ICD-10-CM Codes
Z00-Z99
Z20-Z29
Z21-
2023 ICD-10-CM Diagnosis Code Z21

2023 ICD-10-CM Diagnosis Code Z21

Asymptomatic human immunodeficiency virus [HIV] infection status

2016

2017

2018

2019

2020

2021

2022

2023

Billable/Specific Code

Questionable As Admission Dx

Z21 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
Short description: Asymptomatic human immunodeficiency virus infection status
The 2023 edition of ICD-10-CM Z21 became effective on October 1, 2022.
This is the American ICD-10-CM version of Z21 - other international versions of ICD-10 Z21 may differ.

ICD-10-CM Coding Rules

Z21 is not usually sufficient justification for admission to an acute care hospital when used a principal diagnosis.

Applicable To

HIV positive NOS

Code First

Code First Help

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.

Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium, if applicable (
ICD-10-CM Diagnosis Code O98.7
Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium
Use Additional
- code to identify the type of HIV disease:
- Acquired immune deficiency syndrome (AIDS) (B20)
- Asymptomatic HIV status (Z21)
- HIV positive NOS (Z21)
- Symptomatic HIV disease (B20)
O98.7-
)

Type 1 Excludes

Type 1 Excludes Help

A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as Z21. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.

acquired immunodeficiency syndrome (
ICD-10-CM Diagnosis Code B20
Human immunodeficiency virus [HIV] disease
Code First
- Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium, if applicable (O98.7-)
Includes
- acquired immune deficiency syndrome [AIDS]
- AIDS-related complex [ARC]
- HIV infection, symptomatic
Type 1 Excludes
- asymptomatic human immunodeficiency virus [HIV] infection status (Z21)
- exposure to HIV virus (Z20.6)
- inconclusive serologic evidence of HIV (R75)
Use Additional
- code(s) to identify all manifestations of HIV infection
B20
)
contact with human immunodeficiency virus [HIV] (
ICD-10-CM Diagnosis Code Z20.6
Contact with and (suspected) exposure to human immunodeficiency virus [HIV]
Type 1 Excludes
- asymptomatic human immunodeficiency virus [HIV]
- HIV infection status (Z21)
Z20.6
)
exposure to human immunodeficiency virus [HIV] (
ICD-10-CM Diagnosis Code Z20.6
Contact with and (suspected) exposure to human immunodeficiency virus [HIV]
Type 1 Excludes
- asymptomatic human immunodeficiency virus [HIV]
- HIV infection status (Z21)
Z20.6
)
human immunodeficiency virus [HIV] disease (
ICD-10-CM Diagnosis Code B20
Human immunodeficiency virus [HIV] disease
Code First
- Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium, if applicable (O98.7-)
Includes
- acquired immune deficiency syndrome [AIDS]
- AIDS-related complex [ARC]
- HIV infection, symptomatic
Type 1 Excludes
- asymptomatic human immunodeficiency virus [HIV] infection status (Z21)
- exposure to HIV virus (Z20.6)
- inconclusive serologic evidence of HIV (R75)
Use Additional
- code(s) to identify all manifestations of HIV infection
B20
)
inconclusive laboratory evidence of human immunodeficiency virus [HIV] (
ICD-10-CM Diagnosis Code R75
Inconclusive laboratory evidence of human immunodeficiency virus [HIV]
Applicable To
- Nonconclusive HIV-test finding in infants
Type 1 Excludes
- asymptomatic human immunodeficiency virus [HIV] infection status (Z21)
- human immunodeficiency virus [HIV] disease (B20)
R75
)

The following code(s) above Z21 contain annotation back-references

Annotation Back-References

In this context, annotation back-references refer to codes that contain:

Applicable To annotations, or
Code Also annotations, or
Code First annotations, or
Excludes1 annotations, or
Excludes2 annotations, or
Includes annotations, or
Note annotations, or
Use Additional annotations

that may be applicable to Z21:

Z00-Z99
2023 ICD-10-CM Range Z00-Z99
Factors influencing health status and contact with health services
Note
- Z codes represent reasons for encounters. A corresponding procedure code must accompany a Z code if a procedure is performed. Categories Z00-Z99 are provided for occasions when circumstances other than a disease, injury or external cause classifiable to categories A00-Y89 are recorded as 'diagnoses' or 'problems'. This can arise in two main ways:
- (a) When a person who may or may not be sick encounters the health services for some specific purpose, such as to receive limited care or service for a current condition, to donate an organ or tissue, to receive prophylactic vaccination (immunization), or to discuss a problem which is in itself not a disease or injury.
- (b) When some circumstance or problem is present which influences the person's health status but is not in itself a current illness or injury.
Factors influencing health status and contact with health services

Approximate Synonyms

Acute hiv infection
Aids virus infection associated with pregnancy
Asymptomatic hiv infection
Asymptomatic human immunodeficiency virus a1 infection
Asymptomatic human immunodeficiency virus a2 infection
Asymptomatic human immunodeficiency virus infection
Hiv in childbirth
Hiv in pregnancy
Hiv infection with acute retroviral syndrome
Hiv positive
Human immunodeficiency virus infection postpartum
Postpartum (after childbirth) hiv

Clinical Information

Development of neutralizing antibodies in individuals who have been exposed to the human immunodeficiency virus (hiv/htlv-iii/lav).
Infected with the human immunodeficiency virus (hiv), the cause of acquired immunodeficiency syndrome (aids).

ICD-10-CM Z21 is grouped within Diagnostic Related Group(s) (MS-DRG v40.0):

865 Viral illness with mcc
866 Viral illness without mcc

Convert Z21 to ICD-9-CM

Code History

2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
2017 (effective 10/1/2016): No change
2018 (effective 10/1/2017): No change
2019 (effective 10/1/2018): No change
2020 (effective 10/1/2019): No change
2021 (effective 10/1/2020): No change
2022 (effective 10/1/2021): No change
2023 (effective 10/1/2022): No change

Code annotations containing back-references to Z21:

Type 1 Excludes: R75
, B20
, Z20.6

ICD-10-CM Diagnosis Code R75
Inconclusive laboratory evidence of human immunodeficiency virus [HIV]
Applicable To
- Nonconclusive HIV-test finding in infants
Type 1 Excludes
- asymptomatic human immunodeficiency virus [HIV] infection status (Z21)
- human immunodeficiency virus [HIV] disease (B20)
ICD-10-CM Diagnosis Code B20
Human immunodeficiency virus [HIV] disease
Code First
- Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium, if applicable (O98.7-)
Includes
- acquired immune deficiency syndrome [AIDS]
- AIDS-related complex [ARC]
- HIV infection, symptomatic
Type 1 Excludes
- asymptomatic human immunodeficiency virus [HIV] infection status (Z21)
- exposure to HIV virus (Z20.6)
- inconclusive serologic evidence of HIV (R75)
Use Additional
- code(s) to identify all manifestations of HIV infection
ICD-10-CM Diagnosis Code Z20.6
Contact with and (suspected) exposure to human immunodeficiency virus [HIV]
Type 1 Excludes
- asymptomatic human immunodeficiency virus [HIV]
- HIV infection status (Z21)
Type 2 Excludes: Z78

ICD-10-CM Diagnosis Code Z78
Other specified health status
Type 2 Excludes
- asymptomatic human immunodeficiency virus [HIV] infection status (Z21)
- postprocedural status (Z93-Z99)
- sex reassignment status (Z87.890)
Use Additional: O98.7
, O98.7

ICD-10-CM Diagnosis Code O98.7
Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium
Use Additional
- code to identify the type of HIV disease:
- Acquired immune deficiency syndrome (AIDS) (B20)
- Asymptomatic HIV status (Z21)
- HIV positive NOS (Z21)
- Symptomatic HIV disease (B20)
ICD-10-CM Diagnosis Code O98.7
Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium
Use Additional
- code to identify the type of HIV disease:
- Acquired immune deficiency syndrome (AIDS) (B20)
- Asymptomatic HIV status (Z21)
- HIV positive NOS (Z21)
- Symptomatic HIV disease (B20)

Diagnosis Index entries containing back-references to Z21:

HIV B20
- see also Human, immunodeficiency virus
ICD-10-CM Diagnosis Code B20
Human immunodeficiency virus [HIV] disease
Code First
Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium, if applicable (O98.7-)
Includes
acquired immune deficiency syndrome [AIDS]
AIDS-related complex [ARC]
HIV infection, symptomatic
Type 1 Excludes
asymptomatic human immunodeficiency virus [HIV] infection status (Z21)
exposure to HIV virus (Z20.6)
inconclusive serologic evidence of HIV (R75)
Use Additional
code(s) to identify all manifestations of HIV infection
- positive, seropositive Z21
Human
- immunodeficiency virus (HIV) disease (infection) B20
  ICD-10-CM Diagnosis Code B20
  Human immunodeficiency virus [HIV] disease
  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  Code First
  Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium, if applicable (O98.7-)
  Includes
  acquired immune deficiency syndrome [AIDS]
  AIDS-related complex [ARC]
  HIV infection, symptomatic
  Type 1 Excludes
  asymptomatic human immunodeficiency virus [HIV] infection status (Z21)
  exposure to HIV virus (Z20.6)
  inconclusive serologic evidence of HIV (R75)
  Use Additional
  code(s) to identify all manifestations of HIV infection
  - asymptomatic status Z21
Status (post) - see also Presence (of)
- human immunodeficiency virus Z21 (HIV)
Syndrome - see also Disease
- retroviral seroconversion Z21 (acute)
- seroconversion, retroviral Z21 (acute)
Test, tests, testing (for)
- HIV (human immunodeficiency virus)
  - positive Z21
  - seropositive Z21

ICD-10-CM Codes Adjacent To Z21

Z20.810 Contact with and (suspected) exposure to anthrax

Z20.811 Contact with and (suspected) exposure to meningococcus

Z20.818 Contact with and (suspected) exposure to other bacterial communicable diseases

Z20.82 Contact with and (suspected) exposure to other viral communicable diseases

Z20.820 Contact with and (suspected) exposure to varicella

Z20.821 Contact with and (suspected) exposure to Zika virus

Z20.822 Contact with and (suspected) exposure to COVID-19

Z20.828 Contact with and (suspected) exposure to other viral communicable diseases

Z20.89 Contact with and (suspected) exposure to other communicable diseases

Z20.9 Contact with and (suspected) exposure to unspecified communicable disease

Z21 Asymptomatic human immunodeficiency virus [HIV] infection status

Z22 Carrier of infectious disease

Z22.0 Carrier of typhoid

Z22.1 Carrier of other intestinal infectious diseases

Z22.2 Carrier of diphtheria

Z22.3 Carrier of other specified bacterial diseases

Z22.31 Carrier of bacterial disease due to meningococci

Z22.32 Carrier of bacterial disease due to staphylococci

Z22.321 Carrier or suspected carrier of Methicillin susceptible Staphylococcus aureus

Z22.322 Carrier or suspected carrier of Methicillin resistant Staphylococcus aureus

Z22.33 Carrier of bacterial disease due to streptococci

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

2023 ICD-10-CM Diagnosis Code Z21

Asymptomatic human immunodeficiency virus [HIV] infection status

Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium

Human immunodeficiency virus [HIV] disease

Contact with and (suspected) exposure to human immunodeficiency virus [HIV]

Contact with and (suspected) exposure to human immunodeficiency virus [HIV]

Human immunodeficiency virus [HIV] disease

Inconclusive laboratory evidence of human immunodeficiency virus [HIV]

Factors influencing health status and contact with health services

Inconclusive laboratory evidence of human immunodeficiency virus [HIV]

Human immunodeficiency virus [HIV] disease

Contact with and (suspected) exposure to human immunodeficiency virus [HIV]

Other specified health status

Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium

Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium

Human immunodeficiency virus [HIV] disease

Human immunodeficiency virus [HIV] disease