2020 ICD-10-CM Diagnosis Code Z21

Asymptomatic human immunodeficiency virus [HIV] infection status

    2016 2017 2018 2019 2020 Billable/Specific Code Questionable As Admission Dx
  • Z21 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • Short description: Asymptomatic human immunodeficiency virus infection status
  • The 2020 edition of ICD-10-CM Z21 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of Z21 - other international versions of ICD-10 Z21 may differ.
ICD-10-CM Coding Rules
  • Z21 is not usually sufficient justification for admission to an acute care hospital when used a principal diagnosis.
Applicable To
  • HIV positive NOS
Code First
Code First Help
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
  • Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium, if applicable (
    ICD-10-CM Diagnosis Code O98.7

    Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Use Additional
    • code to identify the type of HIV disease:
    • Acquired immune deficiency syndrome (AIDS) (B20)
    • Asymptomatic HIV status (Z21)
    • HIV positive NOS (Z21)
    • Symptomatic HIV disease (B20)
    O98.7-
    )
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as Z21. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • acquired immunodeficiency syndrome (
    ICD-10-CM Diagnosis Code B20

    Human immunodeficiency virus [HIV] disease

      2016 2017 2018 2019 2020 Billable/Specific Code
    Code First
    • Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium, if applicable (O98.7-)
    Includes
    • acquired immune deficiency syndrome [AIDS]
    • AIDS-related complex [ARC]
    • HIV infection, symptomatic
    Type 1 Excludes
    • asymptomatic human immunodeficiency virus [HIV] infection status (Z21)
    • exposure to HIV virus (Z20.6)
    • inconclusive serologic evidence of HIV (R75)
    Use Additional
    • code(s) to identify all manifestations of HIV infection
    B20
    )
  • contact with human immunodeficiency virus [HIV] (
    ICD-10-CM Diagnosis Code Z20.6

    Contact with and (suspected) exposure to human immunodeficiency virus [HIV]

      2016 2017 2018 2019 2020 Billable/Specific Code
    Type 1 Excludes
    • asymptomatic human immunodeficiency virus [HIV]
    • HIV infection status (Z21)
    Z20.6
    )
  • exposure to human immunodeficiency virus [HIV] (
    ICD-10-CM Diagnosis Code Z20.6

    Contact with and (suspected) exposure to human immunodeficiency virus [HIV]

      2016 2017 2018 2019 2020 Billable/Specific Code
    Type 1 Excludes
    • asymptomatic human immunodeficiency virus [HIV]
    • HIV infection status (Z21)
    Z20.6
    )
  • human immunodeficiency virus [HIV] disease (
    ICD-10-CM Diagnosis Code B20

    Human immunodeficiency virus [HIV] disease

      2016 2017 2018 2019 2020 Billable/Specific Code
    Code First
    • Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium, if applicable (O98.7-)
    Includes
    • acquired immune deficiency syndrome [AIDS]
    • AIDS-related complex [ARC]
    • HIV infection, symptomatic
    Type 1 Excludes
    • asymptomatic human immunodeficiency virus [HIV] infection status (Z21)
    • exposure to HIV virus (Z20.6)
    • inconclusive serologic evidence of HIV (R75)
    Use Additional
    • code(s) to identify all manifestations of HIV infection
    B20
    )
  • inconclusive laboratory evidence of human immunodeficiency virus [HIV] (
    ICD-10-CM Diagnosis Code R75

    Inconclusive laboratory evidence of human immunodeficiency virus [HIV]

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Nonconclusive HIV-test finding in infants
    Type 1 Excludes
    • asymptomatic human immunodeficiency virus [HIV] infection status (Z21)
    • human immunodeficiency virus [HIV] disease (B20)
    R75
    )
The following code(s) above Z21 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to Z21:
  • Z00-Z99
    2020 ICD-10-CM Range Z00-Z99

    Factors influencing health status and contact with health services

    Note
    • Z codes represent reasons for encounters. A corresponding procedure code must accompany a Z code if a procedure is performed. Categories Z00-Z99 are provided for occasions when circumstances other than a disease, injury or external cause classifiable to categories A00-Y89 are recorded as 'diagnoses' or 'problems'. This can arise in two main ways:
    • (a) When a person who may or may not be sick encounters the health services for some specific purpose, such as to receive limited care or service for a current condition, to donate an organ or tissue, to receive prophylactic vaccination (immunization), or to discuss a problem which is in itself not a disease or injury.
    • (b) When some circumstance or problem is present which influences the person's health status but is not in itself a current illness or injury.
    Factors influencing health status and contact with health services
Approximate Synonyms
  • Acute hiv infection
  • Aids virus infection associated with pregnancy
  • Asymptomatic hiv infection
  • Asymptomatic human immunodeficiency virus a1 infection
  • Asymptomatic human immunodeficiency virus a2 infection
  • Asymptomatic human immunodeficiency virus infection
  • Hiv in childbirth
  • Hiv in pregnancy
  • Hiv infection with acute retroviral syndrome
  • Hiv positive
  • Human immunodeficiency virus infection postpartum
  • Postpartum (after childbirth) hiv
Clinical Information
  • Development of neutralizing antibodies in individuals who have been exposed to the human immunodeficiency virus (hiv/htlv-iii/lav).
  • Infected with the human immunodeficiency virus (hiv), the cause of acquired immunodeficiency syndrome (aids).
ICD-10-CM Z21 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0):
  • 865 Viral illness with mcc
  • 866 Viral illness without mcc

Convert Z21 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
Code annotations containing back-references to Z21:
  • Type 1 Excludes: B20
    , Z20.6
    , R75
    ICD-10-CM Diagnosis Code B20

    Human immunodeficiency virus [HIV] disease

      2016 2017 2018 2019 2020 Billable/Specific Code
    Code First
    • Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium, if applicable (O98.7-)
    Includes
    • acquired immune deficiency syndrome [AIDS]
    • AIDS-related complex [ARC]
    • HIV infection, symptomatic
    Type 1 Excludes
    • asymptomatic human immunodeficiency virus [HIV] infection status (Z21)
    • exposure to HIV virus (Z20.6)
    • inconclusive serologic evidence of HIV (R75)
    Use Additional
    • code(s) to identify all manifestations of HIV infection
    ICD-10-CM Diagnosis Code Z20.6

    Contact with and (suspected) exposure to human immunodeficiency virus [HIV]

      2016 2017 2018 2019 2020 Billable/Specific Code
    Type 1 Excludes
    • asymptomatic human immunodeficiency virus [HIV]
    • HIV infection status (Z21)
    ICD-10-CM Diagnosis Code R75

    Inconclusive laboratory evidence of human immunodeficiency virus [HIV]

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Nonconclusive HIV-test finding in infants
    Type 1 Excludes
    • asymptomatic human immunodeficiency virus [HIV] infection status (Z21)
    • human immunodeficiency virus [HIV] disease (B20)
  • Type 2 Excludes: Z78
    ICD-10-CM Diagnosis Code Z78

    Other specified health status

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 2 Excludes
    • asymptomatic human immunodeficiency virus [HIV] infection status (Z21)
    • postprocedural status (Z93-Z99)
    • sex reassignment status (Z87.890)
  • Use Additional: O98.7
    , O98.7
    ICD-10-CM Diagnosis Code O98.7

    Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Use Additional
    • code to identify the type of HIV disease:
    • Acquired immune deficiency syndrome (AIDS) (B20)
    • Asymptomatic HIV status (Z21)
    • HIV positive NOS (Z21)
    • Symptomatic HIV disease (B20)
    ICD-10-CM Diagnosis Code O98.7

    Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Use Additional
    • code to identify the type of HIV disease:
    • Acquired immune deficiency syndrome (AIDS) (B20)
    • Asymptomatic HIV status (Z21)
    • HIV positive NOS (Z21)
    • Symptomatic HIV disease (B20)

Diagnosis Index entries containing back-references to Z21:
  • HIV B20
    - see also Human, immunodeficiency virus
    ICD-10-CM Diagnosis Code B20

    Human immunodeficiency virus [HIV] disease

      2016 2017 2018 2019 2020 Billable/Specific Code
    Code First
    • Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium, if applicable (O98.7-)
    Includes
    • acquired immune deficiency syndrome [AIDS]
    • AIDS-related complex [ARC]
    • HIV infection, symptomatic
    Type 1 Excludes
    • asymptomatic human immunodeficiency virus [HIV] infection status (Z21)
    • exposure to HIV virus (Z20.6)
    • inconclusive serologic evidence of HIV (R75)
    Use Additional
    • code(s) to identify all manifestations of HIV infection
    • positive, seropositive Z21
  • Human
    • immunodeficiency virus (HIV) disease (infection) B20
      ICD-10-CM Diagnosis Code B20

      Human immunodeficiency virus [HIV] disease

        2016 2017 2018 2019 2020 Billable/Specific Code
      Code First
      • Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium, if applicable (O98.7-)
      Includes
      • acquired immune deficiency syndrome [AIDS]
      • AIDS-related complex [ARC]
      • HIV infection, symptomatic
      Type 1 Excludes
      • asymptomatic human immunodeficiency virus [HIV] infection status (Z21)
      • exposure to HIV virus (Z20.6)
      • inconclusive serologic evidence of HIV (R75)
      Use Additional
      • code(s) to identify all manifestations of HIV infection
      • asymptomatic status Z21
  • Status (post) - see also Presence (of)
    • human immunodeficiency virus Z21 (HIV)
  • Syndrome - see also Disease
    • retroviral seroconversion Z21 (acute)
    • seroconversion, retroviral Z21 (acute)
  • Test, tests, testing (for)
    • HIV (human immunodeficiency virus)
      • positive Z21
      • seropositive Z21

ICD-10-CM Codes Adjacent To Z21
Z20.81 Contact with and (suspected) exposure to other bacterial communicable diseases
Z20.810 Contact with and (suspected) exposure to anthrax
Z20.811 Contact with and (suspected) exposure to meningococcus
Z20.818 Contact with and (suspected) exposure to other bacterial communicable diseases
Z20.82 Contact with and (suspected) exposure to other viral communicable diseases
Z20.820 Contact with and (suspected) exposure to varicella
Z20.821 Contact with and (suspected) exposure to Zika virus
Z20.828 Contact with and (suspected) exposure to other viral communicable diseases
Z20.89 Contact with and (suspected) exposure to other communicable diseases
Z20.9 Contact with and (suspected) exposure to unspecified communicable disease
Z21 Asymptomatic human immunodeficiency virus [HIV] infection status
Z22 Carrier of infectious disease
Z22.0 Carrier of typhoid
Z22.1 Carrier of other intestinal infectious diseases
Z22.2 Carrier of diphtheria
Z22.3 Carrier of other specified bacterial diseases
Z22.31 Carrier of bacterial disease due to meningococci
Z22.32 Carrier of bacterial disease due to staphylococci
Z22.321 Carrier or suspected carrier of Methicillin susceptible Staphylococcus aureus
Z22.322 Carrier or suspected carrier of Methicillin resistant Staphylococcus aureus
Z22.33 Carrier of bacterial disease due to streptococci

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.