2020 ICD-10-CM Diagnosis Code T80.5

Anaphylactic reaction due to serum

    2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
  • T80.5 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2020 edition of ICD-10-CM T80.5 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of T80.5 - other international versions of ICD-10 T80.5 may differ.
Applicable To
  • Allergic shock due to serum
  • Anaphylactic shock due to serum
  • Anaphylactoid reaction due to serum
  • Anaphylaxis due to serum
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as T80.5. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • ABO incompatibility reaction due to transfusion of blood or blood products (
    ICD-10-CM Diagnosis Code T80.3

    ABO incompatibility reaction due to transfusion of blood or blood products

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • minor blood group antigens reactions (Duffy) (E) (K) (Kell) (Kidd) (Lewis) (M) (N) (P) (S) (T80.A-)
    T80.3-
    )
  • allergic reaction or shock NOS (
    ICD-10-CM Diagnosis Code T78.2

    Anaphylactic shock, unspecified

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Applicable To
    • Allergic shock
    • Anaphylactic reaction
    • Anaphylaxis
    Type 1 Excludes
    • anaphylactic reaction or shock due to adverse effect of correct medicinal substance properly administered (T88.6)
    • anaphylactic reaction or shock due to adverse food reaction (T78.0-)
    • anaphylactic reaction or shock due to serum (T80.5-)
    T78.2
    )
  • anaphylactic reaction or shock NOS (
    ICD-10-CM Diagnosis Code T78.2

    Anaphylactic shock, unspecified

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Applicable To
    • Allergic shock
    • Anaphylactic reaction
    • Anaphylaxis
    Type 1 Excludes
    • anaphylactic reaction or shock due to adverse effect of correct medicinal substance properly administered (T88.6)
    • anaphylactic reaction or shock due to adverse food reaction (T78.0-)
    • anaphylactic reaction or shock due to serum (T80.5-)
    T78.2
    )
  • anaphylactic reaction or shock due to adverse effect of correct medicinal substance properly administered (
    ICD-10-CM Diagnosis Code T88.6

    Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Applicable To
    • Anaphylactic shock due to adverse effect of correct drug or medicament properly administered
    • Anaphylactoid reaction NOS
    Type 1 Excludes
    • anaphylactic reaction due to serum (T80.5-)
    • anaphylactic shock or reaction due to adverse food reaction (T78.0-)
    Use Additional
    • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
    T88.6
    )
  • other serum reaction (
    ICD-10-CM Diagnosis Code T80.6

    Other serum reactions

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Applicable To
    • Intoxication by serum
    • Protein sickness
    • Serum rash
    • Serum sickness
    • Serum urticaria
    Type 2 Excludes
    T80.6-
    )
The following code(s) above T80.5 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to T80.5:
  • S00-T88
    2020 ICD-10-CM Range S00-T88

    Injury, poisoning and certain other consequences of external causes

    Note
    • Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. Codes within the T section that include the external cause do not require an additional external cause code
    Type 1 Excludes
    Use Additional
    • code to identify any retained foreign body, if applicable (Z18.-)
    Injury, poisoning and certain other consequences of external causes
  • T80-T88
    2020 ICD-10-CM Range T80-T88

    Complications of surgical and medical care, not elsewhere classified

    Type 2 Excludes
    • any encounters with medical care for postprocedural conditions in which no complications are present, such as:
    • artificial opening status (Z93.-)
    • closure of external stoma (Z43.-)
    • fitting and adjustment of external prosthetic device (Z44.-)
    • burns and corrosions from local applications and irradiation (T20-T32)
    • complications of surgical procedures during pregnancy, childbirth and the puerperium (O00-O9A)
    • mechanical complication of respirator [ventilator] (J95.850)
    • poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4 or 6)
    • postprocedural fever (R50.82)
    • specified complications classified elsewhere, such as:
    • cerebrospinal fluid leak from spinal puncture (G97.0)
    • colostomy malfunction (K94.0-)
    • disorders of fluid and electrolyte imbalance (E86-E87)
    • functional disturbances following cardiac surgery (I97.0-I97.1)
    • intraoperative and postprocedural complications of specified body systems (D78.-, E36.-, E89.-, G97.3-, G97.4, H59.3-, H59.-, H95.2-, H95.3, I97.4-, I97.5, J95.6-, J95.7, K91.6-, L76.-, M96.-, N99.-)
    • ostomy complications (J95.0-, K94.-, N99.5-)
    • postgastric surgery syndromes (K91.1)
    • postlaminectomy syndrome NEC (M96.1)
    • postmastectomy lymphedema syndrome (I97.2)
    • postsurgical blind-loop syndrome (K91.2)
    • ventilator associated pneumonia (J95.851)
    Use Additional
    • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
    Complications of surgical and medical care, not elsewhere classified
  • T80
    ICD-10-CM Diagnosis Code T80

    Complications following infusion, transfusion and therapeutic injection

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Includes
    • complications following perfusion
    Type 2 Excludes
    • bone marrow transplant rejection (T86.01)
    • febrile nonhemolytic transfusion reaction (R50.84)
    • fluid overload due to transfusion (E87.71)
    • posttransfusion purpura (D69.51)
    • transfusion associated circulatory overload (TACO) (E87.71)
    • transfusion (red blood cell) associated hemochromatosis (E83.111)
    • transfusion related acute lung injury (TRALI) (J95.84)
    Complications following infusion, transfusion and therapeutic injection
Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
Code annotations containing back-references to T80.5:
  • Type 1 Excludes: T88.6
    , T79.4
    , T78.2
    , T81.1
    , R57
    ICD-10-CM Diagnosis Code T88.6

    Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Applicable To
    • Anaphylactic shock due to adverse effect of correct drug or medicament properly administered
    • Anaphylactoid reaction NOS
    Type 1 Excludes
    • anaphylactic reaction due to serum (T80.5-)
    • anaphylactic shock or reaction due to adverse food reaction (T78.0-)
    Use Additional
    • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
    ICD-10-CM Diagnosis Code T79.4

    Traumatic shock

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Applicable To
    • Shock (immediate) (delayed) following injury
    Type 1 Excludes
    • anaphylactic shock due to adverse food reaction (T78.0-)
    • anaphylactic shock due to correct medicinal substance properly administered (T88.6)
    • anaphylactic shock due to serum (T80.5-)
    • anaphylactic shock NOS (T78.2)
    • anesthetic shock (T88.2)
    • electric shock (T75.4)
    • nontraumatic shock NEC (R57.-)
    • obstetric shock (O75.1)
    • postprocedural shock (T81.1-)
    • septic shock (R65.21)
    • shock complicating abortion or ectopic or molar pregnancy (O00-O07, O08.3)
    • shock due to lightning (T75.01)
    • shock NOS (R57.9)
    ICD-10-CM Diagnosis Code T78.2

    Anaphylactic shock, unspecified

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Applicable To
    • Allergic shock
    • Anaphylactic reaction
    • Anaphylaxis
    Type 1 Excludes
    • anaphylactic reaction or shock due to adverse effect of correct medicinal substance properly administered (T88.6)
    • anaphylactic reaction or shock due to adverse food reaction (T78.0-)
    • anaphylactic reaction or shock due to serum (T80.5-)
    ICD-10-CM Diagnosis Code T81.1

    Postprocedural shock

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Applicable To
    • Shock during or resulting from a procedure, not elsewhere classified
    Type 1 Excludes
    • anaphylactic shock NOS (T78.2)
    • anaphylactic shock due to correct substance properly administered (T88.6)
    • anaphylactic shock due to serum (T80.5-)
    • anesthetic shock (T88.2)
    • electric shock (T75.4)
    • obstetric shock (O75.1)
    • septic shock (R65.21)
    • shock following abortion or ectopic or molar pregnancy (O00-O07, O08.3)
    • traumatic shock (T79.4)
    ICD-10-CM Diagnosis Code R57

    Shock, not elsewhere classified

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • anaphylactic shock NOS (T78.2)
    • anaphylactic reaction or shock due to adverse food reaction (T78.0-)
    • anaphylactic shock due to adverse effect of correct drug or medicament properly administered (T88.6)
    • anaphylactic shock due to serum (T80.5-)
    • anesthetic shock (T88.3)
    • electric shock (T75.4)
    • obstetric shock (O75.1)
    • postprocedural shock (T81.1-)
    • psychic shock (F43.0)
    • shock complicating or following ectopic or molar pregnancy (O00-O07, O08.3)
    • shock due to lightning (T75.01)
    • traumatic shock (T79.4)
    • toxic shock syndrome (A48.3)
  • Type 2 Excludes: T88.1
    ICD-10-CM Diagnosis Code T88.1

    Other complications following immunization, not elsewhere classified

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Applicable To
    • Generalized vaccinia
    • Rash following immunization
    Type 1 Excludes
    • vaccinia not from vaccine (B08.011)
    Type 2 Excludes
    • anaphylactic shock due to serum (T80.5-)
    • other serum reactions (T80.6-)
    • postimmunization arthropathy (M02.2)
    • postimmunization encephalitis (G04.02)
    • postimmunization fever (R50.83)
ICD-10-CM Codes Adjacent To T80.5
T80.A11D …… subsequent encounter
T80.A11S …… sequela
T80.A19 Non-ABO incompatibility with hemolytic transfusion reaction, unspecified
T80.A19A …… initial encounter
T80.A19D …… subsequent encounter
T80.A19S …… sequela
T80.A9 Other non-ABO incompatibility reaction due to transfusion of blood or blood products
T80.A9XA …… initial encounter
T80.A9XD …… subsequent encounter
T80.A9XS …… sequela
T80.5 Anaphylactic reaction due to serum
T80.51 Anaphylactic reaction due to administration of blood and blood products
T80.51XA …… initial encounter
T80.51XD …… subsequent encounter
T80.51XS …… sequela
T80.52 Anaphylactic reaction due to vaccination
T80.52XA …… initial encounter
T80.52XD …… subsequent encounter
T80.52XS …… sequela
T80.59 Anaphylactic reaction due to other serum
T80.59XA …… initial encounter

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.