2021 ICD-10-CM Diagnosis Code Z16.20

Resistance to unspecified antibiotic

    2016 2017 2018 2019 2020 2021 Billable/Specific Code
  • Z16.20 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2021 edition of ICD-10-CM Z16.20 became effective on October 1, 2020.
  • This is the American ICD-10-CM version of Z16.20 - other international versions of ICD-10 Z16.20 may differ.
Applicable To
  • Resistance to antibiotics NOS
The following code(s) above Z16.20 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to Z16.20:
  • Z00-Z99
    2021 ICD-10-CM Range Z00-Z99

    Factors influencing health status and contact with health services

    • Z codes represent reasons for encounters. A corresponding procedure code must accompany a Z code if a procedure is performed. Categories Z00-Z99 are provided for occasions when circumstances other than a disease, injury or external cause classifiable to categories A00-Y89 are recorded as 'diagnoses' or 'problems'. This can arise in two main ways:
    • (a) When a person who may or may not be sick encounters the health services for some specific purpose, such as to receive limited care or service for a current condition, to donate an organ or tissue, to receive prophylactic vaccination (immunization), or to discuss a problem which is in itself not a disease or injury.
    • (b) When some circumstance or problem is present which influences the person's health status but is not in itself a current illness or injury.
    Factors influencing health status and contact with health services
  • Z16
    ICD-10-CM Diagnosis Code Z16

    Resistance to antimicrobial drugs

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Code First
    • the infection
    • The codes in this category are provided for use as additional codes to identify the resistance and non-responsiveness of a condition to antimicrobial drugs.
    Type 1 Excludes
    • Methicillin resistant Staphylococcus aureus infection (A49.02)
    • Methicillin resistant Staphylococcus aureus pneumonia (J15.212)
    • Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02)
    Resistance to antimicrobial drugs
Clinical Information
  • The mechanisms, functions, activities, or processes exhibited by microorganisms, especially bacteria, to resist or to become tolerant to antibiotics.
ICD-10-CM Z16.20 is grouped within Diagnostic Related Group(s) (MS-DRG v38.0):
  • 867 Other infectious and parasitic diseases diagnoses with mcc
  • 868 Other infectious and parasitic diseases diagnoses with cc
  • 869 Other infectious and parasitic diseases diagnoses without cc/mcc

Convert Z16.20 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change

Diagnosis Index entries containing back-references to Z16.20:

ICD-10-CM Codes Adjacent To Z16.20
Z15.8 Genetic susceptibility to other disease
Z15.81 Genetic susceptibility to multiple endocrine neoplasia [MEN]
Z15.89 Genetic susceptibility to other disease
Z16 Resistance to antimicrobial drugs
Z16.1 Resistance to beta lactam antibiotics
Z16.10 Resistance to unspecified beta lactam antibiotics
Z16.11 Resistance to penicillins
Z16.12 Extended spectrum beta lactamase (ESBL) resistance
Z16.19 Resistance to other specified beta lactam antibiotics
Z16.2 Resistance to other antibiotics
Z16.20 Resistance to unspecified antibiotic
Z16.21 Resistance to vancomycin
Z16.22 Resistance to vancomycin related antibiotics
Z16.23 Resistance to quinolones and fluoroquinolones
Z16.24 Resistance to multiple antibiotics
Z16.29 Resistance to other single specified antibiotic
Z16.3 Resistance to other antimicrobial drugs
Z16.30 Resistance to unspecified antimicrobial drugs
Z16.31 Resistance to antiparasitic drug(s)
Z16.32 Resistance to antifungal drug(s)
Z16.33 Resistance to antiviral drug(s)

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.