2020 ICD-10-CM Diagnosis Code T45.8

Poisoning by, adverse effect of and underdosing of other primarily systemic and hematological agents

    2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
  • T45.8 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • Short description: Primarily systemic and hematological agents
  • The 2020 edition of ICD-10-CM T45.8 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of T45.8 - other international versions of ICD-10 T45.8 may differ.
Applicable To
  • Poisoning by, adverse effect of and underdosing of liver preparations and other antianemic agents
  • Poisoning by, adverse effect of and underdosing of natural blood and blood products
  • Poisoning by, adverse effect of and underdosing of plasma substitute
Type 2 Excludes
Type 2 Excludes Help
A type 2 excludes note represents "not included here". A type 2 excludes note indicates that the condition excluded is not part of the condition it is excluded from but a patient may have both conditions at the same time. When a type 2 excludes note appears under a code it is acceptable to use both the code (T45.8) and the excluded code together.
  • poisoning by, adverse effect of and underdosing of immunoglobulin (
    ICD-10-CM Diagnosis Code T50.Z1

    Poisoning by, adverse effect of and underdosing of immunoglobulin

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    T50.Z1
    )
  • poisoning by, adverse effect of and underdosing of iron (
    ICD-10-CM Diagnosis Code T45.4

    Poisoning by, adverse effect of and underdosing of iron and its compounds

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    T45.4
    )
  • transfusion reactions (
    ICD-10-CM Diagnosis Code T80
    • T80 Complications following infusion, transfusion...
      • T80.0 Air embolism following infusion, transfusion ...
        • T80.0XXA Air embolism following infusion, transfusion ...
        • T80.0XXD Air embolism following infusion, transfusion ...
        • T80.0XXS Air embolism following infusion, transfusion ...
      • T80.1 Vascular complications following infusion, tr...
        • T80.1XXA Vascular complications following infusion, tr...
        • T80.1XXD Vascular complications following infusion, tr...
        • T80.1XXS Vascular complications following infusion, tr...
      • T80.2 Infections following infusion, transfusion an...
        • T80.21 Infection due to central venous catheter
          • T80.211 Bloodstream infection due to central venous c...
            • T80.211A Bloodstream infection due to central venous c...
            • T80.211D Bloodstream infection due to central venous c...
            • T80.211S Bloodstream infection due to central venous c...
          • T80.212 Local infection due to central venous cathete...
            • T80.212A Local infection due to central venous cathete...
            • T80.212D Local infection due to central venous cathete...
            • T80.212S Local infection due to central venous cathete...
          • T80.218 Other infection due to central venous cathete...
            • T80.218A Other infection due to central venous cathete...
            • T80.218D Other infection due to central venous cathete...
            • T80.218S Other infection due to central venous cathete...
          • T80.219 Unspecified infection due to central venous c...
            • T80.219A Unspecified infection due to central venous c...
            • T80.219D Unspecified infection due to central venous c...
            • T80.219S Unspecified infection due to central venous c...
        • T80.22 Acute infection following transfusion, infusi...
          • T80.22XA Acute infection following transfusion, infusi...
          • T80.22XD Acute infection following transfusion, infusi...
          • T80.22XS Acute infection following transfusion, infusi...
        • T80.29 Infection following other infusion, transfusi...
          • T80.29XA Infection following other infusion, transfusi...
          • T80.29XD Infection following other infusion, transfusi...
          • T80.29XS Infection following other infusion, transfusi...
      • T80.3 ABO incompatibility reaction due to transfusi...
        • T80.30 ABO incompatibility reaction due to transfusi...
          • T80.30XA ABO incompatibility reaction due to transfusi...
          • T80.30XD ABO incompatibility reaction due to transfusi...
          • T80.30XS ABO incompatibility reaction due to transfusi...
        • T80.31 ABO incompatibility with hemolytic transfusio...
          • T80.310 ABO incompatibility with acute hemolytic tran...
            • T80.310A ABO incompatibility with acute hemolytic tran...
            • T80.310D ABO incompatibility with acute hemolytic tran...
            • T80.310S ABO incompatibility with acute hemolytic tran...
          • T80.311 ABO incompatibility with delayed hemolytic tr...
            • T80.311A ABO incompatibility with delayed hemolytic tr...
            • T80.311D ABO incompatibility with delayed hemolytic tr...
            • T80.311S ABO incompatibility with delayed hemolytic tr...
          • T80.319 ABO incompatibility with hemolytic transfusio...
            • T80.319A ABO incompatibility with hemolytic transfusio...
            • T80.319D ABO incompatibility with hemolytic transfusio...
            • T80.319S ABO incompatibility with hemolytic transfusio...
        • T80.39 Other ABO incompatibility reaction due to tra...
          • T80.39XA Other ABO incompatibility reaction due to tra...
          • T80.39XD Other ABO incompatibility reaction due to tra...
          • T80.39XS Other ABO incompatibility reaction due to tra...
      • T80.4 Rh incompatibility reaction due to transfusio...
        • T80.40 Rh incompatibility reaction due to transfusio...
          • T80.40XA Rh incompatibility reaction due to transfusio...
          • T80.40XD Rh incompatibility reaction due to transfusio...
          • T80.40XS Rh incompatibility reaction due to transfusio...
        • T80.41 Rh incompatibility with hemolytic transfusion...
          • T80.410 Rh incompatibility with acute hemolytic trans...
            • T80.410A Rh incompatibility with acute hemolytic trans...
            • T80.410D Rh incompatibility with acute hemolytic trans...
            • T80.410S Rh incompatibility with acute hemolytic trans...
          • T80.411 Rh incompatibility with delayed hemolytic tra...
            • T80.411A Rh incompatibility with delayed hemolytic tra...
            • T80.411D Rh incompatibility with delayed hemolytic tra...
            • T80.411S Rh incompatibility with delayed hemolytic tra...
          • T80.419 Rh incompatibility with hemolytic transfusion...
            • T80.419A Rh incompatibility with hemolytic transfusion...
            • T80.419D Rh incompatibility with hemolytic transfusion...
            • T80.419S Rh incompatibility with hemolytic transfusion...
        • T80.49 Other Rh incompatibility reaction due to tran...
          • T80.49XA Other Rh incompatibility reaction due to tran...
          • T80.49XD Other Rh incompatibility reaction due to tran...
          • T80.49XS Other Rh incompatibility reaction due to tran...
      • T80.A Non-ABO incompatibility reaction due to trans...
        • T80.A0 Non-ABO incompatibility reaction due to trans...
          • T80.A0XA Non-ABO incompatibility reaction due to trans...
          • T80.A0XD Non-ABO incompatibility reaction due to trans...
          • T80.A0XS Non-ABO incompatibility reaction due to trans...
        • T80.A1 Non-ABO incompatibility with hemolytic transf...
          • T80.A10 Non-ABO incompatibility with acute hemolytic ...
            • T80.A10A Non-ABO incompatibility with acute hemolytic ...
            • T80.A10D Non-ABO incompatibility with acute hemolytic ...
            • T80.A10S Non-ABO incompatibility with acute hemolytic ...
          • T80.A11 Non-ABO incompatibility with delayed hemolyti...
            • T80.A11A Non-ABO incompatibility with delayed hemolyti...
            • T80.A11D Non-ABO incompatibility with delayed hemolyti...
            • T80.A11S Non-ABO incompatibility with delayed hemolyti...
          • T80.A19 Non-ABO incompatibility with hemolytic transf...
            • T80.A19A Non-ABO incompatibility with hemolytic transf...
            • T80.A19D Non-ABO incompatibility with hemolytic transf...
            • T80.A19S Non-ABO incompatibility with hemolytic transf...
        • T80.A9 Other non-ABO incompatibility reaction due to...
          • T80.A9XA Other non-ABO incompatibility reaction due to...
          • T80.A9XD Other non-ABO incompatibility reaction due to...
          • T80.A9XS Other non-ABO incompatibility reaction due to...
      • T80.5 Anaphylactic reaction due to serum
        • T80.51 Anaphylactic reaction due to administration o...
          • T80.51XA Anaphylactic reaction due to administration o...
          • T80.51XD Anaphylactic reaction due to administration o...
          • T80.51XS Anaphylactic reaction due to administration o...
        • T80.52 Anaphylactic reaction due to vaccination
          • T80.52XA Anaphylactic reaction due to vaccination, ini...
          • T80.52XD Anaphylactic reaction due to vaccination, sub...
          • T80.52XS Anaphylactic reaction due to vaccination, seq...
        • T80.59 Anaphylactic reaction due to other serum
          • T80.59XA Anaphylactic reaction due to other serum, ini...
          • T80.59XD Anaphylactic reaction due to other serum, sub...
          • T80.59XS Anaphylactic reaction due to other serum, seq...
      • T80.6 Other serum reactions
        • T80.61 Other serum reaction due to administration of...
          • T80.61XA Other serum reaction due to administration of...
          • T80.61XD Other serum reaction due to administration of...
          • T80.61XS Other serum reaction due to administration of...
        • T80.62 Other serum reaction due to vaccination
          • T80.62XA Other serum reaction due to vaccination, init...
          • T80.62XD Other serum reaction due to vaccination, subs...
          • T80.62XS Other serum reaction due to vaccination, sequ...
        • T80.69 Other serum reaction due to other serum
          • T80.69XA Other serum reaction due to other serum, init...
          • T80.69XD Other serum reaction due to other serum, subs...
          • T80.69XS Other serum reaction due to other serum, sequ...
      • T80.8 Other complications following infusion, trans...
        • T80.81 Extravasation of vesicant agent
          • T80.810 Extravasation of vesicant antineoplastic chem...
            • T80.810A Extravasation of vesicant antineoplastic chem...
            • T80.810D Extravasation of vesicant antineoplastic chem...
            • T80.810S Extravasation of vesicant antineoplastic chem...
          • T80.818 Extravasation of other vesicant agent
            • T80.818A Extravasation of other vesicant agent, initia...
            • T80.818D Extravasation of other vesicant agent, subseq...
            • T80.818S Extravasation of other vesicant agent, sequel...
        • T80.89 Other complications following infusion, trans...
          • T80.89XA Other complications following infusion, trans...
          • T80.89XD Other complications following infusion, trans...
          • T80.89XS Other complications following infusion, trans...
      • T80.9 Unspecified complication following infusion, ...
        • T80.90 Unspecified complication following infusion a...
          • T80.90XA Unspecified complication following infusion a...
          • T80.90XD Unspecified complication following infusion a...
          • T80.90XS Unspecified complication following infusion a...
        • T80.91 Hemolytic transfusion reaction, unspecified i...
          • T80.910 Acute hemolytic transfusion reaction, unspeci...
            • T80.910A Acute hemolytic transfusion reaction, unspeci...
            • T80.910D Acute hemolytic transfusion reaction, unspeci...
            • T80.910S Acute hemolytic transfusion reaction, unspeci...
          • T80.911 Delayed hemolytic transfusion reaction, unspe...
            • T80.911A Delayed hemolytic transfusion reaction, unspe...
            • T80.911D Delayed hemolytic transfusion reaction, unspe...
            • T80.911S Delayed hemolytic transfusion reaction, unspe...
          • T80.919 Hemolytic transfusion reaction, unspecified i...
            • T80.919A Hemolytic transfusion reaction, unspecified i...
            • T80.919D Hemolytic transfusion reaction, unspecified i...
            • T80.919S Hemolytic transfusion reaction, unspecified i...
        • T80.92 Unspecified transfusion reaction
          • T80.92XA Unspecified transfusion reaction, initial enc...
          • T80.92XD Unspecified transfusion reaction, subsequent ...
          • T80.92XS …… sequela
    T80.-
    )
The following code(s) above T45.8 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to T45.8:
  • S00-T88
    2020 ICD-10-CM Range S00-T88

    Injury, poisoning and certain other consequences of external causes

    Note
    • Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. Codes within the T section that include the external cause do not require an additional external cause code
    Type 1 Excludes
    Use Additional
    • code to identify any retained foreign body, if applicable (Z18.-)
    Injury, poisoning and certain other consequences of external causes
  • T36-T50
    2020 ICD-10-CM Range T36-T50

    Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances

    Code First
    • , for adverse effects, the nature of the adverse effect, such as:
    • adverse effect NOS (T88.7)
    • aspirin gastritis (K29.-)
    • blood disorders (D56-D76)
    • contact dermatitis (L23-L25)
    • dermatitis due to substances taken internally (L27.-)
    • nephropathy (N14.0-N14.2)
    Includes
    • adverse effect of correct substance properly administered
    • poisoning by overdose of substance
    • poisoning by wrong substance given or taken in error
    • underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed
    Note
    • The drug giving rise to the adverse effect should be identified by use of codes from categories T36-T50 with fifth or sixth character 5.
    Type 1 Excludes
    • toxic reaction to local anesthesia in pregnancy (O29.3-)
    Type 2 Excludes
    • abuse and dependence of psychoactive substances (F10-F19)
    • abuse of non-dependence-producing substances (F55.-)
    • drug reaction and poisoning affecting newborn (P00-P96)
    • pathological drug intoxication (inebriation) (F10-F19)
    Use Additional
    • code(s) to specify:
    • manifestations of poisoning
    • underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
    • underdosing of medication regimen (Z91.12-, Z91.13-)
    Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
ICD-10-CM Codes Adjacent To T45.8
T45.7X4D …… subsequent encounter
T45.7X4S …… sequela
T45.7X5 Adverse effect of anticoagulant antagonists, vitamin K and other coagulants
T45.7X5A …… initial encounter
T45.7X5D …… subsequent encounter
T45.7X5S …… sequela
T45.7X6 Underdosing of anticoagulant antagonist, vitamin K and other coagulants
T45.7X6A …… initial encounter
T45.7X6D …… subsequent encounter
T45.7X6S …… sequela
T45.8 Poisoning by, adverse effect of and underdosing of other primarily systemic and hematological agents
T45.8X Poisoning by, adverse effect of and underdosing of other primarily systemic and hematological agents
T45.8X1 Poisoning by other primarily systemic and hematological agents, accidental (unintentional)
T45.8X1A …… initial encounter
T45.8X1D …… subsequent encounter
T45.8X1S …… sequela
T45.8X2 Poisoning by other primarily systemic and hematological agents, intentional self-harm
T45.8X2A …… initial encounter
T45.8X2D …… subsequent encounter
T45.8X2S …… sequela
T45.8X3 Poisoning by other primarily systemic and hematological agents, assault

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.