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ICD-10-CM Codes
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2023 ICD-10-CM Diagnosis Code R65.11
2023 ICD-10-CM Diagnosis Code R65.11
Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
- R65.11 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
- Short description: SIRS of non-infectious origin w acute organ dysfunction
- The 2023 edition of ICD-10-CM R65.11 became effective on October 1, 2022.
- This is the American ICD-10-CM version of R65.11 - other international versions of ICD-10 R65.11 may differ.
Use AdditionalUse Additional Help
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
- code to identify specific acute organ dysfunction, such as:
- acute kidney failure (
ICD-10-CM Diagnosis Code N17
- N17 Acute kidney failure
- N17.0 Acute kidney failure with tubular necrosis
- N17.1 Acute kidney failure with acute cortical necr...
- N17.2 Acute kidney failure with medullary necrosis
- N17.8 Other acute kidney failure
- N17.9 Acute kidney failure, unspecified
N17.-) - acute respiratory failure (
ICD-10-CM Diagnosis Code J96.0
Acute respiratory failure
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
J96.0-) - critical illness myopathy (
ICD-10-CM Diagnosis Code G72.81
Critical illness myopathy
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
Applicable To- Acute necrotizing myopathy
- Acute quadriplegic myopathy
- Intensive care (ICU) myopathy
- Myopathy of critical illness
G72.81) - critical illness polyneuropathy (
ICD-10-CM Diagnosis Code G62.81
Critical illness polyneuropathy
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
G62.81) - disseminated intravascular coagulopathy [DIC] (
ICD-10-CM Diagnosis Code D65
Disseminated intravascular coagulation [defibrination syndrome]
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
Applicable To- Afibrinogenemia, acquired
- Consumption coagulopathy
- Diffuse or disseminated intravascular coagulation [DIC]
- Fibrinolytic hemorrhage, acquired
- Fibrinolytic purpura
- Purpura fulminans
Type 1 Excludes- disseminated intravascular coagulation (complicating):
- abortion or ectopic or molar pregnancy (O00-O07, O08.1)
- in newborn (P60)
- pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3)
D65) - encephalopathy (metabolic) (septic) (
ICD-10-CM Diagnosis Code G93.41
Metabolic encephalopathy
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
G93.41) - hepatic failure (
ICD-10-CM Diagnosis Code K72.0
Acute and subacute hepatic failure
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
Applicable To- Acute non-viral hepatitis NOS
K72.0-)
The following code(s) above
R65.11 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
- Applicable To annotations, or
- Code Also annotations, or
- Code First annotations, or
- Excludes1 annotations, or
- Excludes2 annotations, or
- Includes annotations, or
- Note annotations, or
- Use Additional annotations
that may be applicable to
R65.11:
Approximate Synonyms
- Systemic inflammatory response syndrome
- Systemic inflammatory response syndrome associated with organ dysfunction
- Systemic inflammatory response syndrome due to non-infectious process with acute organ failure
ICD-10-CM R65.11 is grouped within Diagnostic Related Group(s) (MS-DRG v40.0):
- 864 Fever and inflammatory conditions
Convert R65.11 to ICD-9-CM
Code History
- 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
- 2017 (effective 10/1/2016): No change
- 2018 (effective 10/1/2017): No change
- 2019 (effective 10/1/2018): No change
- 2020 (effective 10/1/2019): No change
- 2021 (effective 10/1/2020): No change
- 2022 (effective 10/1/2021): No change
- 2023 (effective 10/1/2022): No change
- Syndrome - see also Disease
- systemic inflammatory response (SIRS), of non-infectious origin (without organ dysfunction) R65.10
ICD-10-CM Diagnosis Code R65.10
Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
Applicable To- Systemic inflammatory response syndrome (SIRS) NOS
- with acute organ dysfunction R65.11
- System, systemic - see also condition
- inflammatory response syndrome (SIRS) of non-infectious origin (without organ dysfunction) R65.10
ICD-10-CM Diagnosis Code R65.10
Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
Applicable To- Systemic inflammatory response syndrome (SIRS) NOS
- with acute organ dysfunction R65.11
ICD-10-CM Codes Adjacent To R65.11
R63.32 Pediatric feeding disorder, chronic
R63.39 Other feeding difficulties
R63.4 Abnormal weight loss
R63.5 Abnormal weight gain
R63.8 Other symptoms and signs concerning food and fluid intake
R65 Symptoms and signs specifically associated with systemic inflammation and infection
R65.1 Systemic inflammatory response syndrome (SIRS) of non-infectious origin
R65.10 …… without acute organ dysfunction
R65.11
…… with acute organ dysfunction
R65.20 …… without septic shock
R68 Other general symptoms and signs
R68.0 Hypothermia, not associated with low environmental temperature
R68.1 Nonspecific symptoms peculiar to infancy
R68.11 Excessive crying of infant (baby)
R68.13 Apparent life threatening event in infant (ALTE)
R68.19 Other nonspecific symptoms peculiar to infancy
Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.