2022 ICD-10-CM Diagnosis Code T80.82

Complication of immune effector cellular therapy

    2022 - New Code Non-Billable/Non-Specific Code
  • T80.82 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • ICD-10-CM T80.82 is a new 2022 ICD-10-CM code that became effective on October 1, 2021.
  • This is the American ICD-10-CM version of T80.82 - other international versions of ICD-10 T80.82 may differ.
Applicable To
  • Complication of chimeric antigen receptor (CAR-T) cell therapy
  • Complication of IEC therapy
Use Additional
Use Additional Help
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
  • code to identify the specific complication, such as:
  • cytokine release syndrome (
    ICD-10-CM Diagnosis Code D89.83

    Cytokine release syndrome

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Code First
    • underlying cause, such as:
    • complications following infusion, transfusion and therapeutic injection (T80.89-)
    • complications of transplanted organs and tissue (T86.-)
    Use Additional
    • code to identify associated manifestations
    D89.83-
    )
  • immune effector cell-associated neurotoxicity syndrome (
    ICD-10-CM Diagnosis Code G92.0

    Immune effector cell-associated neurotoxicity syndrome

      2022 - New Code Non-Billable/Non-Specific Code
    Code First
    • underlying cause such as:
    • complications of immune effector cellular therapy (T80.82)
    Code Also
    • associated signs and symptoms, such as seizures and cerebral edema
    G92.0-
    )
Type 2 Excludes
Type 2 Excludes Help
A type 2 excludes note represents "not included here". A type 2 excludes note indicates that the condition excluded is not part of the condition it is excluded from but a patient may have both conditions at the same time. When a type 2 excludes note appears under a code it is acceptable to use both the code (T80.82) and the excluded code together.
  • complication of bone marrow transplant (
    ICD-10-CM Diagnosis Code T86.0

    Complications of bone marrow transplant

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    T86.0
    )
  • complication of stem cell transplant (
    ICD-10-CM Diagnosis Code T86.5

    Complications of stem cell transplant

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Complications from stem cells from peripheral blood
    • Complications from stem cells from umbilical cord
    T86.5
    )
The following code(s) above T80.82 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to T80.82:
  • S00-T88
    2022 ICD-10-CM Range S00-T88

    Injury, poisoning and certain other consequences of external causes

    Note
    • Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. Codes within the T section that include the external cause do not require an additional external cause code
    Type 1 Excludes
    Use Additional
    • code to identify any retained foreign body, if applicable (Z18.-)
    Injury, poisoning and certain other consequences of external causes
  • T80-T88
    2022 ICD-10-CM Range T80-T88

    Complications of surgical and medical care, not elsewhere classified

    Type 2 Excludes
    • any encounters with medical care for postprocedural conditions in which no complications are present, such as:
    • artificial opening status (Z93.-)
    • closure of external stoma (Z43.-)
    • fitting and adjustment of external prosthetic device (Z44.-)
    • burns and corrosions from local applications and irradiation (T20-T32)
    • complications of surgical procedures during pregnancy, childbirth and the puerperium (O00-O9A)
    • mechanical complication of respirator [ventilator] (J95.850)
    • poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4 or 6)
    • postprocedural fever (R50.82)
    • specified complications classified elsewhere, such as:
    • cerebrospinal fluid leak from spinal puncture (G97.0)
    • colostomy malfunction (K94.0-)
    • disorders of fluid and electrolyte imbalance (E86-E87)
    • functional disturbances following cardiac surgery (I97.0-I97.1)
    • intraoperative and postprocedural complications of specified body systems (D78.-, E36.-, E89.-, G97.3-, G97.4, H59.3-, H59.-, H95.2-, H95.3, I97.4-, I97.5, J95.6-, J95.7, K91.6-, L76.-, M96.-, N99.-)
    • ostomy complications (J95.0-, K94.-, N99.5-)
    • postgastric surgery syndromes (K91.1)
    • postlaminectomy syndrome NEC (M96.1)
    • postmastectomy lymphedema syndrome (I97.2)
    • postsurgical blind-loop syndrome (K91.2)
    • ventilator associated pneumonia (J95.851)
    Use Additional
    • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
    Complications of surgical and medical care, not elsewhere classified
  • T80
    ICD-10-CM Diagnosis Code T80

    Complications following infusion, transfusion and therapeutic injection

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Includes
    • complications following perfusion
    Type 2 Excludes
    • bone marrow transplant rejection (T86.01)
    • febrile nonhemolytic transfusion reaction (R50.84)
    • fluid overload due to transfusion (E87.71)
    • posttransfusion purpura (D69.51)
    • transfusion associated circulatory overload (TACO) (E87.71)
    • transfusion (red blood cell) associated hemochromatosis (E83.111)
    • transfusion related acute lung injury (TRALI) (J95.84)
    Complications following infusion, transfusion and therapeutic injection
Code History
  • 2022 (effective 10/1/2021): New code
Code annotations containing back-references to T80.82:
  • Code First: G92.0
    ICD-10-CM Diagnosis Code G92.0

    Immune effector cell-associated neurotoxicity syndrome

      2022 - New Code Non-Billable/Non-Specific Code
    Code First
    • underlying cause such as:
    • complications of immune effector cellular therapy (T80.82)
    Code Also
    • associated signs and symptoms, such as seizures and cerebral edema

Diagnosis Index entries containing back-references to T80.82:
  • Complication(s) (from) (of)
    • chimeric antigen receptor T80.82 (CAR-T)
    • IEC T80.82 (immune effector cellular)
    • immune effector cellular T80.82 (IEC)

ICD-10-CM Codes Adjacent To T80.82
T80.8 Other complications following infusion, transfusion and therapeutic injection
T80.81 Extravasation of vesicant agent
T80.810 Extravasation of vesicant antineoplastic chemotherapy
T80.810A …… initial encounter
T80.810D …… subsequent encounter
T80.810S …… sequela
T80.818 Extravasation of other vesicant agent
T80.818A …… initial encounter
T80.818D …… subsequent encounter
T80.818S …… sequela
T80.82 Complication of immune effector cellular therapy
T80.82XA …… initial encounter
T80.82XD …… subsequent encounter
T80.82XS …… sequela
T80.89 Other complications following infusion, transfusion and therapeutic injection
T80.89XA …… initial encounter
T80.89XD …… subsequent encounter
T80.89XS …… sequela
T80.9 Unspecified complication following infusion, transfusion and therapeutic injection
T80.90 Unspecified complication following infusion and therapeutic injection
T80.90XA …… initial encounter

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.