2019 ICD-10-CM Diagnosis Code R65.21

Severe sepsis with septic shock

The following code(s) above R65.21 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to R65.21:
  • R00-R99
    2019 ICD-10-CM Range R00-R99

    Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified

    • This chapter includes symptoms, signs, abnormal results of clinical or other investigative procedures, and ill-defined conditions regarding which no diagnosis classifiable elsewhere is recorded.
    • Signs and symptoms that point rather definitely to a given diagnosis have been assigned to a category in other chapters of the classification. In general, categories in this chapter include the less well-defined conditions and symptoms that, without the necessary study of the case to establish a final diagnosis, point perhaps equally to two or more diseases or to two or more systems of the body. Practically all categories in the chapter could be designated 'not otherwise specified', 'unknown etiology' or 'transient'. The Alphabetical Index should be consulted to determine which symptoms and signs are to be allocated here and which to other chapters. The residual subcategories, numbered .8, are generally provided for other relevant symptoms that cannot be allocated elsewhere in the classification.
    • The conditions and signs or symptoms included in categories R00-R94 consist of:
    • (a) cases for which no more specific diagnosis can be made even after all the facts bearing on the case have been investigated;
    • (b) signs or symptoms existing at the time of initial encounter that proved to be transient and whose causes could not be determined;
    • (c) provisional diagnosis in a patient who failed to return for further investigation or care;
    • (d) cases referred elsewhere for investigation or treatment before the diagnosis was made;
    • (e) cases in which a more precise diagnosis was not available for any other reason;
    • (f) certain symptoms, for which supplementary information is provided, that represent important problems in medical care in their own right.
    Type 2 Excludes
    • abnormal findings on antenatal screening of mother (O28.-)
    • certain conditions originating in the perinatal period (P04-P96)
    • signs and symptoms classified in the body system chapters
    • signs and symptoms of breast (N63, N64.5)
    Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
  • R65.2
    ICD-10-CM Diagnosis Code R65.2

    Severe sepsis

      2016 2017 2018 2019 Non-Billable/Non-Specific Code
    Applicable To
    • Infection with associated acute organ dysfunction
    • Sepsis with acute organ dysfunction
    • Sepsis with multiple organ dysfunction
    • Systemic inflammatory response syndrome due to infectious process with acute organ dysfunction
    Code First
    • underlying infection, such as:
    • infection following a procedure (T81.4-)
    • infections following infusion, transfusion and therapeutic injection (T80.2-)
    • puerperal sepsis (O85)
    • sepsis following complete or unspecified spontaneous abortion (O03.87)
    • sepsis following ectopic and molar pregnancy (O08.82)
    • sepsis following incomplete spontaneous abortion (O03.37)
    • sepsis following (induced) termination of pregnancy (O04.87)
    • sepsis NOS (A41.9)
    Use Additional
    • code to identify specific acute organ dysfunction, such as:
    • acute kidney failure (N17.-)
    • acute respiratory failure (J96.0-)
    • critical illness myopathy (G72.81)
    • critical illness polyneuropathy (G62.81)
    • disseminated intravascular coagulopathy [DIC] (D65)
    • encephalopathy (metabolic) (septic) (G93.41)
    • hepatic failure (K72.0-)
    Severe sepsis
Approximate Synonyms ICD-10-CM R65.21 is grouped within Diagnostic Related Group(s) (MS-DRG v36.0):

Convert R65.21 to ICD-9-CM

Code History
Code annotations containing back-references to R65.21:

Diagnosis Index entries containing back-references to R65.21:

ICD-10-CM Codes Adjacent To R65.21
R63.5 Abnormal weight gain
R63.6 Underweight
R63.8 Other symptoms and signs concerning food and fluid intake
R64 Cachexia
R65 Symptoms and signs specifically associated with systemic inflammation and infection
R65.1 Systemic inflammatory response syndrome (SIRS) of non-infectious origin
R65.10 …… without acute organ dysfunction
R65.11 …… with acute organ dysfunction
R65.2 Severe sepsis
R65.20 …… without septic shock
R65.21 …… with septic shock
R68 Other general symptoms and signs
R68.0 Hypothermia, not associated with low environmental temperature
R68.1 Nonspecific symptoms peculiar to infancy
R68.11 Excessive crying of infant (baby)
R68.12 Fussy infant (baby)
R68.13 Apparent life threatening event in infant (ALTE)
R68.19 Other nonspecific symptoms peculiar to infancy
R68.2 Dry mouth, unspecified
R68.3 Clubbing of fingers
R68.8 Other general symptoms and signs

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.