2020 ICD-10-CM Diagnosis Code T80.6

Other serum reactions

    2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
  • T80.6 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2020 edition of ICD-10-CM T80.6 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of T80.6 - other international versions of ICD-10 T80.6 may differ.
Applicable To
  • Intoxication by serum
  • Protein sickness
  • Serum rash
  • Serum sickness
  • Serum urticaria
Type 2 Excludes
Type 2 Excludes Help
A type 2 excludes note represents "not included here". A type 2 excludes note indicates that the condition excluded is not part of the condition it is excluded from but a patient may have both conditions at the same time. When a type 2 excludes note appears under a code it is acceptable to use both the code (T80.6) and the excluded code together.
  • serum hepatitis (
    ICD-10-CM Diagnosis Code B16

    Acute hepatitis B

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    B16
    -
    ICD-10-CM Diagnosis Code B19

    Unspecified viral hepatitis

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    B19
    )
The following code(s) above T80.6 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to T80.6:
  • S00-T88
    2020 ICD-10-CM Range S00-T88

    Injury, poisoning and certain other consequences of external causes

    Note
    • Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. Codes within the T section that include the external cause do not require an additional external cause code
    Type 1 Excludes
    Use Additional
    • code to identify any retained foreign body, if applicable (Z18.-)
    Injury, poisoning and certain other consequences of external causes
  • T80-T88
    2020 ICD-10-CM Range T80-T88

    Complications of surgical and medical care, not elsewhere classified

    Type 2 Excludes
    • any encounters with medical care for postprocedural conditions in which no complications are present, such as:
    • artificial opening status (Z93.-)
    • closure of external stoma (Z43.-)
    • fitting and adjustment of external prosthetic device (Z44.-)
    • burns and corrosions from local applications and irradiation (T20-T32)
    • complications of surgical procedures during pregnancy, childbirth and the puerperium (O00-O9A)
    • mechanical complication of respirator [ventilator] (J95.850)
    • poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4 or 6)
    • postprocedural fever (R50.82)
    • specified complications classified elsewhere, such as:
    • cerebrospinal fluid leak from spinal puncture (G97.0)
    • colostomy malfunction (K94.0-)
    • disorders of fluid and electrolyte imbalance (E86-E87)
    • functional disturbances following cardiac surgery (I97.0-I97.1)
    • intraoperative and postprocedural complications of specified body systems (D78.-, E36.-, E89.-, G97.3-, G97.4, H59.3-, H59.-, H95.2-, H95.3, I97.4-, I97.5, J95.6-, J95.7, K91.6-, L76.-, M96.-, N99.-)
    • ostomy complications (J95.0-, K94.-, N99.5-)
    • postgastric surgery syndromes (K91.1)
    • postlaminectomy syndrome NEC (M96.1)
    • postmastectomy lymphedema syndrome (I97.2)
    • postsurgical blind-loop syndrome (K91.2)
    • ventilator associated pneumonia (J95.851)
    Use Additional
    • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
    Complications of surgical and medical care, not elsewhere classified
  • T80
    ICD-10-CM Diagnosis Code T80

    Complications following infusion, transfusion and therapeutic injection

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Includes
    • complications following perfusion
    Type 2 Excludes
    • bone marrow transplant rejection (T86.01)
    • febrile nonhemolytic transfusion reaction (R50.84)
    • fluid overload due to transfusion (E87.71)
    • posttransfusion purpura (D69.51)
    • transfusion associated circulatory overload (TACO) (E87.71)
    • transfusion (red blood cell) associated hemochromatosis (E83.111)
    • transfusion related acute lung injury (TRALI) (J95.84)
    Complications following infusion, transfusion and therapeutic injection
Clinical Information
  • A disorder characterized by a delayed-type hypersensitivity reaction to foreign proteins derived from an animal serum. It occurs approximately six to twenty-one days following the administration of the foreign antigen. Symptoms include fever, arthralgias, myalgias, skin eruptions, lymphadenopathy, chest marked discomfort and dyspnea.
  • Delayed-type hypersensitivity reaction to foreign proteins derived from an animal serum. It occurs approximately six to twenty one days following the administration of the foreign antigen. Symptoms include fever, arthralgias, myalgias, skin eruptions, lymphadenopathy, chest pain, and dyspnea. Certain drugs (e.g., antibiotics, anticancer agents, and anti-inflammatory medications) and infectious disorders (e.g., hepatitis b) may also cause serum sickness-like reaction.
  • Immune complex disease caused by the administration of foreign serum or serum proteins and characterized by fever, lymphadenopathy, arthralgia, and urticaria. When they are complexed to protein carriers, some drugs can also cause serum sickness when they act as haptens inducing antibody responses.
  • Immune complex disease caused by the administration of foreign serum or serum proteins and characterized by fever, lymphadenopathy, arthralgia, and urticaria; when they are complexed to protein carriers, some drugs can also cause serum sickness when they act as haptens inducing antibody responses.
Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
Code annotations containing back-references to T80.6:
  • Code First: M36.4
    ICD-10-CM Diagnosis Code M36.4

    Arthropathy in hypersensitivity reactions classified elsewhere

      2016 2017 2018 2019 2020 Billable/Specific Code Manifestation Code
    Code First
    • underlying disease, such as:
    • Henoch (-Schönlein) purpura (D69.0)
    • serum sickness (T80.6-)
  • Type 1 Excludes: T78.3
    , T80.5
    , L50
    , L95
    ICD-10-CM Diagnosis Code T78.3

    Angioneurotic edema

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Applicable To
    • Allergic angioedema
    • Giant urticaria
    • Quincke's edema
    Type 1 Excludes
    ICD-10-CM Diagnosis Code T80.5

    Anaphylactic reaction due to serum

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Applicable To
    • Allergic shock due to serum
    • Anaphylactic shock due to serum
    • Anaphylactoid reaction due to serum
    • Anaphylaxis due to serum
    Type 1 Excludes
    • ABO incompatibility reaction due to transfusion of blood or blood products (T80.3-)
    • allergic reaction or shock NOS (T78.2)
    • anaphylactic reaction or shock NOS (T78.2)
    • anaphylactic reaction or shock due to adverse effect of correct medicinal substance properly administered (T88.6)
    • other serum reaction (T80.6-)
    ICD-10-CM Diagnosis Code L50

    Urticaria

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • allergic contact dermatitis (L23.-)
    • angioneurotic edema (T78.3)
    • giant urticaria (T78.3)
    • hereditary angio-edema (D84.1)
    • Quincke's edema (T78.3)
    • serum urticaria (T80.6-)
    • solar urticaria (L56.3)
    • urticaria neonatorum (P83.8)
    • urticaria papulosa (L28.2)
    • urticaria pigmentosa (D47.01)
    ICD-10-CM Diagnosis Code L95

    Vasculitis limited to skin, not elsewhere classified

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • angioma serpiginosum (L81.7)
    • Henoch(-Schönlein) purpura (D69.0)
    • hypersensitivity angiitis (M31.0)
    • lupus panniculitis (L93.2)
    • panniculitis NOS (M79.3)
    • panniculitis of neck and back (M54.0-)
    • polyarteritis nodosa (M30.0)
    • relapsing panniculitis (M35.6)
    • rheumatoid vasculitis (M05.2)
    • serum sickness (T80.6-)
    • urticaria (L50.-)
    • Wegener's granulomatosis (M31.3-)
  • Type 2 Excludes: T88.1
    ICD-10-CM Diagnosis Code T88.1

    Other complications following immunization, not elsewhere classified

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Applicable To
    • Generalized vaccinia
    • Rash following immunization
    Type 1 Excludes
    • vaccinia not from vaccine (B08.011)
    Type 2 Excludes
    • anaphylactic shock due to serum (T80.5-)
    • other serum reactions (T80.6-)
    • postimmunization arthropathy (M02.2)
    • postimmunization encephalitis (G04.02)
    • postimmunization fever (R50.83)
ICD-10-CM Codes Adjacent To T80.6
T80.51XD …… subsequent encounter
T80.51XS …… sequela
T80.52 Anaphylactic reaction due to vaccination
T80.52XA …… initial encounter
T80.52XD …… subsequent encounter
T80.52XS …… sequela
T80.59 Anaphylactic reaction due to other serum
T80.59XA …… initial encounter
T80.59XD …… subsequent encounter
T80.59XS …… sequela
T80.6 Other serum reactions
T80.61 Other serum reaction due to administration of blood and blood products
T80.61XA …… initial encounter
T80.61XD …… subsequent encounter
T80.61XS …… sequela
T80.62 Other serum reaction due to vaccination
T80.62XA …… initial encounter
T80.62XD …… subsequent encounter
T80.62XS …… sequela
T80.69 Other serum reaction due to other serum
T80.69XA …… initial encounter

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.