ICD-10-CM Codes
R00-R99
R50-R69
R53-
2023 ICD-10-CM Diagnosis Code R53.0

2023 ICD-10-CM Diagnosis Code R53.0

Neoplastic (malignant) related fatigue

2016

2017

2018

2019

2020

2021

2022

2023

Billable/Specific Code

R53.0 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
The 2023 edition of ICD-10-CM R53.0 became effective on October 1, 2022.
This is the American ICD-10-CM version of R53.0 - other international versions of ICD-10 R53.0 may differ.

Code First

Code First Help

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.

associated neoplasm

The following code(s) above R53.0 contain annotation back-references

Annotation Back-References

In this context, annotation back-references refer to codes that contain:

Applicable To annotations, or
Code Also annotations, or
Code First annotations, or
Excludes1 annotations, or
Excludes2 annotations, or
Includes annotations, or
Note annotations, or
Use Additional annotations

that may be applicable to R53.0:

R00-R99
2023 ICD-10-CM Range R00-R99
Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
Note
- This chapter includes symptoms, signs, abnormal results of clinical or other investigative procedures, and ill-defined conditions regarding which no diagnosis classifiable elsewhere is recorded.
- Signs and symptoms that point rather definitely to a given diagnosis have been assigned to a category in other chapters of the classification. In general, categories in this chapter include the less well-defined conditions and symptoms that, without the necessary study of the case to establish a final diagnosis, point perhaps equally to two or more diseases or to two or more systems of the body. Practically all categories in the chapter could be designated 'not otherwise specified', 'unknown etiology' or 'transient'. The Alphabetical Index should be consulted to determine which symptoms and signs are to be allocated here and which to other chapters. The residual subcategories, numbered .8, are generally provided for other relevant symptoms that cannot be allocated elsewhere in the classification.
- The conditions and signs or symptoms included in categories R00-R94 consist of:
- (a) cases for which no more specific diagnosis can be made even after all the facts bearing on the case have been investigated;
- (b) signs or symptoms existing at the time of initial encounter that proved to be transient and whose causes could not be determined;
- (c) provisional diagnosis in a patient who failed to return for further investigation or care;
- (d) cases referred elsewhere for investigation or treatment before the diagnosis was made;
- (e) cases in which a more precise diagnosis was not available for any other reason;
- (f) certain symptoms, for which supplementary information is provided, that represent important problems in medical care in their own right.
Type 2 Excludes
- abnormal findings on antenatal screening of mother (O28.-)
- certain conditions originating in the perinatal period (P04-P96)
- signs and symptoms classified in the body system chapters
- signs and symptoms of breast (N63, N64.5)
Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified

Approximate Synonyms

Cancer related fatigue
Fatigue due to malignant neoplastic disease

ICD-10-CM R53.0 is grouped within Diagnostic Related Group(s) (MS-DRG v40.0):

947 Signs and symptoms with mcc
948 Signs and symptoms without mcc

Convert R53.0 to ICD-9-CM

Code History

2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
2017 (effective 10/1/2016): No change
2018 (effective 10/1/2017): No change
2019 (effective 10/1/2018): No change
2020 (effective 10/1/2019): No change
2021 (effective 10/1/2020): No change
2022 (effective 10/1/2021): No change
2023 (effective 10/1/2022): No change

Diagnosis Index entries containing back-references to R53.0:

Fatigue R53.83
ICD-10-CM Diagnosis Code R53.83
Other fatigue
Applicable To
Fatigue NOS
Lack of energy
Lethargy
Tiredness
Type 2 Excludes
exhaustion and fatigue due to depressive episode (F32.-)
- neoplasm-related R53.0

ICD-10-CM Codes Adjacent To R53.0

R50.81 Fever presenting with conditions classified elsewhere

R50.82 Postprocedural fever

R50.83 Postvaccination fever

R50.84 Febrile nonhemolytic transfusion reaction

R50.9 Fever, unspecified

R51 Headache

R51.0 Headache with orthostatic component, not elsewhere classified

R51.9 Headache, unspecified

R52 Pain, unspecified

R53 Malaise and fatigue

R53.0 Neoplastic (malignant) related fatigue

R53.1 Weakness

R53.2 Functional quadriplegia

R53.8 Other malaise and fatigue

R53.81 Other malaise

R53.82 Chronic fatigue, unspecified

R53.83 Other fatigue

R54 Age-related physical debility

R55 Syncope and collapse

R56 Convulsions, not elsewhere classified

R56.0 Febrile convulsions

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

2023 ICD-10-CM Diagnosis Code R53.0

Neoplastic (malignant) related fatigue

Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified

Other fatigue