ICD-10-CM Codes
R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
R50-R69 General symptoms and signs
R53- Malaise and fatigue
2022 ICD-10-CM Diagnosis Code R53.8

2022 ICD-10-CM Diagnosis Code R53.8

Other malaise and fatigue

2016

2017

2018

2019

2020

2021

2022

Non-Billable/Non-Specific Code

R53.8 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
The 2022 edition of ICD-10-CM R53.8 became effective on October 1, 2021.
This is the American ICD-10-CM version of R53.8 - other international versions of ICD-10 R53.8 may differ.

Type 1 Excludes

Type 1 Excludes Help

A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as R53.8. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.

combat exhaustion and fatigue (
ICD-10-CM Diagnosis Code F43.0
Acute stress reaction
Applicable To
- Acute crisis reaction
- Acute reaction to stress
- Combat and operational stress reaction
- Combat fatigue
- Crisis state
- Psychic shock
F43.0
)
congenital debility (
ICD-10-CM Diagnosis Code P96.9
Condition originating in the perinatal period, unspecified
Applicable To
- Congenital debility NOS
P96.9
)
exhaustion and fatigue due to excessive exertion (
ICD-10-CM Diagnosis Code T73.3
Exhaustion due to excessive exertion
Applicable To
- Exhaustion due to overexertion
T73.3
)
exhaustion and fatigue due to exposure (
ICD-10-CM Diagnosis Code T73.2
Exhaustion due to exposure
T73.2
)
exhaustion and fatigue due to heat (
ICD-10-CM Diagnosis Code T67
- T67 Effects of heat and light
  - T67.0 Heatstroke and sunstroke
    - T67.01 Heatstroke and sunstroke
      T67.01XA …… initial encounter
      T67.01XD Heatstroke and sunstroke, subsequent encounte...
      T67.01XS …… sequela
    - T67.02 Exertional heatstroke
      T67.02XA …… initial encounter
      T67.02XD …… subsequent encounter
      T67.02XS …… sequela
    - T67.09 Other heatstroke and sunstroke
      T67.09XA Other heatstroke and sunstroke, initial encou...
      T67.09XD Other heatstroke and sunstroke, subsequent en...
      T67.09XS …… sequela
  - T67.1 Heat syncope
    - T67.1XXA …… initial encounter
    - T67.1XXD …… subsequent encounter
    - T67.1XXS …… sequela
  - T67.2 Heat cramp
    - T67.2XXA …… initial encounter
    - T67.2XXD …… subsequent encounter
    - T67.2XXS …… sequela
  - T67.3 Heat exhaustion, anhydrotic
    - T67.3XXA Heat exhaustion, anhydrotic, initial encounte...
    - T67.3XXD Heat exhaustion, anhydrotic, subsequent encou...
    - T67.3XXS …… sequela
  - T67.4 Heat exhaustion due to salt depletion
    - T67.4XXA Heat exhaustion due to salt depletion, initia...
    - T67.4XXD Heat exhaustion due to salt depletion, subseq...
    - T67.4XXS Heat exhaustion due to salt depletion, sequel...
  - T67.5 Heat exhaustion, unspecified
    - T67.5XXA Heat exhaustion, unspecified, initial encount...
    - T67.5XXD Heat exhaustion, unspecified, subsequent enco...
    - T67.5XXS …… sequela
  - T67.6 Heat fatigue, transient
    - T67.6XXA …… initial encounter
    - T67.6XXD Heat fatigue, transient, subsequent encounter...
    - T67.6XXS …… sequela
  - T67.7 Heat edema
    - T67.7XXA …… initial encounter
    - T67.7XXD …… subsequent encounter
    - T67.7XXS …… sequela
  - T67.8 Other effects of heat and light
    - T67.8XXA Other effects of heat and light, initial enco...
    - T67.8XXD Other effects of heat and light, subsequent e...
    - T67.8XXS …… sequela
  - T67.9 Effect of heat and light, unspecified
    - T67.9XXA Effect of heat and light, unspecified, initia...
    - T67.9XXD Effect of heat and light, unspecified, subseq...
    - T67.9XXS Effect of heat and light, unspecified, sequel...
T67.-
)
exhaustion and fatigue due to pregnancy (
ICD-10-CM Diagnosis Code O26.8
Other specified pregnancy related conditions
O26.8-
)
exhaustion and fatigue due to recurrent depressive episode (
ICD-10-CM Diagnosis Code F33
Major depressive disorder, recurrent
Includes
- recurrent episodes of depressive reaction
- recurrent episodes of endogenous depression
- recurrent episodes of major depression
- recurrent episodes of psychogenic depression
- recurrent episodes of reactive depression
- recurrent episodes of seasonal depressive disorder
- recurrent episodes of vital depression
Type 1 Excludes
- bipolar disorder (F31.-)
- manic episode (F30.-)
F33
)
exhaustion and fatigue due to senile debility (
ICD-10-CM Diagnosis Code R54
Age-related physical debility
Applicable To
- Frailty
- Old age
- Senescence
- Senile asthenia
- Senile debility
Type 1 Excludes
- age-related cognitive decline (R41.81)
- sarcopenia (M62.84)
- senile psychosis (F03)
- senility NOS (R41.81)
R54
)

The following code(s) above R53.8 contain annotation back-references

Annotation Back-References

In this context, annotation back-references refer to codes that contain:

Applicable To annotations, or
Code Also annotations, or
Code First annotations, or
Excludes1 annotations, or
Excludes2 annotations, or
Includes annotations, or
Note annotations, or
Use Additional annotations

that may be applicable to R53.8:

R00-R99
2022 ICD-10-CM Range R00-R99
Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
Note
- This chapter includes symptoms, signs, abnormal results of clinical or other investigative procedures, and ill-defined conditions regarding which no diagnosis classifiable elsewhere is recorded.
- Signs and symptoms that point rather definitely to a given diagnosis have been assigned to a category in other chapters of the classification. In general, categories in this chapter include the less well-defined conditions and symptoms that, without the necessary study of the case to establish a final diagnosis, point perhaps equally to two or more diseases or to two or more systems of the body. Practically all categories in the chapter could be designated 'not otherwise specified', 'unknown etiology' or 'transient'. The Alphabetical Index should be consulted to determine which symptoms and signs are to be allocated here and which to other chapters. The residual subcategories, numbered .8, are generally provided for other relevant symptoms that cannot be allocated elsewhere in the classification.
- The conditions and signs or symptoms included in categories R00-R94 consist of:
- (a) cases for which no more specific diagnosis can be made even after all the facts bearing on the case have been investigated;
- (b) signs or symptoms existing at the time of initial encounter that proved to be transient and whose causes could not be determined;
- (c) provisional diagnosis in a patient who failed to return for further investigation or care;
- (d) cases referred elsewhere for investigation or treatment before the diagnosis was made;
- (e) cases in which a more precise diagnosis was not available for any other reason;
- (f) certain symptoms, for which supplementary information is provided, that represent important problems in medical care in their own right.
Type 2 Excludes
- abnormal findings on antenatal screening of mother (O28.-)
- certain conditions originating in the perinatal period (P04-P96)
- signs and symptoms classified in the body system chapters
- signs and symptoms of breast (N63, N64.5)
Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified

Code History

2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
2017 (effective 10/1/2016): No change
2018 (effective 10/1/2017): No change
2019 (effective 10/1/2018): No change
2020 (effective 10/1/2019): No change
2021 (effective 10/1/2020): No change
2022 (effective 10/1/2021): No change

ICD-10-CM Codes Adjacent To R53.8

R50.84 Febrile nonhemolytic transfusion reaction

R50.9 Fever, unspecified

R51 Headache

R51.0 Headache with orthostatic component, not elsewhere classified

R51.9 Headache, unspecified

R52 Pain, unspecified

R53 Malaise and fatigue

R53.0 Neoplastic (malignant) related fatigue

R53.1 Weakness

R53.2 Functional quadriplegia

R53.8 Other malaise and fatigue

R53.81 Other malaise

R53.82 Chronic fatigue, unspecified

R53.83 Other fatigue

R54 Age-related physical debility

R55 Syncope and collapse

R56 Convulsions, not elsewhere classified

R56.0 Febrile convulsions

R56.00 Simple febrile convulsions

R56.01 Complex febrile convulsions

R56.1 Post traumatic seizures

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

2022 ICD-10-CM Diagnosis Code R53.8

Other malaise and fatigue

Acute stress reaction

Condition originating in the perinatal period, unspecified

Exhaustion due to excessive exertion

Exhaustion due to exposure

Other specified pregnancy related conditions

Major depressive disorder, recurrent

Age-related physical debility

Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified