approximate Synonyms

Hyperemesis gravidarum (excessive vomiting in pregnancy), severe
Hyperemesis gravidarum (severe vomiting in pregnancy) with metabolic disturbance
Severe hyperemesis gravidarum

ICD-10-CM O21.1 is grouped within Diagnostic Related Group(s) (MS-DRG v39.0):

817 Other antepartum diagnoses with o.r. Procedures with mcc
818 Other antepartum diagnoses with o.r. Procedures with cc
819 Other antepartum diagnoses with o.r. Procedures without cc/mcc
831 Other antepartum diagnoses without o.r. Procedures with mcc
832 Other antepartum diagnoses without o.r. Procedures with cc
833 Other antepartum diagnoses without o.r. Procedures without cc/mcc

Convert O21.1 to ICD-9-CM

Code History

2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
2017 (effective 10/1/2016): No change
2018 (effective 10/1/2017): No change
2019 (effective 10/1/2018): No change
2020 (effective 10/1/2019): No change
2021 (effective 10/1/2020): No change
2022 (effective 10/1/2021): No change

Code annotations containing back-references to O21.1:

Type 1 Excludes: E87

ICD-10-CM Diagnosis Code E87
Other disorders of fluid, electrolyte and acid-base balance
Type 1 Excludes
- diabetes insipidus (E23.2)
- electrolyte imbalance associated with hyperemesis gravidarum (O21.1)
- electrolyte imbalance following ectopic or molar pregnancy (O08.5)
- familial periodic paralysis (G72.3)

Diagnosis Index entries containing back-references to O21.1:

Hyperemesis R11.10
ICD-10-CM Diagnosis Code R11.10
Vomiting, unspecified
Applicable To
Vomiting NOS
- gravidarum (mild) O21.0
  ICD-10-CM Diagnosis Code O21.0
  Mild hyperemesis gravidarum
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code Maternity Dx (12-55 years)
  Applicable To
  Hyperemesis gravidarum, mild or unspecified, starting before the end of the 20th week of gestation
  - with
    - carbohydrate depletion O21.1
    - dehydration O21.1
    - electrolyte imbalance O21.1
    - metabolic disturbance O21.1
  - severe O21.1 (with metabolic disturbance)
Imbalance R26.89
ICD-10-CM Diagnosis Code R26.89
Other abnormalities of gait and mobility
- electrolyte E87.8
  ICD-10-CM Diagnosis Code E87.8
  Other disorders of electrolyte and fluid balance, not elsewhere classified
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  Applicable To
  Electrolyte imbalance NOS
  Hyperchloremia
  Hypochloremia
  - due to hyperemesis gravidarum O21.1

ICD-10-CM Codes Adjacent To O21.1

O16.3 Unspecified maternal hypertension, third trimester

O16.4 Unspecified maternal hypertension, complicating childbirth

O16.5 Unspecified maternal hypertension, complicating the puerperium

O16.9 Unspecified maternal hypertension, unspecified trimester

O20 Hemorrhage in early pregnancy

O20.0 Threatened abortion

O20.8 Other hemorrhage in early pregnancy

O20.9 Hemorrhage in early pregnancy, unspecified

O21 Excessive vomiting in pregnancy

O21.0 Mild hyperemesis gravidarum

O21.1 Hyperemesis gravidarum with metabolic disturbance

O21.2 Late vomiting of pregnancy

O21.8 Other vomiting complicating pregnancy

O21.9 Vomiting of pregnancy, unspecified

O22 Venous complications and hemorrhoids in pregnancy

O22.0 Varicose veins of lower extremity in pregnancy

O22.00 …… unspecified trimester

O22.01 …… first trimester

O22.02 …… second trimester

O22.03 …… third trimester

O22.1 Genital varices in pregnancy

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

2022 ICD-10-CM Diagnosis Code O21.1

Hyperemesis gravidarum with metabolic disturbance

Pregnancy, childbirth and the puerperium

Other maternal disorders predominantly related to pregnancy

Other disorders of fluid, electrolyte and acid-base balance

Vomiting, unspecified

Mild hyperemesis gravidarum

Other abnormalities of gait and mobility

Other disorders of electrolyte and fluid balance, not elsewhere classified