2022 ICD-10-CM Diagnosis Code Z16.30

Resistance to unspecified antimicrobial drugs

    2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  • Z16.30 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2022 edition of ICD-10-CM Z16.30 became effective on October 1, 2021.
  • This is the American ICD-10-CM version of Z16.30 - other international versions of ICD-10 Z16.30 may differ.
Applicable To
  • Drug resistance NOS
The following code(s) above Z16.30 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to Z16.30:
  • Z00-Z99
    2022 ICD-10-CM Range Z00-Z99

    Factors influencing health status and contact with health services

    • Z codes represent reasons for encounters. A corresponding procedure code must accompany a Z code if a procedure is performed. Categories Z00-Z99 are provided for occasions when circumstances other than a disease, injury or external cause classifiable to categories A00-Y89 are recorded as 'diagnoses' or 'problems'. This can arise in two main ways:
    • (a) When a person who may or may not be sick encounters the health services for some specific purpose, such as to receive limited care or service for a current condition, to donate an organ or tissue, to receive prophylactic vaccination (immunization), or to discuss a problem which is in itself not a disease or injury.
    • (b) When some circumstance or problem is present which influences the person's health status but is not in itself a current illness or injury.
    Factors influencing health status and contact with health services
  • Z16
    ICD-10-CM Diagnosis Code Z16

    Resistance to antimicrobial drugs

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Code First
    • the infection
    • The codes in this category are provided for use as additional codes to identify the resistance and non-responsiveness of a condition to antimicrobial drugs.
    Type 1 Excludes
    • Methicillin resistant Staphylococcus aureus infection (A49.02)
    • Methicillin resistant Staphylococcus aureus pneumonia (J15.212)
    • Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02)
    Resistance to antimicrobial drugs
  • Z16.3
    ICD-10-CM Diagnosis Code Z16.3

    Resistance to other antimicrobial drugs

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Type 1 Excludes
    Resistance to other antimicrobial drugs
Approximate Synonyms
  • Infection due to multiple drug resistant microorganisms
  • Infection due to resistant organism
  • Infection with microorganisms resistant to drugs
Clinical Information
  • Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from drug tolerance which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
  • Mechanisms, functions, activities, or processes exhibited by tumors or pathogens to withstand previously toxic drugs.
  • Obsolete (was not defined before being made obsolete). [goc:go_curators]
  • Tendency of biological systems (organisms, cells, or cell-free systems) to fail to respond as expected to drug treatment or exposure; may be due to specific enzymes, transporters, or receptors which block drug action.
  • The failure of cancer cells, viruses, or bacteria to respond to a drug used to kill or weaken them. The cells, viruses, or bacteria may be resistant to the drug at the beginning of treatment, or may become resistant after being exposed to the drug.
ICD-10-CM Z16.30 is grouped within Diagnostic Related Group(s) (MS-DRG v39.0):
  • 867 Other infectious and parasitic diseases diagnoses with mcc
  • 868 Other infectious and parasitic diseases diagnoses with cc
  • 869 Other infectious and parasitic diseases diagnoses without cc/mcc

Convert Z16.30 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change

Diagnosis Index entries containing back-references to Z16.30:

ICD-10-CM Codes Adjacent To Z16.30
Z16.12 Extended spectrum beta lactamase (ESBL) resistance
Z16.19 Resistance to other specified beta lactam antibiotics
Z16.2 Resistance to other antibiotics
Z16.20 Resistance to unspecified antibiotic
Z16.21 Resistance to vancomycin
Z16.22 Resistance to vancomycin related antibiotics
Z16.23 Resistance to quinolones and fluoroquinolones
Z16.24 Resistance to multiple antibiotics
Z16.29 Resistance to other single specified antibiotic
Z16.3 Resistance to other antimicrobial drugs
Z16.30 Resistance to unspecified antimicrobial drugs
Z16.31 Resistance to antiparasitic drug(s)
Z16.32 Resistance to antifungal drug(s)
Z16.33 Resistance to antiviral drug(s)
Z16.34 Resistance to antimycobacterial drug(s)
Z16.341 Resistance to single antimycobacterial drug
Z16.342 Resistance to multiple antimycobacterial drugs
Z16.35 Resistance to multiple antimicrobial drugs
Z16.39 Resistance to other specified antimicrobial drug
Z17 Estrogen receptor status
Z17.0 Estrogen receptor positive status [ER+]

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.