ICD-10-CM Codes
R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
R50-R69 General symptoms and signs
R65- Symptoms and signs specifically associated with systemic inflammation and infection
2022 ICD-10-CM Diagnosis Code R65

2022 ICD-10-CM Diagnosis Code R65

Symptoms and signs specifically associated with systemic inflammation and infection

2016

2017

2018

2019

2020

2021

2022

Non-Billable/Non-Specific Code

R65 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
Short description: Symp and signs specifically assoc w sys inflam and infct
The 2022 edition of ICD-10-CM R65 became effective on October 1, 2021.
This is the American ICD-10-CM version of R65 - other international versions of ICD-10 R65 may differ.

The following code(s) above R65 contain annotation back-references

Annotation Back-References

In this context, annotation back-references refer to codes that contain:

Applicable To annotations, or
Code Also annotations, or
Code First annotations, or
Excludes1 annotations, or
Excludes2 annotations, or
Includes annotations, or
Note annotations, or
Use Additional annotations

that may be applicable to R65:

R00-R99
2022 ICD-10-CM Range R00-R99
Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
Note
- This chapter includes symptoms, signs, abnormal results of clinical or other investigative procedures, and ill-defined conditions regarding which no diagnosis classifiable elsewhere is recorded.
- Signs and symptoms that point rather definitely to a given diagnosis have been assigned to a category in other chapters of the classification. In general, categories in this chapter include the less well-defined conditions and symptoms that, without the necessary study of the case to establish a final diagnosis, point perhaps equally to two or more diseases or to two or more systems of the body. Practically all categories in the chapter could be designated 'not otherwise specified', 'unknown etiology' or 'transient'. The Alphabetical Index should be consulted to determine which symptoms and signs are to be allocated here and which to other chapters. The residual subcategories, numbered .8, are generally provided for other relevant symptoms that cannot be allocated elsewhere in the classification.
- The conditions and signs or symptoms included in categories R00-R94 consist of:
- (a) cases for which no more specific diagnosis can be made even after all the facts bearing on the case have been investigated;
- (b) signs or symptoms existing at the time of initial encounter that proved to be transient and whose causes could not be determined;
- (c) provisional diagnosis in a patient who failed to return for further investigation or care;
- (d) cases referred elsewhere for investigation or treatment before the diagnosis was made;
- (e) cases in which a more precise diagnosis was not available for any other reason;
- (f) certain symptoms, for which supplementary information is provided, that represent important problems in medical care in their own right.
Type 2 Excludes
- abnormal findings on antenatal screening of mother (O28.-)
- certain conditions originating in the perinatal period (P04-P96)
- signs and symptoms classified in the body system chapters
- signs and symptoms of breast (N63, N64.5)
Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified

Code History

2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
2017 (effective 10/1/2016): No change
2018 (effective 10/1/2017): No change
2019 (effective 10/1/2018): No change
2020 (effective 10/1/2019): No change
2021 (effective 10/1/2020): No change
2022 (effective 10/1/2021): No change

ICD-10-CM Codes Adjacent To R65

R63.3 Feeding difficulties

R63.30 …… unspecified

R63.31 Pediatric feeding disorder, acute

R63.32 Pediatric feeding disorder, chronic

R63.39 Other feeding difficulties

R63.4 Abnormal weight loss

R63.5 Abnormal weight gain

R63.6 Underweight

R63.8 Other symptoms and signs concerning food and fluid intake

R64 Cachexia

R65 Symptoms and signs specifically associated with systemic inflammation and infection

R65.1 Systemic inflammatory response syndrome (SIRS) of non-infectious origin

R65.10 …… without acute organ dysfunction

R65.11 …… with acute organ dysfunction

R65.2 Severe sepsis

R65.20 …… without septic shock

R65.21 …… with septic shock

R68 Other general symptoms and signs

R68.0 Hypothermia, not associated with low environmental temperature

R68.1 Nonspecific symptoms peculiar to infancy

R68.11 Excessive crying of infant (baby)

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

2022 ICD-10-CM Diagnosis Code R65

Symptoms and signs specifically associated with systemic inflammation and infection

Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified